Impact of light roasted coffee enriched with chlorogenic acid on lipid and glycaemic indices in healthy obese adults. A randomized, double-blinded, placebo-controlled clinical trial

Coffee contains phytocomponents including caffeine, chlorogenic acid (CGA), and ferulic acid. This study was intended to explore the impact of light roasted coffee rich in CGA on anthropometric parameters, lipid, and glycaemic indices, along with various lipid metabolizing molecules in healthy obese subjects. Forty healthy obese subjects (n = 40) were recruited and divided into 2 groups as experimental (CGA-340 mg/day and caffeine-220 mg/day; n = 20) and placebo (CGA-12.4 mg/day and caffeine-220 mg/day; n = 20). Daily consumption of the experimental sample resulted in a significant decrease (p < 0.05) in body weight, body fat, BMI, waist circumference, total cholesterol, and low-density lipoprotein cholesterol. Various lipid metabolism-related signaling molecules like AMPK-α and PPAR-α were improved (p < 0.05) after 12 weeks of supplementation with experimental samples as compared to the placebo group. The adiponectin levels were increased (p < 0.05) in the experimental group, levels of leptin, LXR-α, and PPAR-γ were decreased (p < 0.05). No significant difference was observed in any glycaemic indices or hepatic/renal markers in either the experimental or placebo group. The present outcome depicts that consumption of coffee (experimental/test sample) rich in CGA and caffeine (holistically) for 12 weeks could positively alter various lipid metabolizing signaling molecules and thereby lower the body fat accumulation and the incidence of obesity.