A bibliometric analysis of lipid peroxidation in alcoholic liver disease from 2001 to 2024

Alcoholic liver disease (ALD) is the major liver disease burden among the world, and one of the most significant pathogenesis is lipid peroxidation (LPO), which has been shown to participate in a wide range of diseases. This study aimed to determine the status, research hotspots, and development trend of research on LPO in ALD. Based on the Web of Science Core Collection (WOSCC) and the China National Knowledge Infrastructure (CNKI) databases, the publication and quality of the article, cooperative network, citation, and keyword analysis were described by bibliometric analysis. The number of studies on LPO in ALD fluctuated over time. The largest number of articles was published in Food and Chemical Toxicology. China and USA were the two most published countries, with Zhi-Yun Chen (China) and Petersen DR (USA) being the most prolific researchers. Current research mainly includes the key products and pathway targets in diseases, as well as the exploration of drugs, including traditional chemical and natural drugs. Traditional Chinese medicine plays an important role in preventing and treating ALD. For example, Panax Notoginseng has attracted wide attention from researchers. Among these, the role of 4-hydroxynonenal (4-HNE) in the development of ALD, the relationship between intestinal flora and ALD, and functional foods with antioxidant effects are of great interest. The beneficial effects and targeted therapy of homologous drugs and functional foods in the treatment of ALD should be the trend of future research. This study provides an objective description of LPO in ALD and guidance for future scientific research.