Journal Home > Volume 13 , Issue 3
Food Science and Human Wellness 2024, 13(3): 1543-1555 https://doi.org/10.26599/FSHW.2022.9250130
Research Article | Open Access | Issue | Published: 08 February 2024

Hypoglycemic effect and the mechanism of action of a polysaccharide from sweet corncob in a high-fat diet and streptozotocin-induced diabetic mice

Show Author's Information Xin Wang,( ),  Weiye Xiu,  Ye Han,  Zhili Wang,  Yu Luo,  Yongqiang Ma( )
Heilongjiang Provincial Key Laboratory of Cereals and Comprehensive Processing of Cereal Resources, College of Food Engineering, Harbin University of Commerce, Harbin 150028, China

Peer review under responsibility of Tsinghua University Press.

Keywords:
Type 2 diabetes, Signal pathway, Sweet corn cob polysaccharide, 5’-AMP-activated protein kinase (AMPK)
Cite this article:
Wang X, Xiu W, Han Y, et al. Hypoglycemic effect and the mechanism of action of a polysaccharide from sweet corncob in a high-fat diet and streptozotocin-induced diabetic mice. Food Science and Human Wellness, 2024, 13(3): 1543-1555. https://doi.org/10.26599/FSHW.2022.9250130
Download citation
EndNote(RIS)
BibTeX

543

Views

140

Downloads

Citations

0

Crossref

0

WoS

0

Scopus

0

CSCD

Abstract Full text Electronic supplementary material About this article

Type 2 diabetes mellitus (T2DM) is a metabolic disease caused by a glycolipid metabolism disorder and islet β-cell dysfunction. SCP-80-I is a biologically active water-soluble polysaccharide isolated from sweet corncob, an agricultural byproduct. The hypoglycemic effects of SCP-80-I on T2DM mice and its mechanisms were investigated in this study. SCP-80-I was found to significantly reduce blood glucose and lipid deposition levels in T2DM mice, as well as decrease serum leptin and increase adiponectin secretion. Interestingly, real time-polymerase chain reaction (RT-PCR) and Western blotting results revealed that SCP-80-I could regulate the expression of several glycolipid metabolisms and insulin secretion genes and proteins, including 5’-AMP-activated protein kinase (AMPK), carnitine palmitoyltransferase I (CPT1), and acetyl coenzyme A carboxylase (ACC) in the liver and AMPK, sirtuin 1 (Sirt1), peroxisome proliferator-activated receptorycoactivator-1 (PGC-1α), and uncoupling protein 2 (UCP2) in the pancreas. To have a hypoglycemic effect, SCP-80-I regulated glycolipid metabolism and islet cell function in the liver by regulating the AMPK/ACC/CPT1 signaling pathway and the AMPK/Sirt1/PGC-1α and AMPK/Sirt1/UCP2 signaling pathways. These findings improve our understanding of polysaccharides derived from sweet corncob and the use of SCP-80-I in the production of hypoglycemic foods.


menu
Abstract
Full text
Outline
Electronic supplementary material
About this article

Hypoglycemic effect and the mechanism of action of a polysaccharide from sweet corncob in a high-fat diet and streptozotocin-induced diabetic mice

Show Author's information Xin Wang,( ), Weiye Xiu, Ye Han, Zhili Wang, Yu Luo, Yongqiang Ma( )
Heilongjiang Provincial Key Laboratory of Cereals and Comprehensive Processing of Cereal Resources, College of Food Engineering, Harbin University of Commerce, Harbin 150028, China

Peer review under responsibility of Tsinghua University Press.

