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Open Access

Causal relationship between circulating vitamin C and 25-hydroxyvitamin D concentrations and common mental disorders - a Mendelian randomization study

Yuanyuan Wanga, Lirong Dongb, Meng Zhaoa, Shiyu Yina, Pan Daa, Dengfeng Xua, Yifei Lua, Jiayue Xiaa, Niannian Wanga, Shaokang Wanga, Guiju Suna( )
Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China
Department of Integrated Service and Management, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China

Peer review under responsibility of Tsinghua University Press.

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Abstract

Mental disorders seriously affect people’s health and social stability. This Mendelian randomization (MR) study was designed to investigate the causal relationship between circulating vitamin C (VC) or 25-hydroxyvitamin D (25(OH)D) levels and mental disorders. The data used for the MR analysis were derived from the summary genome-wide association studies (GWAS) database for VC and 25(OH)D and from the FinnGen consortium for fourteen mental disorders. Based on the inverse variance weighted (IVW) method, we found a potential causal association between circulating VC and anxiety disorders (IVW:OR = 1.139, 95% CI: 1.023-1.269, P = 0.018). However, no causal association was found between VC or 25(OH)D and other mental disorders (P > 0.05). In the reverse MR analysis, individuals with Alzheimer’s disease was causally associated with higher concentrations of circulating VC (P = 0.012), while individuals with anxiety disorders had a negative association between the concentrations of 25(OH)D (P = 0.012). However, the current evidence does not support a causal relationship between VC or 25(OH)D and other mental disorders. In addition, there was no causal association between circulating VC and 25(OH)D (P > 0.05). Future studies are needed to confirm these findings and to elucidate the mechanisms of potential causality.

Keywords

Circulating vitamin C25-Hydroxyvitamin DMental disorderMendelian randomization

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References

[1]
World Health Organization, World mental health report: transforming mental health for all. https://www.who.int/publications/i/item/9789240049338. (accessed on 19 Aug 2022).
[2]

A. Lora, F. Hanna, D. Chisholm, Mental health service availability and delivery at the global level: an analysis by countries’ income level from WHO’s Mental Health Atlas 2014, Epidemiol Psychiatr Sci. (2017) 1-12. https://doi.org/10.1017/S2045796017000075.
Crossref Google Scholar
[3]

M. Kumar, V. Nyongesa, M. Kagoya, et al., Mapping services at two Nairobi County primary health facilities: identifying challenges and opportunities in integrated mental health care as a Universal Health Coverage (UHC) priority. Ann. Gen. Psychiatry, 20 (2021) 37. https://doi.org/10.1186/s12991-021-00359-x.
Crossref Google Scholar
[4]

M. Trøstheim, M. Eikemo, R. Meir, et al., Assessment of anhedonia in adults with and without mental illness: a systematic review and meta-analysis, JAMA Netw Open. 3 (2020) e2013233. https://doi.org/10.1001/jamanetworkopen.2020.13233.
Crossref Google Scholar
[5]

J. Rehm, K.D. Shield, Global burden of disease and the impact of mental and addictive disorders, Curr. Psychiatry Rep. 21 (2019) 10. https://doi.org/10.1007/s11920-019-0997-0.
Crossref Google Scholar
[6]
World Health Organization, Mental health. https://www.who.int/health-topics/mental-health#tab=tab_1. (accessed on 19 Aug 2022).
[7]
GBD 2019 Diseases and Injuries Collaborators, Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019, Lancet 396 (2020) 1204-1222. https://doi.org/10.1016/S0140-6736(20)30925-9.
[8]

F. Charlson, M.V. Ommeren, A. Flaxman, et al., New WHO prevalence estimates of mental disorders in conflict settings: a systematic review and meta-analysis, Lancet 394 (2019) 240-248. https://doi.org/10.1016/S0140-6736(19)30934-1.
Crossref Google Scholar
[9]

E.A. Holmes, R.C. O’Connor, V.H. Perry, et al., Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science, Lancet Psychiatry. 7 (2020) 547-560. https://doi.org/10.1016/S2215-0366(20)30168-1.
Crossref Google Scholar
[10]
COVID-19 Mental Disorders Collaborators, Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic, Lancet 398 (2021) 1700-1712. https://doi.org/10.1016/S0140-6736(21)02143-7.
[11]

O. Plana-Ripoll, C.B. Pedersen, Y. Holtz, et al., Exploring comorbidity within mental disorders among a danish national population, JAMA Psychiatry 76(3) 2019 259-270.
Google Scholar
[12]

M Marshall, The hidden links between mental disorders, Nature 581 (2020) 19-21. https://doi.org/10.1001/jamapsychiatry.2018.3658.
Crossref Google Scholar
[13]

