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Perspective | Open Access | Online First

Artificial intelligence-driven paradigms in polysaccharide structure-activity relationships: a new revolution

Shi-Kang Chen1,2,3,4,5,6,†, Tao Li7,†, Qiang Li8, Lei Duan9, Chen Chen10, Zhi Huang11, Yan-Long Cui12, Zhi-Fei Fu13, Xi Chen14, Xiao-Bo Deng2, Ning-Xian Yang15, Fu-Li Yu16, Pei-Lin Chen17, Yan Meng18, Xing-Fang Zhang19, Qiang Ren20, Ren-Peng Du21, Guang-Ping Lü22, Ying-Yue Zhang23, Yu-Ting Su24, Hong-Tao Bi25, Li-Li Guan26, Lei Feng27, Tao Hu28, Hazem Golshany1,2,3,4,5,6, Jia-Lun Duan29( ), Wen-Yi Kang1,2,3,4,5,6 ( )
National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China
College of Agriculture, Henan University, Kaifeng 475004, China
Joint International Research Laboratory of Food & Medicine Resource Function, Kaifeng 475004, China
Functional Food Engineering Technology Research Center, Kaifeng 475004, China
Henan Key University-Enterprise R & D Center for Special Foods, Kaifeng 475004, China
key Laboratory for Innovation and Manufacturing of Specialty Plant Health Foods in Henan Province, Kaifeng 475004, China
Qilin Heheng Network Technology INC, Beijing 100012, China
Department of Critical Care Medicine, Beijing Hospital, National Center for Gerontology; National Clinical Research Center for Gerontology; The Key Laboratory of Geriatrics of NHC; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, China
Department of Civil and Environmental Engineering, Duke University Durham, Durham 27705, USA
Shaanxi Province Key Laboratory of Bio-resources; Qinba Mountain Area Collaborative Innovation Center of Bioresources Comprehensive Development; Qinba State Key Laboratory of Biological Resources and Ecological Environment (Incubation); College of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723001, China
School of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China
College of Food Science, Henan Institute of Science and Technology, Xinxiang 453003, China
National Key Laboratory of Chinese Medicine Modernization, State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
School of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China
School of Public Health, State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang 561113, China
School of Basic Medical Science, Guizhou Medical University, Guiyang 561113, China
College of Oceanology and Food Sciences, Quanzhou Normal University, Quanzhou 362000, China
School of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China
Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
Department of Pharmacy, Jining Medical University, Rizhao 276826, China
College of Heilongjiang Province, School of Life Sciences, Heilongjiang University, Harbin 150000, China
School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, China
School of Life Sciences and Chemical Engineering, Jiangsu Second Normal University, Nanjing 211200, China
School of Food Science, Guangdong Pharmaceutical University, Zhongshan 510006, China
Qinghai Provincial Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation, Northwest Institute of Plateau Biology, Chinese Academy of Science, Xining 810001, China
College of Life Sciences, Engineering Research Center of Bioreactor and Pharmaceutical Development, Ministry of Education, Jilin Agricultural University, Changchun 130118, China
Department of Pharmacy, the First Hospital of China Medical University, Shenyang 110001, China
School of Management Science and Engineering, Guizhou University of Finance and Economics, Guiyang 550025, China
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Jiangsu Provincial Key Laboratory of Functional Substances in Traditional Chinese Medicine Formulae and Innovative Drug Discovery, Nanjing University of Chinese Medicine, Nanjing 210023, China

† Shi-Kang Chen and Tao Li contributed equally to this work.

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Food & Medicine Homology
DOI: 10.26599/FMH.2026.9420165

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Cite this article:
Chen S-K, Li T, Li Q, et al. Artificial intelligence-driven paradigms in polysaccharide structure-activity relationships: a new revolution. Food & Medicine Homology, 2026, https://doi.org/10.26599/FMH.2026.9420165

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Web of Science
Received: 12 July 2026
Revised: 20 July 2026
Accepted: 20 July 2026
Published: 19 August 2026
© National R & D Center for Edible Fungus Processing Technology 2026. Published by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).