Abstract

Type 2 diabetes mellitus (T2DM) is a metabolic disease caused by a glycolipid metabolism disorder and islet β-cell dysfunction. SCP-80-I is a biologically active water-soluble polysaccharide isolated from sweet corncob, an agricultural byproduct. The hypoglycemic effects of SCP-80-I on T2DM mice and its mechanisms were investigated in this study. SCP-80-I was found to significantly reduce blood glucose and lipid deposition levels in T2DM mice, as well as decrease serum leptin and increase adiponectin secretion. Interestingly, real time-polymerase chain reaction (RT-PCR) and Western blotting results revealed that SCP-80-I could regulate the expression of several glycolipid metabolisms and insulin secretion genes and proteins, including 5’-AMP-activated protein kinase (AMPK), carnitine palmitoyltransferase I (CPT1), and acetyl coenzyme A carboxylase (ACC) in the liver and AMPK, sirtuin 1 (Sirt1), peroxisome proliferator-activated receptorycoactivator-1 (PGC-1α), and uncoupling protein 2 (UCP2) in the pancreas. To have a hypoglycemic effect, SCP-80-I regulated glycolipid metabolism and islet cell function in the liver by regulating the AMPK/ACC/CPT1 signaling pathway and the AMPK/Sirt1/PGC-1α and AMPK/Sirt1/UCP2 signaling pathways. These findings improve our understanding of polysaccharides derived from sweet corncob and the use of SCP-80-I in the production of hypoglycemic foods.

Keywords: Type 2 diabetes, Signal pathway, Sweet corn cob polysaccharide, 5’-AMP-activated protein kinase (AMPK)

References(64)

[1]

K. Kalliopi, M. Yannis, The role of lifestyle, eating habits and social environment in the prevention and treatment of type 2 diabetes and hypertension, Nutrients 13(5) (2021) 1460. https://doi.org/10.3390/NU13051460.
DOI Google Scholar
[2]

C. Hu, W. Jia, Diabetes in China: epidemiology and genetic risk factors and their clinical utility in personalized medication, Diabetes 67(1) (2018) 3-11. https://doi.org/10.2337/dbi17-0013.
DOI Google Scholar
[3]

G. Marta, H. Adela, T. Estefanía, et al., Metabolomics in prediabetes and diabetes: a systematic review and meta-analysis, Diabetes Care 39(5) (2016) 833-846. https://doi.org/10.2337/dc15-2251.
DOI Google Scholar
[4]

J. Marín-Peñalver, I. Martín-Timón, C. Sevillano-Collantes, et al., Update on the treatment of type 2 diabetes mellitus, World J. Diabetes 7(17) (2016) 354. https://doi.org/10.4239/wjd.v7.i17.35.
DOI Google Scholar
[5]

E. Stuermer, B. Klara, N. Terberger, et al., Side effects of frequently used oral antidiabetics on wound healing in vitro, Naunyn-Schmiedeberg’s Arch. Pharmacol. 392(3) (2019) 371-380. https://doi.org/10.1007/s00210-018-01597-9.
DOI Google Scholar
[6]

H. David, S. Alan, K. Andrew, Effects of glucose-lowering drugs on body weight in type 2 diabetes, Prescriber 22(19) (2011) 32-42. https://doi.org/10.1002/psb.810.
DOI Google Scholar
[7]

H. Wang, Q. Li, N. Yu, et al., Dendrobium huoshanense polysaccharide regulates hepatic glucose homeostasis and pancreatic β-cell function in type 2 diabetic mice, Carbohydr. Polym. 211 (2019) 39-48. https://doi.org/10.1016/j.carbpol.2019.01.101.
DOI Google Scholar
[8]

C. Zhang, H. Chen, W. Bai, Characterization of Momordica charantia L. polysaccharide and its protective effect on pancreatic cells injury in STZ-induced diabetic mice, Int. J. Biol. Macromol. 115 (2018) 45-52. https://doi.org/10.1016/j.ijbiomac.2018.04.039.
DOI Google Scholar
[9]

Y. Zhang, C. Ren, G. Lu, et al., Purification, characterization and anti-diabetic activity of a polysaccharide from mulberry leaf, Regul. Toxicol. Pharmacol. 70(3) (2014) 687-695. https://doi.org/10.1016/j.yrtph.2014.10.006.
DOI Google Scholar
[10]

