Highlights
(1) Systematically reviews the historical evolution and policy framework of food-medicine substances in China.
(2) Provides a categorized list of Homologous substances of food and medicine, integrating traditional knowledge and modern regulatory needs.
(3) Offers a comparative analysis of food-medicine substance policies in selected countries, broadening the international perspective.
(4) Serves as a valuable reference for policy and practice in the fields of food science, public health, and traditional medicine.

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