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Review Article | Open Access

Neuron Foundry Mach 8: A Concept of Multi-modal Neuro-supportive Energy Therapy Device for Treating Neurodegenerative Disorders

School of Earth and Environment, Rowan University, NJ 08028 New Jersey, United States
Applied Biotechnology, Faculty of Chemistry, Warsaw University of Technology, 00-661 Warsaw, Poland
Saint Louis University School of Medicine, 2600 Baguio City, Philippines
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Abstract

The prevalence of neurodegenerative disorders is rising as the population ages, and many ailments, such as depression, Parkinson's disease, Alzheimer's disease, autism spectrum disorder, and multiple sclerosis, have intricate underlying mechanisms that are still poorly understood. The Neuron Foundry Mach 8 is a multi-modal neuro-supportive energy therapy device designed to treat neurodegenerative disorders through daily sessions. This device proposes to deliver safe and controlled energy therapy through multiple therapeutic pathways, including stimulating brain mitochondrial energy, supporting homeostasis within the brain's immune system, increasing melatonin production within neuronal mitochondria, and triggering cellular communication through the brain's white matter. By combining these unique energy-based treatments, this device holds promising potential for slowing, stopping, reversing, or at least reducing the effects of neurodegenerative diseases.

Keywords

energy therapymedical devicemulti-modal neuro-supportive energyneurodegenerative disordersNeuron Foundry Mach 8

References

[1]
van Schependom J, D’Haeseleer M. Advances in neurodegenerative diseases. J Clin Med 2023, 12(5): 1709.
Crossref Google Scholar
[2]
Feigin VL, Vos T, Nichols E, et al. The global burden of neurological disorders: translating evidence into policy. Lancet Neurol 2020, 19(3): 255–265.
Crossref Google Scholar
[3]
Durães F, Pinto M, Sousa E. Old drugs as new treatments for neurodegenerative diseases. Pharmaceuticals 2018, 11(2): 44.
Crossref Google Scholar
[4]
Sheikh S, Safia, Haque E, et al. Neurodegenerative diseases: multifactorial conformational diseases and their therapeutic interventions. J Neurodegener Dis 2013, 2013: 563481.
Crossref Google Scholar
[5]
Kern JK, Geier DA, Sykes LK, et al. Evidence of neurodegeneration in autism spectrum disorder. Transl Neurodegener 2013, 2(1): 17.
Crossref Google Scholar
[6]
Khan SA, Khan SA, Narendra AR, et al. Alzheimer’s disease and autistic spectrum disorder: is there any association? CNS Neurol Disord Drug Targets 2016, 15(4): 390–402.
Crossref Google Scholar
[7]
Group TA. ALS untangled No. 20: the deanna protocol. Amyotroph Lateral Scler Frontotemporal Degener 2013, 14(4): 319–323.
Crossref Google Scholar
[8]
Terry W, Robert R. The wahls diet for multiple sclerosis: a clinical conversation with terry wahls, MD, and Robert rountree, MD. Altern Complementary Ther 2017, 23(3): 79–86.
Crossref Google Scholar
[9]
Tan DX, Manchester L, Qin LL, et al. Melatonin: a mitochondrial targeting molecule involving mitochondrial protection and dynamics. Int J Mol Sci 2016, 17(12): 2124.
Crossref Google Scholar
[10]
Nieminen JO, Sinisalo H, Souza VH, et al. Multi-locus transcranial magnetic stimulation system for electronically targeted brain stimulation. Brain Stimul 2022, 15(1): 116–124.
Crossref Google Scholar
[11]
Perkins KL. Cell-attached voltage-clamp and current-clamp recording and stimulation techniques in brain slices. J Neurosci Meth 2006, 154(1/2): 1–18.
Crossref Google Scholar
[12]
Young J, Zoghi M, Khan F, et al. The effect of transcranial direct current stimulation on chronic neuropathic pain in patients with multiple sclerosis: randomized controlled trial. Pain Med 2020, 21(12): 3451–3457.
Crossref Google Scholar
[13]
Jeong H, Im JJ, Park JS, et al. A pilot clinical study of low-intensity transcranial focused ultrasound in Alzheimer’s disease. Ultrasonography 2021, 40(4): 512–519.
Crossref Google Scholar
[14]
G.M. Edelman, Bright air, brilliant fire: On the matter of the mind, Basic Books, New York, NY, US, 1992.
[15]
Grafton ST, de C Hamilton AF. Evidence for a distributed hierarchy of action representation in the brain. Hum Mov Sci 2007, 26(4): 590–616.
Crossref Google Scholar
[16]
Miller BL, Boone K, Cummings JL, et al. Functional correlates of musical and visual ability in frontotemporal dementia. Br J Psychiatry 2000, 176(5): 458–463.
