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Food Science and Human Wellness 2024, 13(1): 370-380 https://doi.org/10.26599/FSHW.2022.9250031
Research Article | Open Access | Issue | Published: 01 June 2023

The interventional effect of Polygonatum cyrtonema Hua polysaccharide on atherosclerosis in mice of different sexes

Show Author's Information Anjun Guoa,b,1,  Xueying Lia,b,1,  Lihua Pana,  Qiangming Lia,  Jianping Luoa,b,  Xueqiang Zhaa,b,c,( )
Engineering Research Centre of Bioprocess of Ministry of Education, Hefei University of Technology, Hefei 230009, China
School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China
Key Laboratory of Metabolism and Regulation for Major Disease of Anhui Higher Education Institutes, Hefei University of Technology, Hefei 230009, China

1These authors contributed equally to this work.

Peer review under responsibility of Tsinghua University Press.

Keywords:
Sex, Polygonatum cyrtonema polysaccharide, Anti-atherosclerosis
Cite this article:
Guo A, Li X, Pan L, et al. The interventional effect of Polygonatum cyrtonema Hua polysaccharide on atherosclerosis in mice of different sexes. Food Science and Human Wellness, 2024, 13(1): 370-380. https://doi.org/10.26599/FSHW.2022.9250031
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Abstract Full text Electronic supplementary material About this article

In the present study, we investigated the intervention effects of a purified Polygonatum cyrtonema polysaccharide (PCP) on high-fat diet (HFD)-induced atherosclerosis in male and female LDLr−/− mice. Results showed that HFD caused severe dyslipidemia, atherosclerotic lesions, oxidative damages and inflammation in male and female mice, and these effects seemed to be more pronounced in males than in females. However, the above variations could be dose-dependently reversed by PCP treatment, and the intervention effects on males were greater than those on females. Nuclear factor kappa-B (NFκB), mitogen-activated protein kinase (MAPKs) and protein kinase B (Akt) are 3 pivotal signaling pathways mediating the development of atherosclerosis. Consistently, PCP was also found to significantly decrease the phosphorylation of p65, p38, extracellular-regulated kinase 1/2 (ERK1/2) and Akt, and increase the protein expression of inhibitor of NF-κB (IκB) in the aortas of male and female mice induced by HFD. Taken together, these findings indicated that PCP could be effective for the prevention of atherosclerosis, and the intervention effect of PCP on male mice was more obvious than that of female mice.


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Electronic supplementary material
About this article

The interventional effect of Polygonatum cyrtonema Hua polysaccharide on atherosclerosis in mice of different sexes

Show Author's information Anjun Guoa,b,1, Xueying Lia,b,1, Lihua Pana, Qiangming Lia, Jianping Luoa,b, Xueqiang Zhaa,b,c,( )
Engineering Research Centre of Bioprocess of Ministry of Education, Hefei University of Technology, Hefei 230009, China
School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China
Key Laboratory of Metabolism and Regulation for Major Disease of Anhui Higher Education Institutes, Hefei University of Technology, Hefei 230009, China

1These authors contributed equally to this work.

Peer review under responsibility of Tsinghua University Press.

Abstract

In the present study, we investigated the intervention effects of a purified Polygonatum cyrtonema polysaccharide (PCP) on high-fat diet (HFD)-induced atherosclerosis in male and female LDLr−/− mice. Results showed that HFD caused severe dyslipidemia, atherosclerotic lesions, oxidative damages and inflammation in male and female mice, and these effects seemed to be more pronounced in males than in females. However, the above variations could be dose-dependently reversed by PCP treatment, and the intervention effects on males were greater than those on females. Nuclear factor kappa-B (NFκB), mitogen-activated protein kinase (MAPKs) and protein kinase B (Akt) are 3 pivotal signaling pathways mediating the development of atherosclerosis. Consistently, PCP was also found to significantly decrease the phosphorylation of p65, p38, extracellular-regulated kinase 1/2 (ERK1/2) and Akt, and increase the protein expression of inhibitor of NF-κB (IκB) in the aortas of male and female mice induced by HFD. Taken together, these findings indicated that PCP could be effective for the prevention of atherosclerosis, and the intervention effect of PCP on male mice was more obvious than that of female mice.

