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Research Article | Open Access | Just Accepted

Royal jelly modulates serum lipid metabolism and improves brain lipid profiles in natural aging mice

Lili Chena,b,cLi zhaobGaowei ZhangcZhuozhen LiaHuihui MingcLiangliang QucFangjian NingaLiping Luoa,d( )

a College of Food and Health, Beijing Technology and Business University, Beijing, 100048, China.

b School of Life Science, Jiangxi Science & Technology Normal University, Nanchang, 330013, China.

c School of Life Sciences, Nanchang University, Nanchang, 330031, China.

d Key Laboratory of Geriatric Nutrition and Health Ministry of Education, Beijing Technology and Business University, Beijing, 100048, China.

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Abstract

Royal jelly (RJ) is rich in various nutrients with multiple health-promoting properties. This study aims to evaluate whether RJ can modulate related metabolite in the natural aging mice. Male C57BL/6J mice drank RJ solution daily for 9 months. Determination of serum lipids and pathological analysis exhibited that triglycerides (TG), serum cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) were decreased by 31.15%, 9.96%, and 22.58%, respectively, the morphology of brain nerve cells was also effectively recovered after RJ intervention. Lipidomic analysis showed that RJ could improve the levels of different kinds of lipids in aging mice brain, especially by increasing the content of antioxidant ether ester, and that the ratio of monounsaturated fatty acid (MUFA) to polyunsaturated fatty acid (PUFA) was up by 23.46%, which could alleviate oxidative stress. Moreover, the metabolism of glycerol phospholipids, glycerols, and fatty acids in aging mice could be regulated by RJ. RJ intervention can effectively improve lipid metabolism disorders caused by aging.

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Food Science and Human Wellness
Cite this article:
Chen L, zhao L, Zhang G, et al. Royal jelly modulates serum lipid metabolism and improves brain lipid profiles in natural aging mice. Food Science and Human Wellness, 2024, https://doi.org/10.26599/FSHW.2024.9250071

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Received: 19 June 2023
Revised: 25 July 2023
Accepted: 18 August 2023
Available online: 12 April 2024

© Tsinghua University Press 2024

Reprints and Permission requests may be sought directly from editorial office.
Email: nanores@tup.tsinghua.edu.cn

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