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Open Access | Just Accepted

Dendrobium as Food Medicine Homology: Ornamental, Edible, and Neuroprotective Values

Nanqu Huang1,2,3, Wendi Huang2,3, Mei Wang2, Nanyu Kuang4,5, Shujun Li7, Yong Luo2,3,6, Wei Zhang7, Juan Huang7( )

1 National Drug Clinical Trial Institution, Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, Guizhou, China, 563000

2 Department of Neurology, Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, Guizhou, China, 563000

3 Department of Geriatrics, Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, Guizhou, China, 563000

4 Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, 200433

5 Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA, 21224

6 Key Laboratory of Brain Function and Brain Disease Prevention and Treatment of Guizhou Province, Zunyi, China

7 Key Laboratory of Basic Pharmacology and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Guizhou, China, 563000

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Abstract

Dendrobium, one of the largest genera in the Orchidaceae, represents a distinctive plant resource with ornamental, edible and medicinal value. Owing to its rich floral diversity and long history of dietary and medicinal use in East and Southeast Asia, Dendrobium has attracted sustained attention from horticulture, food science and pharmacological research. Ornamentally, this genus is characterized by diverse floral morphology, color variation, abundant germplasm resources, and well-established cultivation systems that support its widespread use. In terms of edible value, only certain species, especially Dendrobium officinale, have been formally incorporated into food use in China, with stems, flowers and leaves approved as food materials. These edible parts contain polysaccharides, flavonoids, alkaloids and phenolic compounds, providing a chemical basis for functional food development. Accumulating preclinical studies indicate that Dendrobium-derived constituents exert neuroprotective effects in experimental models of Alzheimer’s disease, Parkinson’s disease, aging, ischemic stroke and spinal cord injury. Reported mechanisms involve oxidative stress regulation, neuroinflammatory modulation, autophagy-lysosome pathways and gut-brain axis signaling. This review examines the ornamental, edible and neuroprotective value of Dendrobium from a food medicine homology, with emphasis on species-specific uses, edible-part composition, translational limits and future directions for rational development and application.

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Cite this article:
Huang N, Huang W, Wang M, et al. Dendrobium as Food Medicine Homology: Ornamental, Edible, and Neuroprotective Values. Food Science and Human Wellness, 2026, https://doi.org/10.26599/FSHW.2026.9251256

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Received: 19 January 2026
Revised: 04 March 2026
Accepted: 01 April 2026
Available online: 14 October 2026

© 2026 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).