Keywords: Sex, Polygonatum cyrtonema polysaccharide, Anti-atherosclerosis

References(69)

[1]

S.S. Virani, A. Alonso, E.J. Benjamin, et al., Heart disease and stroke statistics-2020 update: a report from the American Heart Association, Circulation 141 (9) (2020) e139-e596. https://doi.org/10.1161/CIR.0000000000000757.
DOI Google Scholar
[2]

I. Cicha, C. Alexiou, Cardiovascular applications of magnetic particles, J. Magn. Magn. Mater. 518 (2020) 167428. https://doi.org/10.1016/j.jmmm.2020.167428.
DOI Google Scholar
[3]

A.O. Jackson, M.A. Regine, C. Subrata, et al., Molecular mechanisms and genetic regulation in atherosclerosis, Int. J. Cardiol. Heart Vasc. 21(2018)36-44. https://doi.org/10.1016/j.ijcha.2018.09.006.
DOI Google Scholar
[4]

X. Bai, X. Wang, Q. Xu, Endothelial damage and stem cell repair in atherosclerosis, Vasc. Pharmacol. 52(5/6) (2010) 224-229. https://doi.org/10.1016/j.vph.2010.02.001.
DOI Google Scholar
[5]

Y.A. Carpentier, R.S. Komsa-Penkova, Clinical Nutrition University. the place of nutrition in the prevention of cardiovascular diseases (CVDs), e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism 6 (2011) e272-e282. https://doi.org/10.1016/j.eclnm.2011.10.002.
DOI Google Scholar
[6]

K. Ueda, N. Fukuma, Y. Adachi, et al., Sex differences and regulatory actions of estrogen in cardiovascular system, Front. Physiol. 12 (2021) 1639. https://doi.org/10.3389/fphys.2021.738218.
DOI Google Scholar
[7]

S. Vallabhajosyula, D. Verghese, V.K. Desai, et al., Sex differences in acute cardiovascular care: a review and needs assessment, Cardiovasc. Res. 118 (3) (2022) 667-685. https://doi.org/10.1093/cvr/cvab063.
DOI Google Scholar
[8]

K.L. McGinigle, S.E. Browder, P.D. Strassle, et al., Sex-related disparities in intervention rates and type of intervention in patients with aortic and peripheral arterial diseases in the National Inpatient Sample Database, J. Vasc. Surg. 73 (6) (2021) 2081-2089. https://doi.org/10.1016/j.jvs.2020.11.034.
DOI Google Scholar
[9]

A. Solanki, L.K. Bhatt, T.P. Johnston, Evolving targets for the treatment of atherosclerosis, Pharmacol. Ther. 187 (2018) 1-12. https://doi.org/10.1016/j.pharmthera.2018.02.002.
DOI Google Scholar
[10]

X. Zhu, Q. Li, F. Lu, et al., Antiatherosclerotic potential of Rhizoma polygonati polysaccharide in hyperlipidemia-induced atherosclerotic hamsters, Drug Res. (Stuttg) 65 (9) (2015) 479-483. https://doi.org/10.1055/s-0034-1387756.
DOI Google Scholar
[11]

J.X. Yang, S. Wu, X.L. Huang, et al., Hypolipidemic activity and antiatherosclerotic effect of polysaccharide of Polygonatum sibiricum in rabbit model and related cellular mechanisms, Evid-Based Compl. Alt. 2015 (2015) 1-6. https://doi.org/10.1155/2015/391065.
DOI Google Scholar
[12]

L. Li, K. Thakur, B.Y. Liao, et al., Antioxidant and antimicrobial potential of polysaccharides sequentially extracted from Polygonatum cyrtonema Hua, Int. J. Biol. Macromol. 114 (2018) 317-323. https://doi.org/10.1016/j.ijbiomac.2018.03.121.
DOI Google Scholar
[13]

Q.X. Gan, X. Wang, M.J. Cao, et al., NF-κB and AMPK-Nrf2 pathways support the protective effect of polysaccharides from Polygonatum cyrtonema Hua in lipopolysaccharide-induced acute lung injury, J. Ethnopharmacol. 291 (2022) 115153. https://doi.org/10.1016/j.jep.2022.115153.
DOI Google Scholar
[14]

J. Liang, R.J. Xu, K. Zong, et al., Structural analysis and anti-obesity effect of Polygonatum cyrtonema polysaccharide against obesity induced by high fat diet in mice, Int. J. Food Sci. Tech. 56 (2021) 4473-4483. https://doi.org/10.1111/ijfs.15208.
DOI Google Scholar
[15]

