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Opinion | Open Access

Food and medicine homology components ameliorate metabolic diseases via dual pathways: blood absorption and nonabsorptive pathways

Shu-Yue Zhai1,†, Ling-Ru Li2,†, Jing-Han Jia1, Ya-Xin Cao2, Meng-Yao Li3( ), Yan-Fei Zheng2( ), Wen-Long Sun1( )
School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255000, China
National Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing 100000, China
State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

† Shu-Yue Zhai and Ling-Ru Li contributed equally to this work.

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Highlights

(1) Dual Action Pathways: FMH components treat metabolic diseases via both blood absorption and nonabsorptive pathways.

(2) Integrated Research Method: A novel animal experiment/multi-omics approach systematically analyzes FMH mechanisms, offering a methodological framework.

(3) Multitarget Advantage: FMH components exhibit multicomponent, multitarget, multipathway actions.

(4) Safety & Synergy: Derived from traditional sources, FMH components have favorable safety. Their efficacy stems from synergy between systemic absorption and gut microbiota-mediated effects.

Graphical Abstract

The active components of FMH exert therapeutic effects by entering the bloodstream and interacting with the gut microbiota. Through this dual-pathway mechanism, a standardized methodology can be designed to investigate FMH’s pharmacological actions in metabolic diseases.

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Food & Medicine Homology
Volume 3 Issue 2,
June 2026
Article number: 9420080
DOI: 10.26599/FMH.2026.9420080

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Cite this article:
Zhai S-Y, Li L-R, Jia J-H, et al. Food and medicine homology components ameliorate metabolic diseases via dual pathways: blood absorption and nonabsorptive pathways. Food & Medicine Homology, 2026, 3(2): 9420080. https://doi.org/10.26599/FMH.2026.9420080

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Web of Science
Received: 02 August 2025
Revised: 23 August 2025
Accepted: 24 August 2025
Published: 18 December 2025
© National R & D Center for Edible Fungus Processing Technology 2025. Published by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).