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Research Article | Open Access | Just Accepted

Integrating Functional Ingredients in Food into Ageing Research: Implications for Lifespan and Healthspan

Wanzi YaoaYuxin WangaZhengjie KongaKaifeng GuanaYu KangaYang FengaAiping Wangb,cJianguo Zhaod,eYifeng Zhanga( )Gaiping Zhanga,b,c,f,g( )

a Department of Food Safety and Health, School of Advanced Agricultural Sciences, Peking University, Beijing 100871, China

b Longhu Laboratory, Zhengzhou 450046, China

c School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China

d State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Science, Beijing 100101, China

e Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China

f International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agriculture University, Zhengzhou 450046, China

g Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China

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Abstract

As the global population ages at an unprecedented rate, identifying effective strategies to extend lifespan and mitigate age-related diseases has become imperative. Current research in nutrition for healthy ageing has increasingly focused on functional ingredients in food known to enhance longevity. Despite this, there is a noticeable gap in comprehensive reviews synthesizing existing evidence to guide public health interventions. This paper aims to address this gap by summarizing recent findings on functional ingredients in food with anti-ageing properties, emphasizing their role in promoting longevity and overall well-being. Functional foods, rich in bioactive compounds, show significant promise in prolonging life and reducing age-related ailments. These compounds effectively mitigate oxidative stress and inflammation, balance immune responses, enhance telomere maintenance, stimulate autophagy, and regulate both mitochondrial function and gut microbiota. Our review not only underscores the potential of anti-ageing functional ingredients but also suggests innovative dietary approaches, potentially transforming the global ageing experience.

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Food Science and Human Wellness

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Cite this article:
Yao W, Wang Y, Kong Z, et al. Integrating Functional Ingredients in Food into Ageing Research: Implications for Lifespan and Healthspan. Food Science and Human Wellness, 2025, https://doi.org/10.26599/FSHW.2025.9250795

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Received: 27 May 2025
Revised: 30 June 2025
Accepted: 09 September 2025
Available online: 21 October 2025

© 2025 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).