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Review Article | Open Access

Albiflorin: a promising natural monoterpene glycoside with potential therapeutic benefits for multiple physiological systems

Gui-Rong Li1,2,†, Gui-Yang Xia1,3,†, Lin-Nan Zhou1, Huan Xia1, Xiao-Hong Wei1, Peng-Cheng Lin4, Sheng Lin1,4( )
Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 1007040, China
Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China
College of Eco–Environmental Engineering, Qinghai University, Xining 810016, China
College of Pharmaceutical Sciences, Qinghai University for Nationalities, Xining 810000, China

††Gui-Rong Li and Gui-Yang Xia contributed equally to this work.

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Highlights

(1) This review focuses on the pharmacological actions and molecular mechanism of albiflorin (AF), a monoterpene glycoside, in various physiological system diseases.

(2) The pharmacological effects of AF mainly include anti-depressive, anti- neuroprotective, anti-inflammatory, anti-atherosclerotic, antioxidant properties, as well as hepatocyte protective effects.

(3) The aforementioned effects of AF are primarily mediated by its antioxidant activity, modulation of mitochondrial autophagy, regulation of the gut microbiota, and involvement in cell signaling pathways including NF-κB, AMPK, PI3K/Akt, Wnt/β-catenin, among others.

Abstract

Plants of genus Paeonia have both medicinal and edible value for a long history. Albiflorin (AF), one of the characteristic monoterpenoid glycosides of Paeonia L. plants, has extensive protective effects in nervous system, cardiovascular and cerebrovascular system, digestive system, endocrine system, skeletal system, and other diseases. AF has demonstrated favorable outcomes in the treatment of depression, neurodegenerative diseases inflammation, oxidative stress, and other related disorders. The aforementioned effects of AF are primarily mediated by the antioxidant activity, modulation of mitochondrial autophagy, regulation of the gut microbiota, and involvement in cell signaling pathways including NF-κB, AMPK, PI3K/Akt, Wnt/β-catenin, and so on. Based on studies over the past several decades, this review systematically summarizes the pharmacological effects of AF to provide an overall understanding of the pharmacological functions of AF and propose valuable insights for future research of AF on food and medicine applications.

Graphical Abstract

The present review provides a comprehensive review of the pharmacological effects of albiflorin (AF), a monoterpene glycoside, on various systems including the nervous system, cardiovascular and cerebrovascular system, digestive system, immune system and endocrine system.

Keywords

albiflorin (AF)pharmacological effectsmolecular mechanisms

References

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Food & Medicine Homology
Volume 2 Issue 4,
December 2025
Article number: 9420064
DOI: 10.26599/FMH.2025.9420064

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Cite this article:
Li G-R, Xia G-Y, Zhou L-N, et al. Albiflorin: a promising natural monoterpene glycoside with potential therapeutic benefits for multiple physiological systems. Food & Medicine Homology, 2025, 2(4): 9420064. https://doi.org/10.26599/FMH.2025.9420064

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Received: 05 September 2024
Accepted: 05 September 2024
Published: 09 December 2024
© National R & D Center for Edible Fungus Processing Technology 2024. Published by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).