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Perspective | Open Access | Online First

From food to medicine: The coarse grain paradigm shift

Meng-Yao Li1,Yuan-Peng Hao2,Hui-Long Luo3Yan Gao4Jiao Xiao5Qiang Li6Yu-Hang Wang7Hui-Juan Ruan8Yi-Qing Zhu9Bo-Ying Wang10Yu-Long Jia11Xue-Wei Ye12,13Yan Peng14Dian-Zhi Hou15Zhi Yang16He Li17Nan-Qu Huang18Xin Chen19Jing-Wen Xu20Yu Wang21Ke-Jin Zhuang22Shu-Hua Shan23Jiang-Ying Shi23Shi-Fei Li24Zhi-Feng Fang25Ji-Wei Kuang26Wen-Yi Kang27,28 ( )
State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200017, China
Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China
Biomedical Innovation Center, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
Department of Critical Care Medicine, Beijing Hospital, National Center for Gerontology; National Clinical Research Center for Gerontology; The Key Laboratory of Geriatrics of NHC; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China
School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China
Department of Clinical Nutrition, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China
State Key Laboratory for Development and Utilization of Forest Food Resources, Nanjing Forestry University, Nanjing 210037, China
Alpha Health Care Ltd, Auckland, New Zealand 2104
School of liquor and food engineering, Guizhou University, Guiyang 550025, China
Key Laboratory of Artificial Organs and Computational Medicine of Zhejiang Province, Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou 310015, China
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310000, China
Anhui Anti-aging Chinese Herbal Medicine Engineering Research Center, Fuyang Normal University, Fuyang 236037, China
School of Food and Health, Beijing Technology and Business University, Beijing 100048, China
College of Chemistry & Pharmacy, Northwest A & F University, Yangling 712100, China
School of Chemistry and Chemical Engineering, North University of China, Taiyuan 030051, China
National Drug Clinical Trial Institution, Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi 563000, China
Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products, Shanghai 200433, China
College of Food Science & Technology, Shanghai Ocean University, Shanghai 201306, China
Department of Food Nutrition and Safety / National R & D Center for Chinese Herbal Medicine Processing, School of Engineering, China Pharmaceutical University, Nanjing 211198, China
Heilongjiang Bayi Agricultural University, Daqing 163319, China
Institute of Biotechnology, Shanxi University, Taiyuan 030006, China
Institute of Molecular Science, Shanxi University, Taiyuan 030006, China
School of Food Science and Technology, Shihezi University, Shihezi 832003, China
Academy of Agriculture and Forestry Sciences, Qinghai University, Xining 810016, China
National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China
Joint International Research Laboratory of Food & Medicine Resource Function, Henan University, Kaifeng 475004, China

Meng-Yao Li and Yuan-Peng Hao contributed equally to this work.

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Cite this article:
Li M-Y, Hao Y-P, Luo H-L, et al. From food to medicine: The coarse grain paradigm shift. Food & Medicine Homology, 2026, https://doi.org/10.26599/FMH.2026.9420168

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Received: 23 July 2026
Revised: 05 August 2026
Accepted: 05 August 2026
Published: 19 August 2026
© National R & D Center for Edible Fungus Processing Technology 2026. Published by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).