Crossref Google Scholar
[17]
Vickers AJ, Vertosick EA, Lewith G, et al. Acupuncture for chronic pain: update of an individual patient data meta-analysis. J Pain 2018, 19(5): 455–474.
Crossref Google Scholar
[18]
Thrane S, Cohen SM. Effect of Reiki therapy on pain and anxiety in adults: an In-depth literature review of randomized trials with effect size calculations. Pain Manag Nurs 2014, 15(4): 897–908.
Crossref Google Scholar
[19]
Jain S, Mills PJ. Biofield therapies: helpful or full of hype? A best evidence synthesis. Int J Behav Med 2010, 17(1): 1–16.
Crossref Google Scholar
[20]
Amor S, Puentes F, Baker D, et al. Inflammation in neurodegenerative diseases. Immunology 2010, 129(2): 154–169.
Crossref Google Scholar
[21]
Amor S, Peferoen LAN, Vogel DYS, et al. Inflammation in neurodegenerative diseases–an update. Immunology 2014, 142(2): 151–166.
Crossref Google Scholar
[22]
Levin M. Molecular bioelectricity in developmental biology: new tools and recent discoveries. BioEssays 2012, 34(3): 205–217.
Crossref Google Scholar
[23]
Rubik B. The biofield hypothesis: its biophysical basis and role in medicine. J Altern Complementary Med 2002, 8(6): 703–717.
Crossref Google Scholar
[24]
Dotta BT, Buckner CA, Lafrenie RM, et al. Photon emissions from human brain and cell culture exposed to distally rotating magnetic fields shared by separate light-stimulated brains and cells. Brain Res 2011, 1388: 77–88.
Crossref Google Scholar
[25]
Oschman JL. Electricity and magnetism in Diagnosis and therapeutics. In Energy Medicine. Amsterdam: Elsevier, 2016, pp 75–99.
Crossref
[26]
Inglese M, Petracca M. Imaging multiple sclerosis and other neurodegenerative diseases. Prion 2013, 7(1): 47–54.
Crossref Google Scholar
[27]
Silva J, Monge-Fuentes V, Gomes F, et al. Pharmacological alternatives for the treatment of neurodegenerative disorders: wasp and bee venoms and their components as new neuroactive tools. Toxins 2015, 7(8): 3179–3209.
Crossref Google Scholar
[28]
Dhamija R, Saluja A, Goyal V. Multi-modal rehabilitation therapy in Parkinson’s disease and related disorders. Ann Indian Acad Neurol 2023, 26(7): 15.
Crossref Google Scholar
[29]
Bisht B, Darling W, White E, et al. Effects of a multimodal intervention on gait and balance of subjects with progressive multiple sclerosis: a prospective longitudinal pilot study. Degener Neurol Neuromuscul Dis 2017, 7: 79–93.
Crossref Google Scholar
[30]
Adey WR. Biological effects of electromagnetic fields. J Cell Biochem 1993, 51(4): 410–416.
Crossref Google Scholar
[31]
Osellame LD, Blacker TS, Duchen MR. Cellular and molecular mechanisms of mitochondrial function. Best Pract Res Clin Endocrinol Metab 2012, 26(6): 711–723.
Crossref Google Scholar
[32]
Rango M, Bresolin N. Brain mitochondria, aging, and Parkinson’s disease. Genes 2018, 9(5): 250.
Crossref Google Scholar
[33]
Zhou ZQ, Austin G, Young L, et al. Mitochondrial metabolism in major neurological diseases. Cells 2018, 7(12): 229.
Crossref Google Scholar
[34]
Han RR, Liang J, Zhou B. Glucose metabolic dysfunction in neurodegenerative diseases—new mechanistic insights and the potential of hypoxia as a prospective therapy targeting metabolic reprogramming. Int J Mol Sci 2021, 22(11): 5887.
Crossref Google Scholar
[35]
Jensen NJ, Wodschow HZ, Nilsson M, et al. Effects of ketone bodies on brain metabolism and function in neurodegenerative diseases. Int J Mol Sci 2020, 21(22): 8767.
Crossref Google Scholar
[36]
Ailioaie LM, Ailioaie C, Litscher G. Photobiomodulation in Alzheimer’s disease—a complementary method to state-of-the-art pharmaceutical formulations and nanomedicine? Pharmaceutics 2023, 15(3): 916.
Crossref Google Scholar
[37]
Sun WJ, Yan JQ, Wu JN, et al. Efficacy and safety of light therapy as a home treatment for motor and non-motor symptoms of parkinson disease: a meta-analysis. Med Sci Monit 2021, 28: e935074.
