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Article | Open Access

Prenatal multiple micronutrient-fortified balanced energy-protein supplementation and newborn telomere length and mitochondrial DNA content: a randomized controlled efficacy trial in rural Burkina Faso

Giles T. Hanley-Cooka,1( ), Yuri Bastos-Moreiraa,b,1( ), Dries S. Martensc, Trenton Dailey-Chwalibóga, Laeticia Celine Toea,d, Brenda de Koka, Lionel OIivier Ouédraogoa,e, Alemayehu Argawa, Kokeb Tesfamariama,b, Patrick Kolsterena, Lieven Huybregtsa,f, Tim S. Nawrotc,g, Sarah De Saegerb,h, Marthe De Boevreb, Carl Lachata( )
Department of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, Ghent 9000, Belgium
Center of Excellence in Mycotoxicology and Public Health, MYTOXSOUTH® Coordination Unit, Faculty of Pharmaceutical Sciences, Ghent University, Ghent 9000, Belgium
Centre for Environmental Sciences, Hasselt University, Diepenbeek 3590, Belgium
Unité Nutrition et Maladies Métaboliques, Institut de Recherche en Sciences de la Santé (IRSS), Bobo-Dioulasso, 01 BP 545 Burkina Faso
Centre Muraz, Bobo-Dioulasso, 01 BP 390 Burkina Faso
Nutrition, Diets, and Health Unit, Department of Food and Nutrition Policy, International Food Policy Research Institute (IFPRI), Washington DC 20005, USA
Department of Public Health & Primary Care, University of Leuven, Leuven 3000, Belgium
Department of Biotechnology and Food Technology, Faculty of Science, University of Johannesburg, Doornfontein Campus, Gauteng 2028, South Africa

1 These authors contributed equally to the work.

Peer review under responsibility of Beijing Academy of Food Sciences.

Show Author Information

Abstract

Background

Evidence regarding the effectiveness of prenatal nutritional supplements has mainly considered anthropometric pregnancy outcomes. The effect on markers of health and disease, such as offspring telomere length (TL) and mitochondrial DNA content (mtDNAc) is unknown.

Objectives

We assessed the efficacy of maternal multiple micronutrient (MMN)-fortified balanced-energy protein (BEP) and iron-folic acid (IFA) supplementation on newborn TL as a secondary outcome and mtDNAc as a non-declared outcome.

Design

We conducted a randomized controlled trial in rural Burkina Faso, among pregnant females (15-40 years old) enrolled at < 21 weeks of gestation. Mothers received either MMN-fortified BEP and IFA (intervention) or IFA only (control) throughout pregnancy. Whole arterial blood samples were collected from the umbilical cord of 104 control and 90 intervention group infants, respectively. Average relative TL and mtDNAc were measured using quantitative polymerase chain reaction. Linear regression models were fitted to assess TL and mtDNAc differences across trial arms.

Results

We found that a combined daily MMN-fortified BEP supplement and IFA tablet did not affect newborn TL [β =-0.010 (95% CI:-0.057, 0.036); P = 0.662] or mtDNAc [β = 0.065 (95% CI:-0.203, 0.073); P = 0.354], as compared to an IFA tablet alone. These findings were confirmed (P > 0.05) by adjusting the regression models for potential prognostic factors of study outcomes at enrollment. Exploratory analyses indicated higher, but non-significantly different mtDNAc among children born either small-for-gestational age, low birthweight, or preterm.

Conclusion

Newborns from mothers who received daily nutritional supplements across gestation did not have different relative TL or mtDNAc.

Keywords

Balanced-energy proteinBurkina FasoIron-folic acidMitochondrial DNAMultiple micronutrientsRandomized controlled trialTelomere length

Electronic Supplementary Material

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Food Science and Human Wellness
Volume 14 Issue 4,
April 2025
Article number: 9250304
DOI: 10.26599/FSHW.2024.9250304
Cite this article:
Hanley-Cook GT, Bastos-Moreira Y, Martens DS, et al. Prenatal multiple micronutrient-fortified balanced energy-protein supplementation and newborn telomere length and mitochondrial DNA content: a randomized controlled efficacy trial in rural Burkina Faso. Food Science and Human Wellness, 2025, 14(4): 9250304. https://doi.org/10.26599/FSHW.2024.9250304

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Received: 25 April 2023
Revised: 09 June 2024
Accepted: 11 November 2024
Published: 28 February 2025
© 2025 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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