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Review Article | Open Access

Integrating stem cell biology and organoid technology for skin regenerative therapies

Ke Zheng1,2,3( ), Qingyang Yang1,2,3, Yaojiong Wu1,2,3( )
Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China
State Key Laboratory of Chemical Oncogenomics, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China
Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen 518055, China
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Abstract

The skin is a complex organ that serves as a protective barrier and performs many other functions. Several populations of stem cells reside in the skin and are responsible for the structural and functional integrity of the organ and its behavior during skin aging. We aim to provide a comprehensive overview of current knowledge about skin stem cells and their role in aging and discuss how organoids are used in skin stem cell research, highlighting their advantages over traditional two-dimensional cell culture systems and their potential to enable us to gain more insight into aging skin and the development of regenerative therapies.

Keywords

stem cell therapyorganoidsskin agingregeneration therapy

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Health Engineering
Volume 1,
2025
Article number: 9460004
DOI: 10.26599/HE.2024.9460004

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Review Status: {{reviewData.commendedNum}} Commended , {{reviewData.revisionRequiredNum}} Revision Required , {{reviewData.notCommendedNum}} Not Commended Under Peer Review

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Cite this article:
Zheng K, Yang Q, Wu Y. Integrating stem cell biology and organoid technology for skin regenerative therapies. Health Engineering, 2025, 1: 9460004. https://doi.org/10.26599/HE.2024.9460004

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Received: 28 April 2024
Revised: 30 May 2024
Accepted: 14 June 2024
Published: 26 December 2025
© The Author(s) 2025. Published by Tsinghua University Press.

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the original author(s) and the source, a link to the license is provided, and any changes made are indicated. See (https://creativecommons.org/licenses/by/4.0/)