Crossref Google Scholar
[38]
Arnold S. Cytochrome c oxidase and its role in neurodegeneration and neuroprotection[M]//Kadenbach B. Mitochondrial Oxidative Phosphorylation. New York: Springer, 2012: 305-339.
Crossref
[39]
Irnich D, Winklmeier S, Beyer A, et al. Electric stimulation acupuncture in peripheral neuropathic pain syndromes. Clinical pilot study on analgesic effectiveness. Schmerz 2002, 16(2): 114–120.
Crossref Google Scholar
[40]
Bachiller S, Jiménez-Ferrer I, Paulus A, et al. Microglia in neurological diseases: a road map to brain-disease dependent-inflammatory response. Front Cell Neurosci 2018, 12: 488.
Crossref Google Scholar
[41]
Machado V, Zöller T, Attaai A, et al. Microglia-mediated neuroinflammation and neurotrophic factor-induced protection in the MPTP mouse model of Parkinson’s disease-lessons from transgenic mice. Int J Mol Sci 2016, 17(2): 151.
Crossref Google Scholar
[42]
Hansen DV, Hanson JE, Sheng M. Microglia in Alzheimer’s disease. J Cell Biol 2018, 217(2): 459–472.
Crossref Google Scholar
[43]
Kraft AD, Harry GJ. Features of microglia and neuroinflammation relevant to environmental exposure and neurotoxicity. Int J Environ Res Public Health 2011, 8(7): 2980–3018.
Crossref Google Scholar
[44]
Geloso MC, Corvino V, Marchese E, et al. The dual role of microglia in ALS: mechanisms and therapeutic approaches. Front Aging Neurosci 2017, 9: 242.
Crossref Google Scholar
[45]
Joers V, Tansey MG, Mulas G, et al. Microglial phenotypes in Parkinson’s disease and animal models of the disease. Prog Neurobiol 2017, 155: 57–75.
Crossref Google Scholar
[46]
Dinetz E. Case series of three neurological side effects in younger-aged individuals after pfizer’s mRNA vaccine. Cureus 2022, 14(4): e23779.
Crossref Google Scholar
[47]
Mandrekar-Colucci S, Landreth GE. Microglia and inflammation in alzheimers disease. CNS Neurol Disord Drug Targets 2010, 9(2): 156–167.
Crossref Google Scholar
[48]
Norris GT, Kipnis J. Immune cells and CNS physiology: Microglia and beyond. J Exp Med 2019, 216(1): 60–70.
Crossref Google Scholar
[49]
Cekici A, Kantarci A, Hasturk H, et al. Inflammatory and immune pathways in the pathogenesis of periodontal disease. Periodontol 2000 2014, 64(1): 57–80.
Crossref Google Scholar
[50]
Braidy N, Alicajic H, Pow D, et al. Potential mechanism of cellular uptake of the excitotoxin quinolinic acid in primary human neurons. Mol Neurobiol 2021, 58(1): 34–54.
Crossref Google Scholar
[51]
Onore C, Careaga M, Ashwood P. The role of immune dysfunction in the pathophysiology of autism. Brain Behav Immun 2012, 26(3): 383–392.
Crossref Google Scholar
[52]
Wang WY, Tan MS, Yu JT, et al. Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease. Ann Transl Med 2015, 3(10): 136.
Google Scholar
[53]
Shao FJ, Wang XY, Wu HJ, et al. Microglia and neuroinflammation: crucial pathological mechanisms in traumatic brain injury-induced neurodegeneration. Front Aging Neurosci 2022, 14: 825086.
Crossref Google Scholar
[54]
Lively S, Schlichter LC. Microglia responses to pro-inflammatory stimuli (LPS, IFNγ+TNFα) and reprogramming by resolving cytokines (IL-4, IL-10). Front Cell Neurosci 2018, 12: 215.
Crossref Google Scholar
[55]
Reiter RJ, Rosales-Corral S, Tan DX, et al. Melatonin as a mitochondria-targeted antioxidant: one of evolution’s best ideas. Cell Mol Life Sci 2017, 74(21): 3863–3881.
Crossref Google Scholar
[56]
Reiter R, Sharma R, Rosales-Corral S, et al. Melatonin and pathological cell interactions: mitochondrial glucose processing in cancer cells. Int J Mol Sci 2021, 22(22): 12494.
Crossref Google Scholar
[57]
Agil A, Reiter RJ, Jiménez-Aranda A, et al. Melatonin ameliorates low-grade inflammation and oxidative stress in young Zucker diabetic fatty rats. J Pineal Res 2013, 54(4): 381–388.
Crossref Google Scholar
[58]
Yeager RL, Oleske DA, Sanders RA, et al. Melatonin as a principal component of red light therapy. Med Hypotheses 2007, 69(2): 372–376.