S.Z. Xie, G. Yang, X.M. Jiang, et al., Polygonatum cyrtonema Hua polysaccharide promotes GLP-1 secretion from enteroendocrine L-cells through sweet taste receptor-mediated cAMP signaling, J. Agric. Food Chem. 68 (25) (2020) 6864-6872. https://doi.org/10.1021/acs.jafc.0c02058.
DOI Google Scholar
[16]

J.C. Defesche, Low-density lipoprotein receptor--its structure, function, and mutations, Semin. Vasc. Med. 4 (1) (2004) 5-11. https://doi.org/10.1016/j.vph.2010.02.001.
DOI Google Scholar
[17]

S. Ishibashi, M.S. Brown, J.L. Goldstein, et al., Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery, J. Clin. Invest. 92 (2) (1993) 883-893. https://doi.org/10.1172/JCI116663.
DOI Google Scholar
[18]

C. Zaragoza, C. Gomez-Guerrero, J.L. Martin-Ventura, et al., Animal models of cardiovascular diseases, J. Biomed. Biotechnol. 2011(2011)497841. https://doi.org/10.1155/2011/497841.
DOI Google Scholar
[19]

S. Ishibashi, J.L. Goldstein, M.S. Brown, et al., Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptornegative mice, J. Clin. Invest. 93 (5) (1994) 1885-1893. https://doi.org/10.1172/JCI117179.
DOI Google Scholar
[20]

W.D. Shen, X.Y. Li, Y.Y. Deng, et al., Polygonatum cyrtonema Hua polysaccharide exhibits anti-fatigue activity via regulating osteocalcin signaling, Int. J. Biol. Macromol. 175 (2021) 235-241. https://doi.org/10.1016/j.ijbiomac.2021.01.200.
DOI Google Scholar
[21]

X.Q. Zha, W.N. Zhang, F.H. Peng, et al., Alleviating VLDL overproduction is an important mechanism for Laminaria japonica polysaccharide to inhibit atherosclerosis in LDLr-/- mice with diet-induced insulin resistance, Mol. Nutr. Food Res. 61 (4) (2017) 1-12. https://doi.org/10.1002/mnfr.201600456.
DOI Google Scholar
[22]

H.L. Zhang, S.H. Cui, X.Q. Zha, et al., Jellyfish skin polysaccharides: extraction and inhibitory activity on macrophage-derived foam cell formation, Carbohyd. Polym. 106 (2014) 393-402. https://doi.org/10.1016/j.carbpol.2014.01.041.
DOI Google Scholar
[23]

F. Li, S.H. Cui, X.Q. Zha, et al., Structure and bioactivity of a polysaccharide extracted from protocorm-like bodies of Dendrobium huoshanense, Int. J. Biol. Macromol. 72 (2015) 664-672. https://doi.org/10.1016/j.ijbiomac.2014.08.026.
DOI Google Scholar
[24]

J. Zhu, W. Liu, J.P. Yu, et al., Characterization and hypoglycemic effect of a polysaccharide extracted from the fruit of Lycium barbarum L, Carbohyd. Polym. 98 (1) (2013) 8-16. https://doi.org/10.1016/j.carbpol.2013.04.057.
DOI Google Scholar
[25]

V. Bhan, R.T. Yan, L.A. Leiter, et al., Relation between obesity and the attainment of optimal blood pressure and lipid targets in high vascular risk outpatients, Am. J. Cardiol. 106 (9) (2010) 1270-1276. https://doi.org/10.1016/j.amjcard.2010.06.055.
DOI Google Scholar
[26]

A.C. Foks, G.H.M.V. Puijvelde, J. Wolbert, et al., CD11b+Gr-1+myeloidderived suppressor cells reduce atherosclerotic lesion development in LDL deficient mice, Cardiovasc. Res. 111 (3) (2016) 252-261. https://doi.org/10.1093/cvr/cvw114.
DOI Google Scholar
[27]

D.E. Venegas-Pino, N. Banko, M.I. Khan, et al., Quantitative analysis and characterization of atherosclerotic lesions in the murine aortic sinus, Jove-J. Vis. Exp. 82 (2013) e50933. https://doi.org/10.3791/50933.
DOI Google Scholar
[28]

U. Forstermann, N. Xia, H. Li, Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis, Circ. Res. 120 (4) (2017) 713-735. https://doi.org/10.1161/CIRCRESAHA.116.309326.
DOI Google Scholar
[29]

J.X. Pan, LncRNA H19 promotes atherosclerosis by regulating MAPK and NF-κB signaling pathway, Eur. Rev. Med. Pharmacol. 21 (2) (2017) 322-328.
Google Scholar
[30]

