Anti-fatigue Properties of Lyophilized Coconut (Cocos nucifera L.) Water Ameliorating the Biochemical Profiles and Inhibiting Oxidative Stress in the Aged Rats

Globally, societies are transitioning towards an aging population, with significant implications for healthcare and quality of life. Naturally derived ergogenic aids offer a promising alternative to enhance physical performance and stamina in the elderly, promoting healthier aging. This proof-of-concept study investigated the ergogenic effects of lyophilized coconut water (LCW) in aging-induced rats using a forced swimming test (FST). Aging was induced in the rats with D-galactose, followed by an 8-week treatment with LCW. Blood serum samples were collected for biochemical and antioxidant enzyme assays. The results revealed that the HD group (2,000 mg/kg) exhibited the highest endurance capacity as measured by the FST. Additionally, blood glucose levels increased significantly, while lactate dehydrogenase (LDH) and creatine kinase (CK) activities, which are biomarkers of muscle damage, were reduced in the HD group. LCW treatment also improved antioxidant enzyme levels and inhibited lipid peroxidation, indicating enhanced oxidative stress management. The improved endurance capacity in the HD group was likely attributed to the bioactive compounds in LCW, which positively influenced energy metabolism. These findings suggested that LCW possessed significant ergogenic properties, making it suitable for the development of natural functional beverages aimed at improving physical performance and overall health in the aging population.