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Article | Open Access

Royal jelly modulates serum lipid metabolism and improves brain lipid profiles in natural aging mice

Lili Chena,b,c, Li Zhaob, Gaowei Zhangc, Zhuozhen Lia, Huihui Mingc, Liangliang Quc, Fangjian Ninga, Liping Luoa,d()
College of Food and Health, Beijing Technology and Business University, Beijing 100048, China
School of Life Science, Jiangxi Science & Technology Normal University, Nanchang 330013, China
School of Life Sciences, Nanchang University, Nanchang 330031, China
Key Laboratory of Geriatric Nutrition and Health Ministry of Education, Beijing Technology and Business University, Beijing 100048, China

Peer review under responsibility of Tsinghua University Press.

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• Royal jelly (RJ) can modulate serum lipid metabolism in natural aging mice.

• RJ effectively improves the natural aging mice brain lipid profile.

• The specific antioxidant ether lipids level is increased after RJ intervention.

• RJ raises the ratio of monounsaturated fatty acids to polyunsaturated fatty acids.

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Abstract

Royal jelly (RJ) is rich in various nutrients with multiple health-promoting properties. This study aims to evaluate whether RJ can modulate related metabolite in the natural aging mice. Male C57BL/6J mice drank RJ solution daily for 9 months. Determination of serum lipids and pathological analysis exhibited that triglycerides, serum cholesterol, and low-density lipoprotein cholesterol were decreased by 31.15%, 9.96%, and 22.58%, respectively, the morphology of brain nerve cells was also effectively recovered after RJ intervention. Lipidomic analysis showed that RJ could improve the levels of different kinds of lipids in aging mice brain, especially by increasing the content of antioxidant ether ester, and that the ratio of monounsaturated fatty acid to polyunsaturated fatty acid was up by 23.46%, which could alleviate oxidative stress. Moreover, the metabolism of glycerol phospholipids, glycerols, and fatty acids in aging mice could be regulated by RJ. RJ intervention can effectively improve lipid metabolism disorders caused by aging.

Keywords

Royal jellyNatural agingBrainLipidomicFatty acids

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Food Science and Human Wellness
Volume 14 Issue 3,
March 2025
Article number: 9250071
DOI: 10.26599/FSHW.2024.9250071
Cite this article:
Chen L, Zhao L, Zhang G, et al. Royal jelly modulates serum lipid metabolism and improves brain lipid profiles in natural aging mice. Food Science and Human Wellness, 2025, 14(3): 9250071. https://doi.org/10.26599/FSHW.2024.9250071
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