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Review Article | Open Access | Online First

Exploration strategies for food and medicine homologous resources: future direction in food development

Zhen-Hua Liu1,2Wen-Jing Guo1,3Xin-Jing Meng1,3Ya-Dan Zhang1,3Yan-Bo Zhao1,3Xu Yang1,2Fu Zhang1Fatma M. El-Demerdash4Wen-Yi Kang1,2,3 ( )
National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China
College of Agriculture, Henan University, Kaifeng 475004, China
Joint International Research Laboratory of Food & Medicine Resource Function, Kaifeng 475004, China
Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Alexandria 21526, Egypt
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Highlights

(1) This paper proposes a strategy for the in-depth exploration of food and medicine homologous resources.

(2) The in-depth exploration of herbs based on herbal classics and folk practices enriched the food and medicine homologous resources.

(3) The exploration of medicinal value in edible resources and the edible value in medicinal resources through the cutting-edge technologies like multimodal omics and AI accelerated the development of food and medicine homologous resources.

Abstract

The theory of food and medicine homology emphasizes the integration of food and medicine functions to achieve health interventions through daily diet, becoming a significant development direction for the health industry. With the rapid advancement of modern disciplines such as mass spectrometry, omics technologies, artificial intelligence (AI), and bioinformatics, the scientific underpinnings of food and medicine homology are gradually being revealed. The in-depth exploration and development of food and medicine homology resources and their products are increasingly shaping the future of food innovation. This paper summarizes the application of classical herbal texts, folk practices, and cutting-edge technologies like AI and multimodal omics technology in mining food and medicine homologous resources. It also highlights the bidirectional value exploration, uncovering medicinal properties in edible resources and the edible potential in medicinal resources, to foster innovative scientific paradigms in this field. This approach accelerates the development of food and medicine homologous resources and paves new pathways for future food innovation.

Graphical Abstract

Based on classical herbal texts and folk practices, this study explores the medicinal value in edible resources and the edible potential in medicinal ones. By integrating multimodal omics and AI technologies, it accelerates the development of food-medicine homologous resources, paving new pathways for future functional food innovation.

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Cite this article:
Liu Z-H, Guo W-J, Meng X-J, et al. Exploration strategies for food and medicine homologous resources: future direction in food development. Food & Medicine Homology, 2026, https://doi.org/10.26599/FMH.2026.9420134

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Received: 26 June 2025
Revised: 06 August 2025
Accepted: 20 August 2025
Published: 10 February 2026
© National R & D Center for Edible Fungus Processing Technology 2026. Published by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).