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Research Article | Open Access

Reveal the pharmacodynamic substances and mechanism of an edible medicinal plant Rhodiola crenulate in DSS-induced colitis through plasma pharmacochemistry and metabolomics

Yu Penga, Xiaoao Xiaoa, Tingting Jia, Xinyuan Wanga, Yixuan Xua, Jianbo Xiaob,c,d( ), Hui Caoc,d, Zhiyong Chene, Huifan Liuf, Yuanqing Gaoa ( ), Hongxun Taob,g( )
Key Laboratory of Cardiovascular and Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China
School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China
Department of Analytical Chemistry and Food Science, Faculty of Science, University of Vigo, Vigo 36310, Spain
CISPAC, Fontan Building, City of Culture, Santiago de Compostela 15707, Spain
Shaanxi Academy of Traditional Chinese Medicine, Xi'an 710003, China
Guangdong Key Laboratory of Science and Technology of Lingnan Specialty Food, Zhongkai University of Agriculture and Engineering, Guangzhou 510550, China
State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu 610075, China

Peer review under responsibility of Tsinghua University Press.

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Highlights

• 88 compounds were identified in RCE, among which 29 compounds could be absorbed into blood, following by the identification of 8 metabolites.

• A total of 111 characteristic endogenous metabolites were identified.

• Colitis caused the alternation of fatty acid metabolism, steroid hormone biosynthesis and bile acid metabolism.

• The body disposes of the active components in RCE differently under DSS pathological conditions and physiological conditions.

• RCE could prevent colitis by improving fatty acid metabolism and bile acid metabolism.

Abstract

Rhodiola crenulate is the edible medicinal herbal medicine widely used for altitude sickness in China. Interestingly, our previous work has found that R. crenulate extract (RCE) could significantly improve the pathology associated with dextran sulfate sodium-induced colitis. Thus, the current research aims to reveal the pharmacodynamic material basis of RCE, as well as its mechanism against colitis. The chemical characterization of RCE was performed by UHPLC-HR-MS, through which a total of 88 constituents were identified. Meanwhile, our results also found 29 constituents absorbed into blood and 8 metabolized absorbable compounds. The decreased flavonoids prototype and the elevated sulfated products of phenols were observed under pathophysiological conditions of colitis. The metabolomics study revealed that colitis caused the alternation of fatty acid metabolism, steroid hormone biosynthesis and bile acid metabolism. Correspondingly, RCE could prevent colitis by improving fatty acid metabolism and secondary bile acid metabolism.

Keywords

Rhodiola crenulateColitisChemical characterizationPlasma pharmacochemistryMetabolomics

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Food Science and Human Wellness
Volume 13 Issue 4,
July 2024
Pages 2116-2131
DOI: 10.26599/FSHW.2022.9250176

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Cite this article:
Peng Y, Xiao X, Ji T, et al. Reveal the pharmacodynamic substances and mechanism of an edible medicinal plant Rhodiola crenulate in DSS-induced colitis through plasma pharmacochemistry and metabolomics. Food Science and Human Wellness, 2024, 13(4): 2116-2131. https://doi.org/10.26599/FSHW.2022.9250176

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Received: 22 November 2022
Revised: 26 December 2022
Accepted: 24 January 2023
Published: 20 May 2024
© 2024 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).