P. Raggi, J. Genest, J.T. Giles, et al., Role of inflammation in the pathogenesis of atherosclerosis and therapeutic interventions, Atherosclerosis 276 (2018) 98-108. https://doi.org/10.1016/j.atherosclerosis.2018.07.014.
DOI Google Scholar
[31]

J.G. Zhang, Correlation of IL-6 and MDA with carotid atherosclerotic plaque stability, Journal of Clinical Rational Drug Use 11 (2018) 126-127.
Google Scholar
[32]

F. Montecucco, F. Mach, Atherosclerosis is an inflammatory disease, Semin. Immunopathol. 31 (2009) 1-3. https://doi.org/10.1007/s00281-009-0146-7.
DOI Google Scholar
[33]

J.H.F. Rudd, K.S. Myers, S. Bansilal, et al., Relationships among regional arterial inflammation, calcification, risk factors, and biomarkers: a prospective fluorodeoxyglucose positron-emission tomography/computed tomography imaging study, Circ-Caediovasc. Imag. 2 (2) (2009) 107-115. https://doi.org/10.1161/circimaging.108.811752.
DOI Google Scholar
[34]

I.M. Fenyo, A.V. Gafencu, The involvement of the monocytes/macrophages in chronic inflammation associated with atherosclerosis, Immunobiology 218 (11) (2013) 1376-1384. https://doi.org/10.1016/j.imbio.2013.06.005.
DOI Google Scholar
[35]

T. Wu, X.Y. Chen, Y. Wang, et al., Aortic plaque-targeted andrographolide delivery with oxidation-sensitive micelle effectively treats atherosclerosis via simultaneous ROS capture and anti-inflammation, Nanomed-Nanotechnol. (2018) S1549963418304842. https://doi.org/10.1016/j.nano.2018.06.010.
DOI Google Scholar
[36]

J. Geng, C.C. Yang, B.J. Wang, et al., Trimethylamine N-oxide promotes atherosclerosis via CD36-dependent MAPK/JNK pathway, Biomed. Pharmacother. 97 (2018) 941-947. https://doi.org/10.1016/j.biopha.2017.11.016.
DOI Google Scholar
[37]

Y.L. Wu, F. Wang, L.H. Fan, et al., Baicalin alleviates atherosclerosis by relieving oxidative stress and inflammatory responses via inactivating the NF-kappa B and p38 MAPK signaling pathways, Biomed. Pharmacother. 97 (2018) 1673-1679. https://doi.org/10.1016/j.biopha.2017.12.024.
DOI Google Scholar
[38]

A.J. Lusis, Atherosclerosis, Nature 407 (2000) 233-241. https://doi.org/10.1038/35025203.
DOI Google Scholar
[39]

F. Yin, P. Lin, W.Q. Yu, et al., The Cordyceps militaris-derived polysaccharide CM1 alleviates atherosclerosis in LDLR(-/-) mice by improving hyperlipidemia, Front. Mol. Biosci. 13 (2021) 783807. https://doi.org/10.3389/fmolb.2021.783807.
DOI Google Scholar
[40]

D.C. Steinl, B.A. Kaufmann, Ultrasound imaging for risk assessment in atherosclerosis, Int. J. Mol. Sci. 16 (5) (2015) 9749-9769. https://doi.org/10.3390/ijms16059749.
DOI Google Scholar
[41]

P.M. Marcovecchio, G.D. Thomas, Z. Mikulski, et al., Scavenger receptor CD36 directs nonclassical monocyte patrolling along the endothelium during early atherogenesis, Arterioscler. Thromb. Vasc. Biol. 37 (11) (2017) 2043-2052. https://doi.org/10.1161/ATVBAHA.117.309123.
DOI Google Scholar
[42]

A. Ossoli, C. Pavanello, E. Giorgio, et al., Dysfunctional HDL as a therapeutic target for atherosclerosis prevention, Curr. Med. Chem. 26(9)(2019) 1610-1630. https://doi.org/10.2174/0929867325666180316115726.
DOI Google Scholar
[43]

C.Y. Hou, L.L. Chen, L.Z. Yang, et al., An insight into anti-inflammatory effects of natural polysaccharides, Int. J. Biol. Macromol. 153 (2020) 248-255. https://doi.org/10.1016/j.ijbiomac.2020.02.315.
DOI Google Scholar
[44]

