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Research Article | Open Access | Just Accepted

Intestinal Flora in Aging: a Scientific Perspective on Food Intervention

Xuewei Ye1,3,†, Yining Guan1,†, Ping Chen2,†, Jiani Zhu1, Yan Liu1, Jintao Chen1, Keqin Zhu1, Zhenyi Jin1, Shuangqi Luo1, Jiaxing Cai1, Xiaoling Xu1( ), Lanjuan Li3( ), Wei Liu4( )

1 Key Laboratory of Artificial Organs and Computational Medicine of Zhejiang Province, Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China

2 Department of Infectious Diseases, Key Laboratory of Artificial Organs and Computational Medicine of Zhejiang Province, Shulan (Hangzhou) Hospital, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China

3 State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, China

4 Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou, China

† These authors have contributed equally to this work.

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Abstract

The intestinal flora serves as a crucial regulator of healthy aging. With aging, the composition and function of the intestinal flora undergoes significant changes that are closely associated with various aging-related diseases. This article reviews the changes in intestinal flora associated with aging and explores the potential of natural foods to improve aging-related diseases through gut microbiota intervention. Specifically, interventions from natural food sources such as probiotics, prebiotics, appropriate dietary supplements, and nutritional intake have shown positive effects on improving gut health and delaying aging. Additionally, the article discusses the effects of different dietary patterns and nutritional restrictions on the intestinal flora and lifespan. Finally, the article summarizes the key findings of gut microbiota in nutritional intervention research on aging, providing evidence and guidance for further exploring the potential of intestinal flora intervention in anti-aging.

Keywords

agingintestinal florafood interventionsdietary supplementsnutritional intake

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Food Science and Human Wellness
DOI: 10.26599/FSHW.2025.9250713

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Cite this article:
Ye X, Guan Y, Chen P, et al. Intestinal Flora in Aging: a Scientific Perspective on Food Intervention. Food Science and Human Wellness, 2025, https://doi.org/10.26599/FSHW.2025.9250713

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Received: 05 September 2024
Revised: 28 February 2025
Accepted: 30 May 2025
Available online: 25 August 2025

© 2025 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).