Crossref Google Scholar
[59]
Fields RD. White matter in learning, cognition and psychiatric disorders. Trends Neurosci 2008, 31(7): 361–370.
Crossref Google Scholar
[60]
Chorghay Z, Káradóttir RT, Ruthazer ES. White matter plasticity keeps the brain in tune: axons conduct while Glia wrap. Front Cell Neurosci 2018, 12: 428.
Crossref Google Scholar
[61]
Syková E, Nicholson C. Diffusion in brain extracellular space. Physiol Rev 2008, 88(4): 1277–1340.
Crossref Google Scholar
[62]
ALSUntangled Group, Fournier C, Bedlack B, et al. ALS Untangled No. 20: the Deanna protocol. Amyotroph Lateral Scler Frontotemporal Degener 2013, 14(4):319-23.
Crossref Google Scholar
[63]
Dong DY, Zielke HR, Yeh D, et al. Cellular stress and apoptosis contribute to the pathogenesis of autism spectrum disorder. Autism Res 2018, 11(7): 1076–1090.
Crossref Google Scholar
[64]
Gorman AM. Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling. J Cellular Molecular Medi 2008, 12(6a): 2263–2280.
Crossref Google Scholar
[65]
Majd S, Power JH, Grantham HJM. Neuronal response in Alzheimer’s and Parkinson’s disease: the effect of toxic proteins on intracellular pathways. BMC Neurosci 2015, 16(1): 69.
Crossref Google Scholar
[66]
Pagano G, Pallardó FV, Lyakhovich A, et al. Aging-related disorders and mitochondrial dysfunction: a critical review for prospect mitoprotective strategies based on mitochondrial nutrient mixtures. Int J Mol Sci 2020, 21(19): 7060.
Crossref Google Scholar
[67]
Shaffer J. Neuroplasticity and clinical practice: building brain power for health. Front Psychol 2016, 7: 1118.
Crossref Google Scholar
[68]
Kolb B, Gibb R. Brain plasticity and behaviour in the developing brain. J Can Acad Child Adolesc Psychiatry 2011, 20(4): 265–276.
Google Scholar
[69]
Rusu SI, Pennartz CMA. Learning, memory and consolidation mechanisms for behavioral control in hierarchically organized cortico-basal Ganglia systems. Hippocampus 2020, 30(1): 73–98.
Crossref Google Scholar
[70]
Dickerson BC, Eichenbaum H. The episodic memory system: neurocircuitry and disorders. Neuropsychopharmacology 2010, 35(1): 86–104.
Crossref Google Scholar
[71]
R Hamblin M. Mechanisms and applications of the anti-inflammatory effects of photobiomodulation. AIMS Biophys 2017, 4(3): 337–361.
Crossref Google Scholar
[72]
Kahraman N, Yümün G, Demir D, et al. Detection of residual varicose veins with near infrared light in the early period after varicose surgery and near infrared light assisted sclerotherapy. Vascular 2022, 30(6): 1174–1181.
Crossref Google Scholar
[73]
Hamblin MR. Could photobiomodulation treat autism spectrum disorder? Photobiomodulation Photomed Laser Surg 2022, 40(6): 367–369.
Crossref Google Scholar
[74]
Johnstone DM, Moro C, Stone J, et al. Turning on lights to stop neurodegeneration: the potential of near infrared light therapy in Alzheimer’s and Parkinson’s disease. Front Neurosci 2016, 9: 500.
Crossref Google Scholar
[75]
Rojas JC, Bruchey AK, Gonzalez-Lima F. Low-level light therapy improves cortical metabolic capacity and memory retention. J Alzheimers Dis 2012, 32(3): 741–752.
Crossref Google Scholar
[76]
Stepanov YV, Golovynska I, Zhang RL, et al. Near-infrared light reduces β-amyloid-stimulated microglial toxicity and enhances survival of neurons: mechanisms of light therapy for Alzheimer’s disease. Alzheimers Res Ther 2022, 14(1): 84.
Crossref Google Scholar
[77]
Akimoto K, Hu AL, Yamaguchi T, et al. Effect of 528 hz music on the endocrine system and autonomic nervous system. Health 2018, 10(9): 1159–1170.
Crossref Google Scholar
[78]
Kumar M, Abhayapala TD, Samarasinghe P. A preliminary investigation on frequency dependant cues for human emotions. Acoustics 2022, 4(2): 460–468.
Crossref Google Scholar
[79]
Sagol AD. Music Theory: 432 Hz Tuning - Separating Fact From Fiction. 2016. Available at: https://ask.audio/articles/music-theory-432-hz-tuning-separating-fact-from-fiction (accessed 1 Nov 2023).