M. Lindblad, P. Tveden-Nyborg J. Lykkesfeldt, Regulation of vitamin C homeostasis during deficiency, Nutrients 5 (2013) 2860-2879. https://doi.org/10.3390/nu5082860.
Crossref Google Scholar
[14]

B. Moritz, A.E. Schmitz, A.L.S. Rodrigues, et al., The role of vitamin C in stress-related disorders, J. Nutr. Biochem. 85 (2020) 108459. https://doi.org/10.1016/j.jnutbio.2020.108459.
Crossref Google Scholar
[15]

Y.F. Wang, X.J. Liu, L. Robitaille, et al., Effects of vitamin C and vitamin D administration on mood and distress in acutely hospitalized patients, Am. J. Clin. Nutr. 98 (2013) 705-711. https://doi.org/10.3945/ajcn.112.056366.
Crossref Google Scholar
[16]

D. Plevin, C. Galletly, The neuropsychiatric effects of vitamin C deficiency: a systematic review, BMC Psychiatry. 20 (2020) 315. https://doi.org/10.1186/s12888-020-02730-w.
Crossref Google Scholar
[17]

A. Sahraian, A. Ghanizadeh, F. Kazemeini, Vitamin C as an adjuvant for treating major depressive disorder and suicidal behavior, a randomized placebo-controlled clinical trial, Trials 16 (2015) 94. https://doi.org/10.1186/s13063-015-0609-1.
Crossref Google Scholar
[18]

X.Y. Cui, J.J. McGrath, T.H.J. Burne, et al., Vitamin D and schizophrenia: 20 years on, Mol. Psychiatry. 26 (2021) 2708-2720. https://doi.org/10.1038/s41380-021-01025-0.
Crossref Google Scholar
[19]

J.L. Zhu, W.W. Luo, X. Cheng, et al., Vitamin D deficiency and schizophrenia in adults: a systematic review and meta-analysis of observational studies, Psychiatry Res. 288 (2020) 112959. https://doi.org/10.1016/j.psychres.2020.112959.
Crossref Google Scholar
[20]

J. Tsiglopoulos, N. Pearson, N. Mifsud, et al., The association between vitamin D and symptom domains in psychotic disorders: a systematic review, Schizophr. Res. 237 (2021) 79-92. https://doi.org/10.1016/j.schres.2021.08.001.
Crossref Google Scholar
[21]

J. Adamson, J. Lally, F. Gaughran, et al., Correlates of vitamin D in psychotic disorders: a comprehensive systematic review, Psychiatry Res. 249 (2017) 78-85. https://doi.org/10.1016/j.psychres.2016.12.052.
Crossref Google Scholar
[22]

J. Wei, G.H. Lei, L. Fu, et al., Association between dietary vitamin C intake and non-alcoholic fatty liver disease: a cross-sectional study among middle-aged and older adults, PLoS ONE 11 (2016) e0147985. https://doi.org/10.1371/journal.pone.0147985.
Crossref Google Scholar
[23]

D. Jahn, D. Dorbath, S. Kircher, et al., Beneficial effects of vitamin D treatment in an obese mouse model of non-alcoholic steatohepatitis, Nutrients 11 (2019) 77. https://doi.org/10.3390/nu11010077.
Crossref Google Scholar
[24]

W. Dong, C. Tian, Y. Jiao, et al., Multiple genome analyses reveal key genes in vitamin C and vitamin D synthesis and transport pathways are shared, Sci. Rep. 9 (2019) 16811. https://doi.org/10.1038/s41598-019-53074-9.
Crossref Google Scholar
[25]

C.A. Emdin, A.V. Khera, S. Kathiresan, Mendelian randomization, JAMA, 318 (2017) 1925-1926. https://doi.org/10.1001/jama.2017.17219.
Crossref Google Scholar
[26]

S. Burgess, S. G. Thompson, Mendelian randomization: methods for causal inference using genetic variants, Taylor & Francis Group, New York, 2015.
[27]

J.S. Zheng, J. Luan, E. Sofianopoulou, et al., Plasma vitamin C and type 2 diabetes: genome-wide association study and mendelian randomization analysis in european populations, Diabetes Care 44 (2021) 98-106. https://doi.org/10.2337/dc20-1328.
Crossref Google Scholar
[28]

J.A. Revez, T. Lin, Z. Qiao, et al., Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration, Nat. Commun. 11 (2020) 1647. https://doi.org/10.1038/s41467-020-15421-7.
Crossref Google Scholar
[29]

S.G Davey, G. Hemani, Mendelian randomization: genetic anchors for causal inference in epidemiological studies, Hum. Mol. Genet. 23 (2014) R89-R98. https://doi.org/10.1093/hmg/ddu328.
Crossref Google Scholar
[30]

