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Review Article | Open Access

Protective benefits and mechanisms of Phyllanthus emblica Linn. on aging induced by oxidative stress: a system review

Na Wu1Yao Pan1,2( )Qi Liu1Fereidoon Shahidi3Hong-Yan Li4Fang Chen1Ze-Yuan Deng4Zhi-Hong Zhang1,2( )
School of Public Health, Jiangxi Medical College, Nanchang University, Nanchang 330006, China
Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, Nanchang 330006, China
Department of Biochemistry, Memorial University of Newfoundland, St. John’s A1C 5S7, Canada
State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330000, China
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Highlights

(1) We summarize the nutrients and active constituents in Phyllanthus emblica Linn.

(2) The active components with anti-aging effects in Phyllanthus emblica Linn. are polyphenols, polysaccharides, Vitamin C, SOD and Se.

(3) We point out the shortcomings of the current research, and provide a theoretical basis for the application of Phyllanthus emblica Linn. in drugs and functional foods.

Abstract

This review clarified the nutritional value of Phyllanthus emblica Linn. (PE) and summarized its application prospect as a health food which show anti-aging effects. This review highlighted the latest researches of PE to describe its anti-aging mechanism and related diseases induced by oxidative stress, as well as existing problems and future application directions. In general, PE is a fruit widely consumed in south of Asia, as well as one of the three medicinal plants been selected by the World Health Organization (WHO) for widespread cultivation. Polyphenols (including phenolics, flavonoid, tannins, etc.) are the main bioactive components in PE. Those bioactive compounds show anti-aging effects through scavenging free radicals, preventing mitochondrial damage, anti-triggering lipid peroxidation, and protecting protein structures. The development and research of nutritional foods derived from PE are limited, with most efforts focused on edible fruits and juice beverages. However, there is still significant potential for further high-value utilization of its nutritional properties focus on PE.

Graphical Abstract

By clarifying the nutritional value of Phyllanthus emblica Linn. (PE), it was found that the roots, stems, leaves and fruits of PE were rich in a variety of active substances, such as polyphenols, polysaccharides, SOD, etc. The latest researches of PE have demonstrated that these active substances have many pharmacological effects.

References

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Food & Medicine Homology
Article number: 9420029

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Cite this article:
Wu N, Pan Y, Liu Q, et al. Protective benefits and mechanisms of Phyllanthus emblica Linn. on aging induced by oxidative stress: a system review. Food & Medicine Homology, 2025, 2(2): 9420029. https://doi.org/10.26599/FMH.2025.9420029

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Received: 06 June 2024
Revised: 22 June 2024
Accepted: 23 June 2024
Published: 05 September 2024
© National R & D Center for Edible Fungus Processing Technology 2024. Published by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).