R. Jia, Z. Li, Z. Ou, et al., Physicochemical characterization of Hizikia fusiforme polysaccharide and its hypoglycemic activity via mediating insulin-stimulated blood glucose utilization of skeletal muscle in type 2 diabetic rats, Chem. Biodiversity 17(10) (2020) e2000367. https://doi.org/10.1002/cbdv.202000367.
DOI Google Scholar
[11]

Z. Wang, Z. Wang, W. Huang, et al., Antioxidant and anti-inflammatory activities of an anti-diabetic polysaccharide extracted from Gynostemma pentaphyllum herb, Int. J. Biol. Macromol. 145(C) (2020) 484-491. https://doi.org/10.1016/j.ijbiomac.2019.12.213.
DOI Google Scholar
[12]

H. Zhao, Q. Lai, J. Zhang, et al., Antioxidant and hypoglycemic effects of acidic-extractable polysaccharides from Cordyceps militaris on type 2 diabetes mice, Oxid. Med. Cell. Longevity 2018 (2018) 9150807. https://doi.org/10.1155/2018/9150807.
DOI Google Scholar
[13]

J. Li, M. Luo, Z. Luo, et al., Transcriptome profiling reveals the anti-diabetic molecular mechanism of Cyclocarya paliurus polysaccharides, J. Funct. Foods 55 (2019) 1-8. https://doi.org/10.1016/j.jff.2018.12.039.
DOI Google Scholar
[14]

F. Yu, Y. Wang, Y. Teng, et al., Interaction and inhibition of a Ganoderma lucidum proteoglycan on PTP1B activity for anti-diabetes, ACS Omega 6(44) (2021) 29804-29813. https://doi.org/10.1021/ACSOMEGA.1C04244.
DOI Google Scholar
[15]

P. Gong, D. Cui, Y. Guo, et al. A novel polysaccharide obtained from Siraitia grosvenorii alleviates inflammatory responses in a diabetic nephropathy mouse model via the TLR4-NF-κB pathway, Food Funct. 12(19) (2021) 9054-9065. https://doi.org/10.1039/D1FO01182K.
DOI Google Scholar
[16]

X. Wang, Z. Wang, K. Zhang, et al., Effects of sweet corncob polysaccharide on pancreatic protein expression in type 2 diabetic rats, J. Funct. Foods 88 (2022) 104908. https://doi.org/10.1016/J.JFF.2021.104908.
DOI Google Scholar
[17]

Z. Wang, X. Wang, W. Xiu, et al., Characteristics of selenium polysaccharide from sweet corncob and its effects on non-enzymatic glycosylation in vivo, Appl. Biol. Chem. 65(1) (2022) 1-15. https://doi.org/10.1186/s13765-022-00678-x.
DOI Google Scholar
[18]

X. Xu, C. Fang, Y. Wang, et al., Integrating network pharmacology and metabolomics to elucidate the mechanism of action of Huang Qin decoction for treament of diabetic liver injury, Front. Pharmacol. 13 (2022) 899043. https://doi.org/10.3389/FPHAR.2022.899043.
DOI Google Scholar
[19]

Z. Li, R. Jia, D. Luo, et al., The positive effects and underlying mechanisms of Undaria pinnatifida polysaccharides on type 2 diabetes mellitus in rats, Food Funct. 12 (2021) 11898-11912. https://doi.org/10.1039/d1fo01838.
DOI Google Scholar
[20]

P. Suthamwong, M. Minami, T. Okada, et al., Administration of mulberry leaves maintains pancreatic β-cell mass in obese/type 2 diabetes mellitus mouse model, BMC Complement. Med. Ther. 20(1) (2020) 136. https://doi.org/10.1186/s12906-020-02933-4.
DOI Google Scholar
[21]

