Highlights
(1) This paper proposes a strategy for the in-depth exploration of food and medicine homologous resources.
(2) The in-depth exploration of herbs based on herbal classics and folk practices enriched the food and medicine homologous resources.
(3) The exploration of medicinal value in edible resources and the edible value in medicinal resources through the cutting-edge technologies like multimodal omics and AI accelerated the development of food and medicine homologous resources.

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