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Review Article | Open Access

Global policy changes on homologous substances of food and medicine

Xiao-Yu Sun1Xue-Song Xiang2Ya-Jie Zhou3Jing-Yuan Wen4Gui-Ju Sun1 ( )
Department of Nutrition and Food Hygiene, Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China
National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China
Nanjing Zhongke Pharmaceutical Co., Ltd., Nanjing 211102, China
The School of Pharmacy, Faculty of Health Science, University of Auckland, Auckland 1010, New Zealand
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Highlights

(1) Systematically reviews the historical evolution and policy framework of food-medicine substances in China.

(2) Provides a categorized list of Homologous substances of food and medicine, integrating traditional knowledge and modern regulatory needs.

(3) Offers a comparative analysis of food-medicine substance policies in selected countries, broadening the international perspective.

(4) Serves as a valuable reference for policy and practice in the fields of food science, public health, and traditional medicine.

Abstract

Homologous substances of food and medicine (HSFM) are substances that are both food and traditional Chinese medicine (TCM), implementing the TCM concept of “food and medicine homology”. Due to the improvement of people's standard of living and the high demand for improving the quality of life, the usage of HSFM is becoming more and more common, and the legislative issue of HSFM is becoming more and more urgent. HSFM now have a clearer definition and related management policies, which are constantly being improved and updated. However, there is little research to sort out and analysis the current status of management in each country. Therefore, this paper aims to collect the relevant policies that are publicly available in several country and, in particular, elucidates explicitly the historical traceability of HSFM in China, the evolution of the relevant policies, and the catalogue of HSFM that has been updated to date. The data show that the management of HSFM is similar but not identical among different countries, and that there are areas that can be learnt from each other as well as areas that need to be improved. By analysing the policies of different countries, this paper finds that South Korea, Singapore and China have adopted a catalogue for the management of HSFM, which has avoided the current situation of market scrutiny through a clearer catalogue management.It also points out that there is no country that makes health claims on HSFM in terms of policy, which also limits the development of the HSFM industry to a certain extent. A comparison of policies in different countries shows that policymakers can optimise policies to meet consumer demand and stimulate product development in the market by accelerating the addition of substances to the catalogue of HSFM and attempting to make health claims, among other measures.

Graphical Abstract

Overview of homologous substances of food and medicine (HSFM) perspectives in China, Japan, and South Korea, highlighting HSFM origins and policies.

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Food & Medicine Homology
Article number: 9420126

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Cite this article:
Sun X-Y, Xiang X-S, Zhou Y-J, et al. Global policy changes on homologous substances of food and medicine. Food & Medicine Homology, 2026, 3(1): 9420126. https://doi.org/10.26599/FMH.2026.9420126

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Received: 29 October 2024
Revised: 02 December 2024
Accepted: 04 December 2024
Published: 28 September 2025
© National R & D Center for Edible Fungus Processing Technology 2026. Published by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).