S. Shivani, S. Priya, P. Harsh, et al., Incretin hormones receptor signaling plays the key role in antidiabetic potential of PTY-2 against STZ-induced pancreatitis, Biomed. Pharmacother. 97 (2018) 330-338. https://doi.org/10.1016/j.biopha.2017.10.071.
DOI Google Scholar
[22]

P. Zhao, Q. Ming, J. Qiu, et al., Ethanolic extract of folium sennae mediates the glucose uptake of L6 cells by GLUT4 and Ca2+, Molecules 23(11) (2018) 2934. https://doi.org/10.3390/molecules23112934.
DOI Google Scholar
[23]

Q. Guo, Z. Chen, R. Santhanam, et al., Hypoglycemic effects of polysaccharides from corn silk (Maydis stigma) and their beneficial roles via regulating the PI3K/Akt signaling pathway in L6 skeletal muscle myotubes, Int. J. Biol. Macromol. 121 (2018) 981-988. https://doi.org/10.1016/j.ijbiomac.2018.10.100.
DOI Google Scholar
[24]

Z. Bai, J. Meng, X. Huang, et al., Comparative study on antidiabetic function of six legume crude polysaccharides, Int. J. Biol. Macromol. 154(C) (2020) 25-30. https://doi.org/10.1016/j.ijbiomac.2020.03.072.
DOI Google Scholar
[25]

M. Ivan, V. Rafael, A. Irene, et al., Amylin as a potential link between type 2 diabetes and alzheimer disease, Ann. Neurol. 86(4) (2019) 539-551. https://doi.org/10.1002/ana.25570.
DOI Google Scholar
[26]

Y. Yin, Z. Zheng, Z. Jiang. Effects of lycopene on metabolism of glycolipid in type 2 diabetic rats, Biomed. Pharmacother. 109 (2019) 2070-2077. https://doi.org/10.1016/j.biopha.2018.07.100.
DOI Google Scholar
[27]

Y. Li, D. Chen, C. Xu, et al., Glycolipid metabolism and liver transcriptomic analysis of the therapeutic effects of pressed degreased walnut meal extracts on type 2 diabetes mellitus rats, Food Funct. 11(6) (2020) 5538-5552. https://doi.org/10.1039/d0fo00670j.
DOI Google Scholar
[28]

R. Wang, L. Zhang, Q. Zhang, et al., Glycolipid metabolism and metagenomic analysis of the therapeutic effect of a phenolics-rich extract from noni fruit on type 2 diabetic mice, J. Agric. Food Chem. 70 (2022) 2876-2888. https://doi.org/10.1021/acs.jafc.1c07441.
DOI Google Scholar
[29]

H. Balandrano, C. Zhi, H. Ruth, et al., Hypoglycemic and hypolipidemic effects of blueberry anthocyanins by AMPK activation: in vitro and in vivo studies, Redox Biol. 46 (2021) 102100. https://doi.org/10.1016/j.redox.2021.102100.
DOI Google Scholar
[30]

Y. Zhou, N. Xu, X. Zhang, et al., Chrysin improves glucose and lipid metabolism disorders by regulating the AMPK/PI3K/AKT signaling pathway in insulin-resistant HepG2 cells and HFD/STZ-induced C57BL/6J mice, J. Agric. Food Chem. 20 (2021) 69. https://doi.org/10.1021/ACS.JAFC.1C01109.
DOI Google Scholar
[31]

M. Wang, H. Ma, S. Guan, et al., Astaxanthin from Haematococcus pluvialis alleviates obesity by modulating lipid metabolism and gut microbiota in mice fed a high-fat diet, Food Funct. 12(20) (2021) 9719-9738. https://doi.org/10.1039/D1FO01495A.
DOI Google Scholar
[32]

W. Lin, Y. Jin, X. Hu, et al., AMPK/PGC-1α/GLUT4-mediated effect of icariin on hyperlipidemia-induced non-alcoholic fatty liver disease and lipid metabolism disorder in mice, Biochemistry (Moscow) 86(11) (2021) 1407-1417. https://doi.org/10.1134/S0006297921110055.
DOI Google Scholar
[33]