[80]
Babayi Daylari T, Riazi GH, Pooyan S, et al. Influence of various intensities of 528Hz sound-wave in production of testosterone in rat’s brain and analysis of behavioral changes. Genes Genom 2019, 41(2): 201–211.
Crossref Google Scholar
[81]
Ross B, Lopez MD. 40-Hz Binaural beats enhance training to mitigate the attentional blink. Sci Rep 2020, 10: 7002.
Crossref Google Scholar
[82]
Jirakittayakorn N, Wongsawat Y. Brain responses to 40-Hz binaural beat and effects on emotion and memory. Int J Psychophysiol 2017, 120: 96–107.
Crossref Google Scholar
[83]
Meditationalstate, Scientists CAN’T Explain Why This Audio HEALS People! 111Hz • Binaural Beats. 2023. Available at: https://meditationalstate.com/product/scientists-cant-explain-why-this-audio-heals-people-111hz-binaural-beats/ (accessed 1 Nov 2023).
[84]
Zhang YQ, Zhang ZY, Luo L, et al. 40 hz light flicker alters human brain electroencephalography microstates and complexity implicated in brain diseases. Front Neurosci 2021, 15: 777183.
Crossref Google Scholar
[85]
Ismail R, Hansen AK, Parbo P, et al. The effect of 40-hz light therapy on amyloid load in patients with prodromal and clinical Alzheimer’s disease. Int J Alzheimers Dis 2018, 2018: 6852303.
Crossref Google Scholar
[86]
Wu CY, Yang LM, Feng S, et al. Therapeutic non-invasive brain treatments in Alzheimer’s disease: recent advances and challenges. Inflamm Regen 2022, 42(1): 1–32.
Crossref Google Scholar
[87]
Curtis D, Fallows S, Morris M, et al. The efficacy of frequency specific microcurrent therapy on delayed onset muscle soreness. J Bodyw Mov Ther 2010, 14(3): 272–279.
Crossref Google Scholar
[88]
McMakin CR, Oschman JL. Visceral and somatic disorders: tissue softening with frequency-specific microcurrent. J Altern Complementary Med 2013, 19(2): 170–177.
Crossref Google Scholar
[89]
Vincent A, Whipple MO, Low PA, et al. Patients with fibromyalgia have significant autonomic symptoms but modest autonomic dysfunction. PM&R 2016, 8(5): 425–435.
Crossref Google Scholar
[90]
Ravazzani P, Ruohonen J, Grandori F, et al. Magnetic stimulation of the nervous system: induced electric field in unbounded, semi-infinite, spherical, and cylindrical media. Ann Biomed Eng 1996, 24(5): 606–616.
Crossref Google Scholar
[91]
Trofè A, Piras A, Muehsam D, et al. Effect of pulsed electromagnetic fields (PEMFs) on muscular activation during cycling: a single-blind controlled pilot study. Healthcare 2023, 11(6): 922.
Crossref Google Scholar
[92]
Ross CL, Zhou Y, McCall CE, et al. The use of pulsed electromagnetic field to modulate inflammation and improve tissue regeneration: a review. Bioelectricity 2019, 1(4): 247–259.
Crossref Google Scholar
[93]
Harman J, Hill T, Treating Autism Spectrum Disorder Using Pulsed EMF Therapy: A Case Series Report, Asia Pacific Journal of Neurotherapy 2019, 1: 21–26.
Google Scholar
[94]
Kantor J, Campbell EA, Kantorová L, et al. Exploring vibroacoustic therapy in adults experiencing pain: a scoping review. BMJ Open 2022, 12(4): e046591.
Crossref Google Scholar
[95]
Bartel L, Mosabbir A. Possible mechanisms for the effects of sound vibration on human health. Healthcare 2021, 9(5): 597.
Crossref Google Scholar
[96]
Yang LD, Youngblood H, Wu CY, et al. Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation. Transl Neurodegener 2020, 9(1): 19.
Crossref Google Scholar
[97]
Bertram L. The genetic epidemiology of neurodegenerative disease. J Clin Investig 2005, 115(6): 1449–1457.
Crossref Google Scholar
[98]
Bohr N. the atomic theory and the fundamental principles underlying the description of nature. In Niels Bohr Collected Works. Amsterdam: Elsevier, 1985, pp 219–253.
Crossref
[99]
Swerdlow RH, Burns JM, Khan SM. The Alzheimer’s disease mitochondrial cascade hypothesis. J Alzheimers Dis 2010, 20(Suppl 2): S265–S279.
Crossref Google Scholar
[100]
Nicholls DJ, Ferguson, SJ. Bioenergetics, 3rd edn. Academic Press, London, 2002.
Crossref
[101]
Zhang JX, Wang XL, Vikash V, et al. ROS and ROS-mediated cellular signaling. Oxid Med Cell Longev 2016, 2016: 4350965.