V.W. Skrivankova, R.C. Richmond, B.A.R. Woolf, et al., Strengthening the reporting of observational studies in epidemiology using mendelian randomization: the STROBE-MR statement, JAMA 326 (2021) 1614-1621. https://doi.org/10.1001/jama.2021.18236.
Crossref Google Scholar
[31]

M.I. Kurki, J. Karjalainen, P. Palta, et al., FinnGen: unique genetic insights from combining isolated population and national health register data, medRxiv. 3 (2022) 22271360. https://doi.org/10.1101/2022.03.03.22271360.
Crossref Google Scholar
[32]

N.M. Davies, M.V. Holmes, G.S. Davey, Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians, BMJ 362 (2018) k601. https://doi.org/10.1136/bmj.k601.
Crossref Google Scholar
[33]

N. Papadimitriou, N. Dimou, K.K. Tsilidis, et al., Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis, Nat. Commun. 11 (2020) 597. https://doi.org/10.1038/s41467-020-14389-8.
Crossref Google Scholar
[34]

S. Burgess, A. Butterworth, S.G. Thompson, Mendelian randomization analysis with multiple genetic variants using summarized data, Genet. Epidemiol. 37 (2013) 658-665. https://doi.org/10.1002/gepi.21758.
Crossref Google Scholar
[35]

J. Bowden J, G.S. Davey, S. Burgess. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression, Int. J. Epidemiol. 44 (2015) 512-525. https://doi.org/10.1093/ije/dyv080.
Crossref Google Scholar
[36]

J. Bowden, G.S. Davey, P.C. Haycock, et al., Consistent estimation in mendelian randomization with some invalid instruments using a weighted median estimator, Genet. Epidemiol. 40 (2016) 304-314. https://doi.org/10.1002/gepi.21965.
Crossref Google Scholar
[37]

Z.H. Zhu, F.T. Zhang, H. Hu, et al., Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets, Nat. Genet. 48 (2016) 481-487. https://doi.org/10.1038/ng.3538.
Crossref Google Scholar
[38]

M. Verbanck, C.Y. Chen, B. Neale, et al., Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases, Nat. Genet. 50 (2018) 693-698. https://doi.org/10.1038/s41588-018-0099-7.
Crossref Google Scholar
[39]

G. Hemani, J. Zheng, B. Elsworth, et al., The MR-Base platform supports systematic causal inference across the human phenome, eLife 7 (2018) e34408. https://doi.org/10.7554/eLife.34408.
Crossref Google Scholar
[40]

G. Hemani, J. Bowden, G.S. Davey, Evaluating the potential role of pleiotropy in Mendelian randomization studies, Hum. Mol. Genet. 27 (2018) R195-R208. https://doi.org/10.1093/hmg/ddy163.
Crossref Google Scholar
[41]

Z. Mazloom, M. Ekramzadeh, N. Hejazi, Efficacy of supplementary vitamins C and E on anxiety, depression and stress in type 2 diabetic patients: a randomized, single-blind, placebo-controlled trial, Pak. J. Biol. Sci. 16 (2013) 1597-1600. https://doi.org/10.3923/pjbs.2013.1597.1600.
Crossref Google Scholar
[42]

B.D. Fletcher, J.A.M. Flett, S.R. Wickham, et al., Initial evidence of variation by ethnicity in the relationship between vitamin C status and mental states in young adults, Nutrients 13 (2021) 792. https://doi.org/10.3390/nu13030792.
Crossref Google Scholar
[43]

G.G. Fillenbaum, M.N. Kuchibhatla, J.T. Hanlon, et al., Dementia and Alzheimer’s disease in community-dwelling elders taking vitamin C and/or vitamin E, Ann. Pharmacother. 39 (2005) 2009-2014. https://doi.org/10.1345/aph.1G280.
Crossref Google Scholar
[44]

S.L. Gray, M.L. Anderson, P.K. Crane, et al., Antioxidant vitamin supplement use and risk of dementia or Alzheimer’s disease in older adults, J. Am. Geriatr. Soc. 56 (2008) 291-295. https://doi.org/10.1111/j.1532-5415.2007.01531.x.
Crossref Google Scholar
[45]

J. Firth, S.B. Teasdale, K. Allott, et al., The efficacy and safety of nutrient supplements in the treatment of mental disorders: a meta-review of meta-analyses of randomized controlled trials, World Psychiatry 18 (2019) 308-324. https://doi.org/10.1002/wps.20672.
Crossref Google Scholar
[46]

Y. Sharma, A. Popescu, C. Horwood, et al., Relationship between Vitamin C deficiency and cognitive impairment in older hospitalised patients: a cross-sectional study, Antioxidants. 11 (2022) 463. https://doi.org/10.3390/antiox11030463.
Crossref Google Scholar
[47]

