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Research Article | Open Access

Intestinal flora in aging: a scientific perspective on food intervention

Xuewei Yea,b,1, Yining Guana,1, Ping Chenb,1, Jiani Zhua, Yan Liua, Jintao Chena, Keqin Zhua, Zhenyi Jina, Shuangqi Luoa, Jiaxing Caia, Xiaoling Xua( ), Lanjuan Lic( ), Wei Liud( )
Key Laboratory of Artificial Organs and Computational Medicine of Zhejiang Province, Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou 310015, China
Department of Infectious Diseases, Key Laboratory of Artificial Organs and Computational Medicine of Zhejiang Province, Shulan (Hangzhou) Hospital, Shulan International Medical College, Zhejiang Shuren University, Hangzhou 310015, China
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310015, China
Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou 310015, China

1 These authors have contributed equally to this work.

Peer review under responsibility of Beijing Academy of Food Sciences.

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Highlights

• Aging alters gut microbiota composition, impacting systemic metabolism, immune function, and longevity.

• Natural food interventions can modulate gut microbiota to alleviate aging-related diseases by restoring microbial balance.

• Dietary patterns and supplements support a resilient gut microbiome and promote healthy longevity through anti-inflammatory and antioxidative pathways.

Abstract

The intestinal flora serves as a crucial regulator of healthy aging. As individuals age, the composition and function of the intestinal flora undergo substantial alterations, which are closely linked to various aging-related diseases. This article summarizes the changes in intestinal flora associated with aging and explores the potential of natural foods to ameliorate aging-related diseases via intestinal flora intervention. Specifically, interventions from natural food sources such as probiotics, prebiotics, appropriate dietary supplements, and nutritional intake have shown beneficial effects on improving gut health and delaying the aging process. The article further discusses the impact of various dietary patterns and nutritional restrictions on the intestinal flora composition and lifespan extension. Finally, the article summarizes key findings of intestinal flora in nutritional intervention studies involving intestinal flora and aging, providing evidence and future guidance for further exploring the potential intestinal flora intervention in anti-aging strategies.

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Keywords

AgingIntestinal floraFood interventionsDietary supplementsNutritional intake

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Food Science and Human Wellness
Volume 15 Issue 6,
June 2026
Article number: 9250713
DOI: 10.26599/FSHW.2025.9250713

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Cite this article:
Ye X, Guan Y, Chen P, et al. Intestinal flora in aging: a scientific perspective on food intervention. Food Science and Human Wellness, 2026, 15(6): 9250713. https://doi.org/10.26599/FSHW.2025.9250713

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Received: 05 September 2024
Revised: 28 February 2025
Accepted: 30 May 2025
Published: 23 July 2026
© 2026 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).