Data-driven analysis of chemicals, proteins and pathways associated with peanut allergy: from molecular networking to biological interpretation

Emmanuel Kemmler; Julian Braun; Florent Fauchère; Sabine Dölle-Bierke; Kirsten Beyer; Robert Preissner; Margitta Worm; Priyanka Banerjee

doi:10.26599/FSHW.2022.9250111

Food Science and Human Wellness 2024, 13(3): 1322-1335 https://doi.org/10.26599/FSHW.2022.9250111

Research Article |

Open Access | Issue | Published: 08 February 2024

Data-driven analysis of chemicals, proteins and pathways associated with peanut allergy: from molecular networking to biological interpretation

Show Author's Information Hide Author's Information Emmanuel Kemmler^{^a^,^b}, Julian Braun^{^b^,^c^,^d}, Florent Fauchère^{^b^,^c^,^d}, Sabine Dölle-Bierke^{^b^,^e}, Kirsten Beyer^{^b^,^f}, Robert Preissner^{^a^,^b}, Margitta Worm^{^b^,^e}, Priyanka Banerjee^{^a^,^b^,}(

)

Institute for Physiology, Charité – University Medicine Berlin, Berlin 10115, Germany

Member of the KFO339, FOOD@, Berlin 10115, Germany

Si-M / “Der Simulierte Mensch” a science framework of Technische Universität Berlin and Charité-Universitätsmedizin Berlin, Berlin 10115, Germany

Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin 10115, Germany

Division of Allergy and Immunology, Department of Dermatology, Venerology and Allergy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 10115, Germany

Pediatrics, Campus Virchow, Charité – University Medicine Berlin, Berlin 10115, Germany

Peer review under responsibility of Tsinghua University Press.

Keywords:

Fatty acids, Data analysis, Food allergy, Allergy informatics, Knowledge-graph, Peroxisome proliferator-activated receptors

Cite this article:

Kemmler E, Braun J, Fauchère F, et al. Data-driven analysis of chemicals, proteins and pathways associated with peanut allergy: from molecular networking to biological interpretation. Food Science and Human Wellness, 2024, 13(3): 1322-1335. https://doi.org/10.26599/FSHW.2022.9250111

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Abstract Full text About this article

Abstract

Peanut allergy is majorly related to severe food induced allergic reactions. Several food including cow’s milk, hen’s eggs, soy, wheat, peanuts, tree nuts (walnuts, hazelnuts, almonds, cashews, pecans and pistachios), f ish and shellf ish are responsible for more than 90% of food allergies. Here, we provide promising insights using a large-scale data-driven analysis, comparing the mechanistic feature and biological relevance of different ingredients presents in peanuts, tree nuts (walnuts, almonds, cashews, pecans and pistachios) and soybean.Additionally, we have analysed the chemical compositions of peanuts in different processed form raw, boiled and dry-roasted. Using the data-driven approach we are able to generate new hypotheses to explain why nuclear receptors like the peroxisome proliferator-activated receptors (PPARs) and its isoform and their interaction with dietary lipids may have signif icant effect on allergic response. The results obtained from this study will direct future experimental and clinical studies to understand the role of dietary lipids and PPAR-isoforms to exert pro-inflammatory or anti-inflammatory functions on cells of the innate immunity and influence antigen presentation to the cells of the adaptive immunity.

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About this article

Data-driven analysis of chemicals, proteins and pathways associated with peanut allergy: from molecular networking to biological interpretation

Show Author's information Hide Author's Information Emmanuel Kemmler^{^a^,^b}, Julian Braun^{^b^,^c^,^d}, Florent Fauchère^{^b^,^c^,^d}, Sabine Dölle-Bierke^{^b^,^e}, Kirsten Beyer^{^b^,^f}, Robert Preissner^{^a^,^b}, Margitta Worm^{^b^,^e}, Priyanka Banerjee^{^a^,^b^,}(

)

Institute for Physiology, Charité – University Medicine Berlin, Berlin 10115, Germany

Member of the KFO339, FOOD@, Berlin 10115, Germany

Si-M / “Der Simulierte Mensch” a science framework of Technische Universität Berlin and Charité-Universitätsmedizin Berlin, Berlin 10115, Germany

Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin 10115, Germany

Pediatrics, Campus Virchow, Charité – University Medicine Berlin, Berlin 10115, Germany

Peer review under responsibility of Tsinghua University Press.

Abstract

Keywords: Fatty acids, Data analysis, Food allergy, Allergy informatics, Knowledge-graph, Peroxisome proliferator-activated receptors

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Received: 22 July 2022

Revised: 06 August 2022

Accepted: 03 September 2022

Published: 08 February 2024

Issue date: May 2024

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).