Y. Wu, F. Zhou, H. Jiang, et al., Chicory (Cichorium intybus L.) polysaccharides attenuate high-fat diet induced non-alcoholic fatty liver disease via AMPK activation, Int. J. Biol. Macromol. 118 (2018) 886-895. https://doi.org/10.1016/j.ijbiomac.2018.06.140.
DOI Google Scholar
[34]

N. Xu, Y. Zhou, X. Lu, et al., Auricularia auricula-judae (Bull.) polysaccharides improve type 2 diabetes in HFD/STZ-induced mice by regulating the AKT/AMPK signaling pathways and the gut microbiota, J. Food Sci. 86(12) (2021) 5479-5494. https://doi.org/10.1111/1750-3841.15963.
DOI Google Scholar
[35]

F. Zhao, K. Zhu, Q. Zhao, et al., Holothuria leucospilota polysaccharides alleviate liver injury via AMPK and NF-κB signaling pathways in type 2 diabetic rats, J. Funct. Foods 85 (2021) 104657. https://doi.org/10.1016/J.JFF.2021.104657.
DOI Google Scholar
[36]

L. Wang, C. Li, Q. Huang, et al., Polysaccharide from Rosa roxburghii Tratt fruit attenuates hyperglycemia and hyperlipidemia and regulates colon microbiota in diabetic db/db mice, J. Agric. Food Chem. 68(1) (2020) 147-159. https://doi.org/10.1021/acs.jafc.9b06247.
DOI Google Scholar
[37]

R. Ren, J. Gong, Y. Zhao, et al., Sulfated polysaccharide from Enteromorpha prolifera suppresses SREBP-1c and ACC expression to lower serum triglycerides in high-fat diet-induced hyperlipidaemic rats, J. Funct. Foods 40 (2018) 722-728. https://doi.org/10.1016/j.jff.2017.12.010.
DOI Google Scholar
[38]

P. Li, Z. Xia, W. Kong, et al., Exogenous L-carnitine ameliorates burn-induced cellular and mitochondrial injury of hepatocytes by restoring CPT1 activity, Nutr. Metab. 18(1) (2021) 65-65. https://doi.org/10.1186/S12986-021-00592-X.
DOI Google Scholar
[39]

L. Dong, X. Han, X. Tao, et al., Protection by the total flavonoids from Rosa laevigata Michx fruit against lipopolysaccharide-induced liver injury in mice via modulation of FXR signaling, Foods 7(6) (2018) 88-88. https://doi.org/10.3390/foods7060088.
DOI Google Scholar
[40]

S. Zhao, S. Zhang, W. Zhang, et al., First demonstration of protective effects of purified mushroom polysaccharide-peptides against fatty liver injury and the mechanisms involved, Sci. Rep. 9(1) (2019) 13725. https://doi.org/10.1038/s41598-019-49925-0.
DOI Google Scholar
[41]

M. Xin, Y. Sun, H. Chen, et al., Propylene glycol guluronate sulfate (PGGS) reduces lipid accumulation via AMP-activated kinase activation in palmitate-induced HepG2 cells, Int. J. Biol. Macromol. 114 (2018) 26-34. https://doi.org/10.1016/j.ijbiomac.2018.03.068.
DOI Google Scholar
[42]

L. Carneiro, M. Asrih, C. Repond, et al., AMPK activation caused by reduced liver lactate metabolism protects against hepatic steatosis in MCT1 haploinsufficient mice, Mol. Metab. 6(12) (2017) 1625-1633. https://doi.org/10.1016/j.molmet.2017.10.005.
DOI Google Scholar
[43]

