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Review Article | Open Access

Optogenetics to restore neural circuit function in Parkinson’s disease

Hyung Ho Yoon, Joongkee Min, Sang Ryong Jeon
Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea
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Abstract

Deep brain stimulation surgery has been performed in various movement disorders and psychiatric diseases. However, electrical stimulation may unexpectedly affect other types of adjacent neurons outside of the target area. Recently, optogenetics has provided the opportunity to modulate specific target neurons. Since this novel technique can individually control specific neurons in freely moving animals, it could be proposed to restore neural circuit function to related diseases, such as affective disorders, Huntington’s disease (HD), and Parkinson’s disease (PD). Herein, we discuss how optogenetics works as a treatment for Parkinson’s disease and other neural circuit dysfunctions.

Keywords

deep brain stimulationoptogeneticsneural circuitParkinson disease

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Journal of Neurorestoratology
Volume 6 Issue 1,
December 2018
Pages 88-92
DOI: 10.26599/JNR.2018.9040007
Cite this article:
Yoon HH, Min J, Jeon SR. Optogenetics to restore neural circuit function in Parkinson’s disease. Journal of Neurorestoratology, 2018, 6(1): 88-92. https://doi.org/10.26599/JNR.2018.9040007

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Received: 09 July 2018
Accepted: 11 September 2018
Published: 09 November 2018
© The author(s) 2018

© The authors 2018. This article is published with open access at http://jnr.tsinghuajournals.com
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