Crossref Google Scholar
[102]
IBM-Corp, IBM SPSS Statistics, IBM Corp, Armonk, NY, 2019.
[103]
Origin(Pro), OriginLab, OriginLab Corporation, Northampton, MA, USA, 2021.
[104]
Schiffer F, Johnston AL, Ravichandran C, et al. Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety. Behav Brain Funct 2009, 5(1): 46.
Crossref Google Scholar
[105]
Ancoli-Israel S, Martin JL, Gehrman P, et al. Effect of light on agitation in institutionalized patients with severe alzheimer disease. Am J Geriatr Psychiatry 2003, 11(2): 194–203.
Crossref Google Scholar
[106]
Fontana Gasio P. Dawn–dusk simulation light therapy of disturbed circadian rest–activity cycles in demented elderly. Exp Gerontol 2003, 38(1/2): 207–216.
Crossref Google Scholar
[107]
Arroyo-Anlló EM, Dauphin S, Fargeau MN, et al. Music and emotion in Alzheimer’s disease. Alzheimers Res Ther 2019, 11(1): 69.
Crossref Google Scholar
[108]
Calomeni MR, Furtado da Silva V, Velasques BB, et al. Modulatory effect of association of brain stimulation by light and binaural beats in specific brain waves. Clin Pract Epidemiol Ment Health 2017, 13(1): 134–144.
Crossref Google Scholar
[109]
Sharpe RLS, Mahmud M, Kaiser MS, et al. Gamma entrainment frequency affects mood, memory and cognition: an exploratory pilot study. Brain Inform 2020, 7(1): 17.
Crossref Google Scholar
[110]
Agger MP, Danielsen ER, Carstensen MS, et al. Safety, feasibility, and potential clinical efficacy of 40 Hz invisible spectral flicker versus placebo in patients with mild-to-moderate Alzheimer’s disease: a randomized, placebo-controlled, double-blinded, pilot study. J Alzheimers Dis 2023, 92(2): 653–665.
Crossref Google Scholar
[111]
Cimenser A, Hempel E, Travers T, et al. Sensory-evoked 40-hz gamma oscillation improves sleep and daily living activities in Alzheimer’s disease patients. Front Syst Neurosci 2021, 15: 746859.
Crossref Google Scholar
[112]
He QL, Colon-Motas KM, Pybus AF, et al. A feasibility trial of gamma sensory flicker for patients with prodromal Alzheimer’s disease. A&D Transl Res & Clin Interv 2021, 7(1): e12178.
Crossref Google Scholar
[113]
Kim YJ, Kim HR, Jung YH, et al. Effects of electrical automatic massage on cognition and sleep quality in Alzheimer’s disease spectrum patients: a randomized controlled trial. Yonsei Med J 2021, 62(8): 717.
Crossref Google Scholar
[114]
Satoh S, Kajiwara M, Kiyokawa E, et al. Rivastigmine patch and massage for Alzheimer’s disease patients. Geriatrics Gerontology Int 2013, 13(2): 515–516.
Crossref Google Scholar
[115]
Videnovic A, Klerman EB, Wang W, et al. Timed light therapy for sleep and daytime sleepiness associated with parkinson disease. JAMA Neurol 2017, 74(4): 411.
Crossref Google Scholar
[116]
Liebert A, Bicknell B, Laakso EL, et al. Improvements in clinical signs of Parkinson’s disease using photobiomodulation: a prospective proof-of-concept study. BMC Neurol 2021, 21(1): 256.
Crossref Google Scholar
[117]
Calvano A, Timmermann L, Loehrer PA, et al. Binaural acoustic stimulation in patients with Parkinson’s disease. Front Neurol 2023, 14: 1167006.
Crossref Google Scholar
[118]
González D, Bruña R, Martínez-Castrillo JC, et al. First longitudinal study using binaural beats on parkinson disease. Int J Neur Syst 2023, 33(6): 2350027.
Crossref Google Scholar
[119]
Gálvez G, Recuero M, Canuet L, et al. Short-term effects of binaural beats on EEG power, functional connectivity, cognition, gait and anxiety in Parkinson’s disease. Int J Neural Syst 2018, 28(5): 1750055.
Crossref Google Scholar
[120]
Zarkali A, Lees AJ, Weil RS. Flickering stimuli do not reliably induce visual hallucinations in Parkinson’s disease. J Park Dis 2019, 9(3): 631–635.
Crossref Google Scholar
[121]
Morberg BM, Malling AS, Jensen BR, et al. Effects of transcranial pulsed electromagnetic field stimulation on quality of life in Parkinson’s disease. Euro J Neurology 2018, 25(7): 963.
