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Review Article | Open Access

The food and medicine homologous Chinese Medicine from Leguminosae species: A comprehensive review on bioactive constituents with neuroprotective effects on nervous system

Xian-Sheng Ye1,2,†, Wen-Jing Tian1,†, Guang-Hui Wang1, Kuan Lin2, Shu-Xiu Zhu3, Yi-Yuan Xia2, Bin-Lian Sun2, Xi-Ji Shu2, Wei Liu2( ), Hai-Feng Chen1( )
Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China
Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China
Department of Traditional Chinese Medicine, School of Medicine, Jianghan University, Wuhan 430056, China

†Xian-Sheng Ye and Wen-Jing Tian contributed equally to this work.

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Highlights

(1) This review summarized the constituents with neuroprotective effects from food and medicine homologous Chinese Medicine in Leguminosae for the first time.

(2) 25 bioactive constituents with neuroprotective effects on nerve system diseases were summarized by searching the PubMed, Science Direct, Web of Science, ACS, Google Scholar, Scopus, and CNKI database.

(3) The neuroprotective effects of constituents exerted through reducing oxidative stress and neuroinflammation responses, protecting nerve cell from apoptosis, and improving mitochondrial function and blood flow to the brain.

Abstract

The food and medicine homologous traditional Chinese medicines (FMHCMs) have attracted great attention for their high nutritional and broad medicinal value, especially for the neuroprotective effects on nervous system. In this review, the neuroprotective constituents of FMHCMs from Leguminosae species, including Astragalus membranaceus (Astragalus membranaceus (Fisch.) Bge.), Glycyrrhiza uralensis Fisch. (Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L.), Cassia obtusifolia L. (Cassia tora L.), Vigna umbellata Ohwi et Ohashi (Vigna angularis Ohwi et Ohashi), Glycine max (L.) Merr., Sophora japonica L., Canavalia gladiata (Jacq.) DC., Pueraria lobata (Willd.) Ohwi, and Dolichos lablab L. are summarized. As a result, 25 bioactive constituents are found to exert neuroprotective effects on nervous system through reducing oxidative stress and neuroinflammation responses, protecting nerve cell from apoptosis, and improving mitochondrial function and blood flow to the brain. The purpose of the review is to provide comprehensively and systematically information about the neuroprotective constituents of FMHCMs from Leguminosae species, and lay the basis for the future developments of FMHCMs from Leguminosae species.

Graphical Abstract

There are 9 kinds of food and medicine homologous traditional Chinese medicines (FMHCMs) from Leguminosae. The neuroprotective constituents of FMHCMs from Leguminosae were summarized, and as a result, 25 bioactive constituents are found to have neuroprotective effects on nerve system diseases, such as Parkinson’s disease, Huntington’s disease, Alzheimer’s disease, ischemia-reperfusion injury, autoimmune encephalomyelitis, subarachnoid hemorrhage, spinal cord injury, sepsis-associated encephalopathy, and diabetic peripheral neuropath. The neuroprotective effects of constituents from Leguminosae were exerted through reducing oxidative stress and neuroinflammation responses, protecting nerve cell from apoptosis, and improving mitochondrial function and blood flow to the brain.

Keywords

neuroprotective effectnervous systemfood and medicine homologous Chinese MedicineLeguminosaebioactive constituents

References

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Food & Medicine Homology
Volume 2 Issue 2,
June 2025
Article number: 9420033
DOI: 10.26599/FMH.2025.9420033

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Cite this article:
Ye X-S, Tian W-J, Wang G-H, et al. The food and medicine homologous Chinese Medicine from Leguminosae species: A comprehensive review on bioactive constituents with neuroprotective effects on nervous system. Food & Medicine Homology, 2025, 2(2): 9420033. https://doi.org/10.26599/FMH.2025.9420033

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Web of Science
Received: 04 July 2024
Revised: 19 July 2024
Accepted: 19 July 2024
Published: 04 September 2024
© National R & D Center for Edible Fungus Processing Technology 2024. Published by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).