K. Kobiyama, K. Ley, Atherosclerosis a chronic inflammatory disease with an autoimmune component, Circ. Res. 123 (10) (2018) 1118-1120. https://doi.org/10.1161/CIRCRESAHA.118.313816.
DOI Google Scholar
[45]

T.V. Popkova, A.V. Starodubova, A.N, Orekhov, Recognition of oxidized lipids by macrophages and its role in atherosclerosis development, Biomedicines 9 (8) (2021) 915. https://doi.org/10.3390/biomedicines9080915.
DOI Google Scholar
[46]

P. Libby, P.M. Ridker, A. Maseri, Inflammation and atherosclerosis, Circulation 105 (9) (2002) 1135-1143. https://doi.org/10.1161/hc0902.104353.
DOI Google Scholar
[47]

G. Tumurkhuu, J. Dagvadorj, R.A. Porritt, et al., Chlamydia pneumoniae hijacks a host autoregulatory IL-1beta loop to drive foam cell formation and accelerate atherosclerosis, Cell Metab. 28 (3) (2018) 432-484. https://doi.org/10.1016/j.cmet.2018.05.027.
DOI Google Scholar
[48]

H. Ohta, H. Wada, T. Niwa, et al., Disruption of tumor necrosis factoralpha gene diminishes the development of atherosclerosis in ApoEdeficient mice, Atherosclerosis 180 (1) (2005) 11-17. https://doi.org/10.1016/j.atherosclerosis.2004.11.016.
DOI Google Scholar
[49]

P. Luo, W. Shi, Y. Wang, et al., Raloxifene inhibits IL-6/STAT3 signaling pathway and protects against high-fat-induced atherosclerosis in ApoE(-/-) mice, Life Sci. 261 (2020) 118304. https://doi.org/118304.10.1016/j.lfs.2020.118304.
DOI Google Scholar
[50]

T. Kitagawa, T. Hattori, K. Sentani, et al., Relationship between interleukin-1beta gene expression in epicardial adipose tissue and coronary atherosclerosis based on computed tomographic analysis, J. Cardiovasc. Comput. Tomogr. 15 (2) (2021) 175-179. https://doi.org/10.1016/j.jcct.2020.06.199.
DOI Google Scholar
[51]

P. Zhang, X. Chen, Y. Zhang, et al., Tet3 enhances IL-6 expression through up-regulation of 5-hmC in IL-6 promoter in chronic hypoxia induced atherosclerosis in offspring rats, Life Sci. 232 (2019) 116601. https://doi.org/10.1016/j.lfs.2019.116601.
DOI Google Scholar
[52]

M.S. Hayden, S. Ghosh, Shared principles in NF-kappaB signaling, Cell 132 (3) (2008) 344-362. https://doi.org/10.1016/j.cell.2008.01.020.
DOI Google Scholar
[53]

J. Zhan, W.Y. Qin, Y. Zhang, et al., Upregulation of neuronal zinc finger protein A20 expression is required for electroacupuncture to attenuate the cerebral inflammatory injury mediated by the nuclear factor-kB signaling pathway in cerebral ischemia/reperfusion rats, J. Neuroinflammation 13(1)(2016) 258. https://doi.org/10.1186/s12974-016-0731-3.
DOI Google Scholar
[54]

Y.L. Wu, F. Wang, L.H. Fan, et al., Baicalin alleviates atherosclerosis by relieving oxidative stress and inflammatory responses via inactivating the NF-κB and p38 MAPK signaling pathways, Biomed. Pharmacother. 97 (2018) 1673-1679. https://doi.org/10.1016/j.biopha.2017.12.024.
DOI Google Scholar
[55]

F. Wan, M.J. Lenardo, The nuclear signaling of NF-kappaB: current knowledge, new insights, and future perspectives, Cell Res. 20 (1) 2010 24-33. https://doi.org/10.1038/cr.2009.137.
DOI Google Scholar
[56]

F. Sigala, P. Savvari, M. Liontos, et al., Increased expression of bFGF is associated with carotid atherosclerotic plaques instability engaging the NF-κB pathway, J. Cell Mol. Med. 14 (9) (2010) 2273-2280. https://doi.org/10.1111/j.1582-4934.2010.01082.x.
DOI Google Scholar
[57]

D. Song, G. Fang, S.Z. Mao, et al., Selective inhibition of endothelial NF-κB signaling attenuates chronic intermittent hypoxia-induced atherosclerosis in mice, Atherosclerosis 270 (2018) 68-75. https://doi.org/10.1016/j.atherosclerosis.2018.01.027.
DOI Google Scholar
[58]

