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Food Science and Human Wellness 2024, 13(3): 1410-1421 https://doi.org/10.26599/FSHW.2022.9250119
Research Article | Open Access | Issue | Published: 08 February 2024

Preventive effect of kiwi berry (Actinidia arguta) on loperamide-induced constipation

Show Author's Information Jiyue Zhang,1,,  Bin Li,1,  Ningxuan Gao,  Haikun Li,  Xingyue Cui,  Hanqian Jiang,  Siyi Tang,  Chenyu Jin,  Jinlong Tian( )
College of Food Science, Shenyang Agricultural University, Shenyang 110866, China

1 The authors contributed equally to this article.

Peer review under responsibility of Tsinghua University Press.

Keywords:
Gut microbiota, Constipation, Kiwi berry, VIP-cAMP-PKA-AQP3
Cite this article:
Zhang J, Li B, Gao N, et al. Preventive effect of kiwi berry (Actinidia arguta) on loperamide-induced constipation. Food Science and Human Wellness, 2024, 13(3): 1410-1421. https://doi.org/10.26599/FSHW.2022.9250119
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Abstract Full text About this article

Constipation is a common intestinal disease. Kiwi berries can effectively prevent constipation. However, studies have yet to be done to determine how kiwi berries prevent constipation. For two weeks, mice in this study were continually orally gavaged with kiwi berry, loperamide, or a combination of the 2. This study found that the kiwi group’s feces had more water than the constipated mice. In addition, kiwi berries can speed up gastrointestinal transit (GI), shorten the time it takes to pass the first dark stool, and dramatically enhance body weight gain. In the interstitial cells of Cajal (ICC) cells and colon tissues, alterations in the protein expression of vasoactive intestinal peptide (VIP), cyclic adenosine monophosphate (cAMP), protein kinase A (PKA), and aquaporin-3 (AQP3) were found. At 3, 6, and 12 h of ICC cells and mouse colon, the kiwi group’s VIP, cAMP, PKA, and AQP3 protein expression levels were lower than those of the constipated mice. The kiwi berry can decrease the Firmicutes to Bacteroidetes ratio and boost the diversity and quantity of gut microbiota. By inf luencing the gut microbiota and VIP-cAMP-PKA-AQP3 signaling pathway, kiwi berries prevent constipation.


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About this article

Preventive effect of kiwi berry (Actinidia arguta) on loperamide-induced constipation

Show Author's information Jiyue Zhang,1,, Bin Li,1, Ningxuan Gao, Haikun Li, Xingyue Cui, Hanqian Jiang, Siyi Tang, Chenyu Jin, Jinlong Tian( )
College of Food Science, Shenyang Agricultural University, Shenyang 110866, China

1 The authors contributed equally to this article.

Peer review under responsibility of Tsinghua University Press.

Abstract

Constipation is a common intestinal disease. Kiwi berries can effectively prevent constipation. However, studies have yet to be done to determine how kiwi berries prevent constipation. For two weeks, mice in this study were continually orally gavaged with kiwi berry, loperamide, or a combination of the 2. This study found that the kiwi group’s feces had more water than the constipated mice. In addition, kiwi berries can speed up gastrointestinal transit (GI), shorten the time it takes to pass the first dark stool, and dramatically enhance body weight gain. In the interstitial cells of Cajal (ICC) cells and colon tissues, alterations in the protein expression of vasoactive intestinal peptide (VIP), cyclic adenosine monophosphate (cAMP), protein kinase A (PKA), and aquaporin-3 (AQP3) were found. At 3, 6, and 12 h of ICC cells and mouse colon, the kiwi group’s VIP, cAMP, PKA, and AQP3 protein expression levels were lower than those of the constipated mice. The kiwi berry can decrease the Firmicutes to Bacteroidetes ratio and boost the diversity and quantity of gut microbiota. By inf luencing the gut microbiota and VIP-cAMP-PKA-AQP3 signaling pathway, kiwi berries prevent constipation.

Keywords: Gut microbiota, Constipation, Kiwi berry, VIP-cAMP-PKA-AQP3

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Publication history

Received: 07 September 2022
Revised: 07 October 2022
Accepted: 21 December 2022
Published: 08 February 2024
Issue date: May 2024

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© 2024 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press.

Acknowledgements

This work was financially supported by National Natural Science Foundation of China (U21A20273); China Agriculture Research System of MOF and MARA(CARS-29); the First Batch of Liaoning “Unveiling Leader” Scientific and Technological Projects (2021JH1/10400036).

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