Crossref Google Scholar
[122]
Jensen BR, Malling ASB, Schmidt SI, et al. Long-term treatment with transcranial pulsed electromagnetic fields improves movement speed and elevates cerebrospinal erythropoietin in Parkinson’s disease. PLoS One 2021, 16(4): e0248800.
Crossref Google Scholar
[123]
Morberg BM, Malling AS, Jensen BR, et al. Parkinson’s disease and transcranial pulsed electromagnetic fields: a randomized clinical trial. Mov Disord 2017, 32(4): 625–626.
Crossref Google Scholar
[124]
Malling ASB, Morberg BM, Wermuth L, et al. Effect of transcranial pulsed electromagnetic fields (T-PEMF) on functional rate of force development and movement speed in persons with Parkinson’s disease: a randomized clinical trial. PLoS One 2018, 13(9): e0204478.
Crossref Google Scholar
[125]
Morberg BM, Malling AS, Jensen BR, et al. The Hawthorne effect as a pre-placebo expectation in Parkinsons disease patients participating in a randomized placebo-controlled clinical study. Nord J Psychiatry 2018, 72(6): 442–446.
Crossref Google Scholar
[126]
Khedr EM, Farweez HM, Islam H. Therapeutic effect of repetitive transcranial magnetic stimulation on motor function in Parkinson’s disease patients. Euro J Neurology 2003, 10(5): 567–572.
Crossref Google Scholar
[127]
Mancini M, Smulders K, Harker G, et al. Assessment of the ability of open- and closed-loop cueing to improve turning and freezing in people with Parkinson’s disease. Sci Rep 2018, 8: 12773.
Crossref Google Scholar
[128]
Klaver EC, van Vugt JPP, Bloem BR, et al. Good vibrations: tactile cueing for freezing of gait in Parkinson’s disease. J Neurol 2023, 270(7): 3424–3432.
Crossref Google Scholar
[129]
Donoyama N, Ohkoshi N. Effects of traditional Japanese massage therapy on various symptoms in patients with Parkinson’s disease: a case-series study. J Altern Complementary Med 2012, 18(3): 294–299.
Crossref Google Scholar
[130]
Törnhage CJ, Skogar Ö, Borg A, et al. Short- and long-term effects of tactile massage on salivary cortisol concentrations in Parkinson’s disease: a randomised controlled pilot study. BMC Complementary Altern Med 2013, 13(1): 357.
Crossref Google Scholar
[131]
Paterson C, A Allen J, Browning M, et al. A pilot study of therapeutic massage for people with Parkinson’s disease: the added value of user involvement. Complementary Ther Clin Pract 2005, 11(3): 161–171.
Crossref Google Scholar
[132]
Craig LH, Svircev A, Haber M, et al. Controlled pilot study of the effects of neuromuscular therapy in patients with Parkinson’s disease. Mov Disord 2006, 21(12): 2127–2133.
Crossref Google Scholar
[133]
Mateen FJ, Vogel AC, Kaplan TB, et al. Light therapy for multiple sclerosis-associated fatigue: a randomized, controlled phase II trial. J Neurol 2020, 267(8): 2319–2327.
Crossref Google Scholar
[134]
Voggenberger L, Böck M, Moser D, et al. Bright light therapy as a non-pharmacological treatment option for multiple sclerosis-related fatigue: a randomized sham-controlled trial. Mult Scler J Exp Transl Clin 2022, 8(4): 20552173221133262.
Crossref Google Scholar
[135]
Shetty GM, Rawat P, Sharma A. Effect of adjuvant frequency-specific microcurrents on pain and disability in patients treated with physical rehabilitation for neck and low back pain. J Bodyw Mov Ther 2020, 24(4): 168–175.
Crossref Google Scholar
[136]
Granja-Domínguez A, Hochsprung A, Luque-Moreno C, et al. Effects of pulsed electromagnetic field therapy on fatigue, walking performance, depression, and quality of life in adults with multiple sclerosis: a randomized placebo-controlled trial. Braz J Phys Ther 2022, 26(5): 100449.
Crossref Google Scholar
[137]
Hochsprung A, Escudero-Uribe S, Ibáñez-Vera AJ, et al. Effectiveness of monopolar dielectric transmission of pulsed electromagnetic fields for multiple sclerosis–related pain: a pilot study. Neurol Engl Ed 2021, 36(6): 433–439.
Crossref Google Scholar
[138]
Mostert S, Kesselring J. Effect of pulsed magnetic field therapy on the level of fatigue in patients with multiple sclerosis - a randomized controlled trial. Mult Scler 2005, 11(3): 302–305.
Crossref Google Scholar
[139]
Haase R, Piatkowski J, Ziemssen T. Long-term effects of Bio-Electromagnetic-Energy Regulation therapy on fatigue in patients with multiple sclerosis. Altern Ther Health Med 2011, 17(6): 22–28.