Q. Li, X. Lai, L. Sun, et al., Antiobesity and anti-inflammation effects of Hakka stir-fried tea of different storage years on high-fat diet-induced obese mice model via activating the AMPK/ACC/CPT1 pathway, Food Nutr. Res. 64 (2020) 1681. https://doi.org/10.29219/fnr.v64.1681.
DOI Google Scholar
[44]

Y. Zhang, Z. He, X. Liu, et al., Oral administration of Angelica sinensis polysaccharide protects against pancreatic islets failure in type 2 diabetic mice: pancreatic β-cell apoptosis inhibition, J. Funct. Foods 54 (2019) 361-370. https://doi.org/10.1016/j.jff.2019.01.037.
DOI Google Scholar
[45]

S. Xu, Y. Dou, B. Ye, et al., Ganoderma lucidum polysaccharides improve insulin sensitivity by regulating inflammatory cytokines and gut microbiota composition in mice, J. Funct. Foods 38 (2017) 545-552. https://doi.org/10.1016/j.jff.2017.09.032.
DOI Google Scholar
[46]

A. Sulaimon, O. Tosin, I. Boyenle, et al., AMPK allostery: a therapeutic target for the management/treatment of diabetic nephropathy, Life Sci. 261 (2020) 118455. https://doi.org/10.1016/j.lfs.2020.118455.
DOI Google Scholar
[47]

J. Xu, S. Wang, T. Feng, et al., Hypoglycemic and hypolipidemic effects of total saponins from Stauntonia chinensis in diabetic db/db mice, J. Cell. Mol. Med. 22(12) (2018) 6026-6038. https://doi.org/10.1111/jcmm.13876.
DOI Google Scholar
[48]

T. Szkudelski, K. Szkudelska, The relevance of AMP-activated protein kinase in insulin-secreting β cells: a potential target for improving β cell function, J. Physiol. Biochem. 75(4) (2019) 423-432. https://doi.org/10.1007/s13105-019-00706-3.
DOI Google Scholar
[49]

N. Wang, Z. Ma, C. Chen, et al., Effects of maslinic acid on cardiac function in ischemia-reperfusion injury rats, J. Invest. Med. 70(1) (2021) 20-28. https://doi.org/10.1136/JIM-2021-001927.
DOI Google Scholar
[50]

S. Lu, S. Zhou, J. Chen, et al., Quercetin nanoparticle ameliorates lipopolysaccharide-triggered renal inflammatory impairment by regulation of Sirt1/NF-κB pathway, J. Biomed. Nanotechnol 17(2) (2021) 230-241. https://doi.org/10.1166/JBN.2021.3031.
DOI Google Scholar
[51]

X. Duan, W. Sun, H. Sun, et al., Perfluorooctane sulfonate continual exposure impairs glucose-stimulated insulin secretion via Sirt1-induced upregulation of UCP2 expression, Environ. Pollut. 278 (2021) 116840. https://doi.org/10.1016/J.ENVPOL.2021.116840.
DOI Google Scholar
[52]

A. Mihanfar, M. Akbarzadeh, D. Ghazizadeh, et al., Sirt1: a promising therapeutic target in type 2 diabetes mellitus, Arch. Physiol. Biochem. (2021) 11-16. https://doi.org/10.1080/13813455.2021.1956976.
DOI Google Scholar
[53]

A. Dierendonck, S. Tiphaine, A. Marie-Clotilde, et al., The role of uncoupling protein 2 in macrophages and its impact on obesity-induced adipose tissue inflammation and insulin resistance, J. Biol. Chem. 295(51) (2020) 17535-17548. https://doi.org/10.1074/jbc.ra120.014868.
DOI Google Scholar
[54]

H. Li, D. Chen, W. Sun, et al., KATP opener attenuates diabetic-induced Müller Gliosis and inflammation by modulating Kir6.1 in Microglia, Invest. Ophthalmol. Visual Sci. 62(2) (2021) 3. https://doi.org/10.1167/IOVS.62.2.3.
DOI Google Scholar
[55]

