Mitochondria-targeted drug delivery systems for improving cancer therapy

Cancer poses a significant threat to human health because of its high morbidity and mortality. While traditional cancer therapies have demonstrated efficacy, they have limitations, such as systemic toxicity and acquired resistance. In recent years, targeting mitochondrial function has emerged as a promising approach to tumor therapy. In this review, we discuss the various methods used to specifically target mitochondria for tumor treatment and provide an overview of delivery systems designed for mitochondrial targeting in cancer therapy. By addressing the drawbacks of current treatment modalities and exploring the potential of mitochondrial targeting, this review contributes to the advancement of tumor therapy. The comprehensive analysis of the existing literature provides valuable insights and serves as a reference for researchers investigating targeted mitochondrial therapies for cancer. With a focus on novel delivery strategies, this work aims to bridge the gap between scientific exploration and clinical application, which will enhance our ability to effectively combat this pervasive health challenge.