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Open Access | Just Accepted

Food allergy: From mechanisms to management - a review of pathogenesis, novel diagnosis and dietary regulation strategies

Ping-Ping Donga,1Yan-Xiang Bia,1Xiao-Tong FanaJia-Bao Nia,bWen-Li TianaWen-Jun Penga ( )Xiao-Ming Fanga ( )

a State Key Laboratory of Resource Insects, Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, China

b College of Engineering, China Agricultural University, Beijing 100083, China

1 Contributed equally to this work.

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Abstract

As a global public health challenge, food allergy affects hundreds of millions of individuals worldwide. This review provides a recent advance in the field of food allergy, including developments in diagnostic techniques, allergy evaluation methods, and management strategies. In addition, the modulation of food allergies by natural active substances in foods is also emphasized. Combining bioinformatics diagnostics with regulation of dietary actives holds great promise for allergy prevention. Furthermore, evaluation methods that combine dynamic gastrointestinal digestion modeling with bioinformatics provides new ideas for revealing the structural stability of allergens. Finally, enhanced food allergy management has further improved the effectiveness of allergy prevention. This review provides a better understanding and novel insights into the prevention and control of food allergies, as well as explores the potential applications of natural bioactive substances in food allergy management strategies.

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Food Science and Human Wellness

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Cite this article:
Dong P-P, Bi Y-X, Fan X-T, et al. Food allergy: From mechanisms to management - a review of pathogenesis, novel diagnosis and dietary regulation strategies. Food Science and Human Wellness, 2026, https://doi.org/10.26599/FSHW.2026.9251136

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Received: 01 December 2025
Revised: 08 February 2026
Accepted: 20 March 2026
Available online: 29 May 2026

© 2026 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).