S. Nivedita, E. Michael, L. Kristin, et al., Uncoupling protein 2 regulates daily rhythms of insulin secretion capacity in MIN6 cells and isolated islets from male mice, Mol. Metab. 6(7) (2017) 760-769. https://doi.org/10.1016/j.molmet.2017.04.008.
DOI Google Scholar
[56]

E. Haythorne, M. Rohm, M. Bunt, et al., Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells, Nat. Commun. 10(1) (2019) 1-17. https://doi.org/10.1038/s41467-019-10189-x.
DOI Google Scholar
[57]

G. Rutter, E. Georgiadou, A. Martinez-Sanchez, et al., Metabolic and functional specialisations of the pancreatic beta cell: gene disallowance, mitochondrial metabolism and intercellular connectivity, Diabetologia 63(10) (2020) 1990-1998. https://doi.org/10.1007/s00125-020-05205-5.
DOI Google Scholar
[58]

M. Masini, L. Martino, L. Marselli, et al., Ultrastructural alterations of pancreatic beta cells in human diabetes mellitus, Diabetes/Metab. Res. Rev. 33(6) (2017) e2894. https://doi.org/10.1002/dmrr.2894.
DOI Google Scholar
[59]

N. Sawada, A. Jiang, F. Takizawa, et al., Endothelial PGC-1α mediates vascular dysfunction in diabetes, Cell Metab. 19(2) (2014) 246-258. https://doi.org/10.1016/j.cmet.2013.12.014.
DOI Google Scholar
[60]

X. Wang, H. Gao, W. Wu, et al., The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic β-cells via Sirt1-and PGC-1α-mediated regulation of Glut2, Protein Cell 10(6) (2019) 436-449. https://doi.org/10.1007/s13238-018-0580-1.
DOI Google Scholar
[61]

S. Rius-Pérez, I. Torres-Cuevas, I. Millán, et al., PGC-10, inflammation, and oxidative stress: an integrative view in metabolism, Oxid. Med. Cell. Longevity 2020 (2020). https://doi.org/10.1155/2020/1452696.
DOI Google Scholar
[62]

Y. Zhu, H. Yang, J. Deng, et al., Ginsenoside Rg5 improves insulin resistance and mitochondrial biogenesis of liver via regulation of the Sirt1/PGC-1α signaling pathway in db/db mice, J. Agric. Food Chem. 69(30) (2021) 8428-8439. https://doi.org/10.1021/acs.jafc.1c02476.
DOI Google Scholar
[63]

H. Qian, Y. Li, L. Wang, Vaccinium bracteatum Thunb. leaves’ polysaccharide alleviates hepatic gluconeogenesis via the downregulation of miR-137, Biomed. Pharmacother. 95 (2017) 1397-1403. https://doi.org/10.1016/j.biopha.2017.09.040.
DOI Google Scholar
[64]

R. Zhang, X. Qin, T. Zhang, et al., Astragalus polysaccharide improves insulin sensitivity via AMPK activation in 3T3-L1 adipocytes, Molecules 23(10) (2018) 2711-2711. https://doi.org/10.3390/molecules23102711.
DOI Google Scholar
File
fshw-13-3-1543_ESM.docx (28.2 KB)
Publication history
Copyright
Acknowledgements
Rights and permissions

Publication history

Received: 17 October 2022
Revised: 06 November 2022
Accepted: 11 December 2022
Published: 08 February 2024
Issue date: May 2024

Copyright

© 2024 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press.

Acknowledgements

Acknowledgment

This research was financially supported by the Doctoral Scientific Research Start-up Foundation of the Harbin University of Commerce (2019DS098), the Young Innovation Talents Project from the Harbin University of Commerce (2019CX31), and the Graduate Innovation Fund from the Harbin University of Commerce (YJSCX2019–615HSD). The authors are grateful for their support. The authors also would like to thank BioRender (biorender.com) for flowchart material and potential mechanism figure.

Rights and permissions

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Return