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Opinion | Open Access

Precision application of food and medicine with a multi-omics network and biomimetic delivery system

Qian Zhang1,†, Jing Liu1,†, Jun Li1,†, Meng-Yao Li2( ), Chun-Hui Jin3( )
College of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China
Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Oncology, Shanghai 200127, China
Wuxi Affiliated Hospital, Nanjing University of Chinese Medicine, Wuxi 214071, China

†Qian Zhang, Jing Liu and Jun Li contributed equally to this work.

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Highlights

(1) Proposes a unified framework that couples multi-omics networks with biomimetic delivery for precise microbiota modulation.

(2) Translates Traditional Chinese Medicine syndrome differentiation into reproducible molecular subtypes to guide targeted interventions.

(3) Maps host–microbe–metabolite interactions (e.g., SCFAs, indoles) to identify actionable targets and stratify patients.

(4) Implements adaptive carriers-intestinal-targeted release capsules, probiotic carriers, extracellular vesicle, redox-responsive systems, microbial signal–responsive systems and multi-responsive pH/temperature systems - for site-specific release.

Graphical Abstract

This schematic outlines a pipeline for precision application of food–medicine resources by coupling an Integrated Multi-Omics Interactome with smart delivery. scRNA-seq, spatial transcriptomics, metagenomics and metabolomics translate “syndrome differentiation” into molecular typing, moving from panoramic views to fine resolution. A host–microbiota–metabolite network highlights key mediators (e.g., SCFAs, indoles) to enable efficacy-mechanism validation, subtype/target discovery, and personalized nutrition or prevention. Downstream, biomimetic carriers ensure site-specific action: intestinal-targeted capsules, probiotic carriers, extracellular vesicle–mimetic nanoparticles, and context-aware systems responsive to redox status, microbial signals, or combined pH/temperature cues. Together, discovery informs delivery, yielding safe, targeted, and evidence-based interventions.

References

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Food & Medicine Homology
Volume 3 Issue 1,
March 2026
Article number: 9420129
DOI: 10.26599/FMH.2026.9420129

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Cite this article:
Zhang Q, Liu J, Li J, et al. Precision application of food and medicine with a multi-omics network and biomimetic delivery system. Food & Medicine Homology, 2026, 3(1): 9420129. https://doi.org/10.26599/FMH.2026.9420129

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Web of Science
Received: 14 August 2025
Revised: 23 August 2025
Accepted: 23 August 2025
Published: 28 September 2025
© National R & D Center for Edible Fungus Processing Technology 2026. Published by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).