G. Siasos, D. Tousoulis, Z. Siasou, et al., Shear stress, protein kinases and atherosclerosis, Curr. Med. Chem. 14 (14) (2007) 1567-1572. https://doi.org/10.2174/092986707780831087.
DOI Google Scholar
[59]

Y. Yang, Y. Sun, J. Chen, et al., AKT-independent activation of p38 MAP kinase promotes vascular calcification, Redox Biol. 16 (2018) 97-103. https://doi.org/10.1016/j.redox.2018.02.009.
DOI Google Scholar
[60]

X.L. Lu, C.H. Zhao, X.L. Yao, et al., Quercetin attenuates high fructose feeding-induced atherosclerosis by suppressing inflammation and apoptosis via ROS-regulated PI3K/AKT signaling pathway, Biomed. Pharmacother. 85 (2017) 658-671. https://doi.org/10.1016/j.biopha.2016.11.077.
DOI Google Scholar
[61]

M.F. Linton, J.J. Moslehi, V.R. Babaev, Akt signaling in macrophage polarization, survival, and atherosclerosis, Int. J. Mol. Sci. 20 (11) (2019)2703. https://doi.org/10.3390/ijms20112703.
DOI Google Scholar
[62]

K.W. Choi, H.J. Park, D.H. Jung, et al., Inhibition of TNF-α-induced adhesion molecule expression by diosgenin in mouse vascular smooth muscle cells via downregulation of the MAPK, Akt and NF-κB signaling pathways, Vascul. Pharmacol. 53(5/6) (2010) 273-280. https://doi.org/10.1016/j.vph.2010.09.007.
DOI Google Scholar
[63]

T.A. Seimon, Y. Wang, S. Han, et al., Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice, J. Clin. Invest. 119 (4) (2009) 886-898. https://doi.org/10.1172/JCI37262.
DOI Google Scholar
[64]

J.F. Reckelhoff, C. Maric, Sex and gender differences in cardiovascularrenal physiology and pathophysiology, Steroids 75 (11) (2010) 745-746. https://doi.org/10.1016/j.steroids.2010.05.020.
DOI Google Scholar
[65]

K. Ueda, Y. Adachi, P.Y. Liu, et al., Regulatory actions of estrogen receptor signaling in the cardiovascular system, Front. Endocrinol. (Lausanne) 10 (2020) 909. https://doi.org/10.3389/fendo.2019.00909.
DOI Google Scholar
[66]

M. Diaz-Ricart, M. Palomo, B. Fuste, et al., Inhibition of tyrosine kinase activity prevents the adhesive and cohesive properties of platelets and the expression of procoagulant activity in response to collagen, Thromb. Res. 121 (6) (2008) 873-883. https://doi.org/10.1016/j.thromres.2007.08.006.
DOI Google Scholar
[67]

J.E. Raizman, Y.X. Chen, T. Seibert, et al., Heat shock protein-27 attenuates foam cell formation and atherogenesis by down-regulating scavenger receptor-A expression via NF-κB signaling, Biochim. Biophys. Acta. 1831 (12) (2013) 1721-1728. https://doi.org/10.1016/j.bbalip.2013.07.015.
DOI Google Scholar
[68]

H. Chen, M. Hewison, J.S. Adams, Control of estradiol-directed gene transactivation by an intracellular estrogen-binding protein and an estrogen response element-binding protein, Mol. Endocrinol. 22 (3) (2008) 559-569. https://doi.org/10.1210/me.2007-0297.
DOI Google Scholar
[69]

M. Tsuda, M. Iwai, J.M. Li, et al., Inhibitory effects of AT1 receptor blocker, olmesartan, and estrogen on atherosclerosis via anti-oxidative stress, Hypertension 45 (4) (2005) 545-551. https://doi.org/10.1161/01.HYP.0000157409.88971.
DOI Google Scholar
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Received: 08 April 2022
Revised: 12 May 2022
Accepted: 10 July 2022
Published: 01 June 2023
Issue date: January 2024

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© 2024 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press.

Acknowledgements

This study was financially supported by the National Natural Science Foundation of China (32072176; 31271814);the Outstanding Youth Funds of Anhui Province (2208085J31); and the Fundamental Research Funds for the Central Universities (JZ2022HGQA0232; JZ2022HGTA0316).

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