M. Amr, A. El-Mogy, T. Shams, et al., Efficacy of vitamin C as an adjunct to fluoxetine therapy in pediatric major depressive disorder: a randomized, double-blind, placebo-controlled pilot study, Nutr. J. 12 (2013) 31. https://doi.org/10.1186/1475-2891-12-31.
Crossref Google Scholar
[48]

S.S.D. Lopes, B. Vellas, S. Elemans, et al., Plasma nutrient status of patients with Alzheimer’s disease: systematic review and meta-analysis, Alzheimers Dement. 10 (2014) 485-502. https://doi.org/10.1016/j.jalz.2013.05.1771.
Crossref Google Scholar
[49]

M.C.D. Wilde, B. Vellas, E. Girault, et al., Lower brain and blood nutrient status in Alzheimer’s disease: results from meta-analyses, Alzheimers Dement. 3 (2017) 416-431. https://doi.org/10.1016/j.trci.2017.06.002.
Crossref Google Scholar
[50]

D.A. Lawlor, R.M. Harbord, J.A. Sterne, et al., Mendelian randomization: using genes as instruments for making causal inferences in epidemiology, Stat. Med. 27 (2008) 1133-1163. https://doi.org/10.1002/sim.3034.
Crossref Google Scholar
[51]

L. Wang, B. Gao, Y. Fan, et al., Mendelian randomization under the omnigenic architecture, Brief Bioinform. 22 (2021) bbab322. https://doi.org/10.1093/bib/bbab322.
Crossref Google Scholar
[52]

V. Shivakumar, S.V. Kalmady, A.C. Amaresha, et al., Serum vitamin D and hippocampal gray matter volume in schizophrenia, Psychiatry Res. 233 (2015) 175-179. https://doi.org/10.1016/j.pscychresns.2015.06.006.
Crossref Google Scholar
[53]

J.J. Cannell, Vitamin D and autism, what’s new? Rev. Endocr. Metab. Disord. 18 (2017) 183-193. https://doi.org/10.1007/s11154-017-9409-0.
Crossref Google Scholar
[54]

A.M. Tolppanen, A. Sayers, W.D. Fraser, et al., The association of serum 25-hydroxyvitamin D3 and D2 with depressive symptoms in childhood: a prospective cohort study, J. Child Psychol. Psychiatry 53 (2012) 757-766. https://doi.org/10.1111/j.1469-7610.2011.02518.x.
Crossref Google Scholar
[55]

D. Guzek, A. Kołota, K. Lachowicz, et al., Association between vitamin D supplementation and mental health in healthy adults: a systematic review, J. Clin. Med. 10 (2021) 5156. https://doi.org/10.3390/jcm10215156.
Crossref Google Scholar
[56]

O.I. Okereke, C.F. Reynolds CF, D. Mischoulon, et al., Effect of long-term vitamin D3 supplementation vs placebo on risk of depression or clinically relevant depressive symptoms and on change in mood scores: a randomized clinical trial, JAMA. 324 (2020) 471-480. https://doi.org/10.1001/jama.2020.10224.
Crossref Google Scholar
[57]

L. Libuda, B.H. Laabs, C. Ludwig, et al., Vitamin D and the risk of depression: a causal relationship? Findings from a mendelian randomization study, Nutrients 11 (2019) 1085. https://doi.org/10.3390/nu11051085.
Crossref Google Scholar
[58]

G. Ashdown-Franks, J. Firth, R. Carney, et al., Exercise as medicine for mental and substance use disorders: a meta-review of the benefits for neuropsychiatric and cognitive outcomes, Sports Med. 50 (2020) 151-170. https://doi.org/10.1007/s40279-019-01187-6.
Crossref Google Scholar
[59]

M. Molendijk, P. Molero, F. Ortuño Sánchez-Pedreño, et al., Diet quality and depression risk: a systematic review and dose-response meta-analysis of prospective studies, J. Affect Disord. 226 (2018) 346-354. https://doi.org/10.1016/j.jad.2017.09.022.
Crossref Google Scholar
[60]

S.B. Teasdale, P.B. Ward, K. Samaras, et al., Dietary intake of people with severe mental illness: systematic review and meta-analysis, Br. J. Psychiatry. 214 (2019) 251-259. https://doi.org/10.1192/bjp.2019.20.
Crossref Google Scholar
Food Science and Human Wellness
Volume 13 Issue 4,
July 2024
Pages 1877-1885
DOI: 10.26599/FSHW.2022.9250156
Cite this article:
Wang Y, Dong L, Zhao M, et al. Causal relationship between circulating vitamin C and 25-hydroxyvitamin D concentrations and common mental disorders - a Mendelian randomization study. Food Science and Human Wellness, 2024, 13(4): 1877-1885. https://doi.org/10.26599/FSHW.2022.9250156

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Received: 21 November 2022
Revised: 04 January 2023
Accepted: 23 January 2023
Published: 20 May 2024
© 2024 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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