Google Scholar
[140]
Negahban H, Rezaie S, Goharpey S. Massage therapy and exercise therapy in patients with multiple sclerosis: a randomized controlled pilot study. Clin Rehabil 2013, 27(12): 1126–1136.
Crossref Google Scholar
[141]
McClurg D, Goodman K, Hagen S, et al. Abdominal massage for neurogenic bowel dysfunction in people with multiple sclerosis (AMBER - Abdominal Massage for Bowel Dysfunction Effectiveness Research): study protocol for a randomised controlled trial. Trials 2017, 18(1): 150.
Crossref Google Scholar
[142]
Lee JE, Bisht B, Hall MJ, et al. A multimodal, nonpharmacologic intervention improves mood and cognitive function in people with multiple sclerosis. J Am Coll Nutr 2017, 36(3): 150–168.
Crossref Google Scholar
[143]
Bisht B, Darling WG, Grossmann RE, et al. A multimodal intervention for patients with secondary progressive multiple sclerosis: feasibility and effect on fatigue. J Altern Complementary Med 2014, 20(5): 347–355.
Crossref Google Scholar
[144]
Siev-Ner I, Gamus D, Lerner-Geva L, et al. Refiexology treatment relieves symptoms of multiple sclerosis: a randomized controlled study. Mult Scler 2003, 9(4): 356–361.
Crossref Google Scholar
[145]
Hughes CM, Smyth S, Lowe-Strong AS. Reflexology for the treatment of pain in people with multiple sclerosis: a double-blind randomised sham-controlled clinical trial. Mult Scler 2009, 15(11): 1329–1338.
Crossref Google Scholar
[146]
van Maanen A, Meijer AM, Smits MG, et al. Classical conditioning for preserving the effects of short melatonin treatment in children with delayed sleep: a pilot study. Nat Sci Sleep 2017, 9: 67–79.
Crossref Google Scholar
[147]
Shi S., Wang J., Wang Y, et al. Effects of different types of visual music on the prefrontal hemodynamics of children with autism spectrum disorder based on functional near-infrared spectroscopy, Translational pediatrics 2023, 12(2): 162–171.
Crossref Google Scholar
[148]
Leisman G, Machado C, Machado Y, et al. Effects of low-level laser therapy in autism spectrum disorder. In Advances in Experimental Medicine and Biology. Cham: Springer International Publishing, 2018, pp 111–130.
Crossref
[149]
Carrick FR, Pagnacco G, Hankir A, et al. The treatment of autism spectrum disorder with auditory neurofeedback: a randomized placebo controlled trial using the mente autism device. Front Neurol 2018, 9: 537.
Crossref Google Scholar
[150]
Johnston D, Egermann H, Kearney G. The use of binaural based spatial audio in the reduction of auditory hypersensitivity in autistic young people. Int J Environ Res Public Health 2022, 19(19): 12474.
Crossref Google Scholar
[151]
Darwish ME, El-Beshlawy HW, Ramadan ES, et al. Study of the role of the transcranial magnetic stimulation on language progress in autism spectrum disorder. Egypt J Otolaryngol 2021, 37(1): 59.
Crossref Google Scholar
[152]
Lu WP, Tsai WH, Lin LY, et al. The beneficial effects of massage on motor development and sensory processing in young children with developmental delay: a randomized control trial study. Dev Neurorehabilit 2019, 22(7): 487–495.
Crossref Google Scholar
[153]
Piravej K, Tangtrongchitr P, Chandarasiri P, et al. Effects of Thai traditional massage on autistic children’s behavior. J Altern Complementary Med 2009, 15(12): 1355–1361.
Crossref Google Scholar
[154]
Silva LMT, Cignolini A, Warren R, et al. Improvement in sensory impairment and social interaction in young children with autism following treatment with an original Qigong massage methodology. Am J Chin Med 2007, 35(3): 393–406.
Crossref Google Scholar
[155]
Trivedi JK. Cognitive deficits in psychiatric disorders: current status. Indian J Psychiatry 2006, 48(1): 10.
Crossref Google Scholar
[156]
Petzinger GM, Fisher BE, McEwen S, et al. Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson’s disease. Lancet Neurol 2013, 12(7): 716–726.
Crossref Google Scholar
[157]
Sharew NT. The effect of multimodal non-pharmacological interventions on cognitive function improvement for people with dementia: a systematic review. Front Public Health 2022, 10: 894930.
Crossref Google Scholar
[158]
Pagonabarraga J, Álamo C, Castellanos M, et al. Depression in major neurodegenerative diseases and strokes: a critical review of similarities and differences among neurological disorders. Brain Sci 2023, 13(2): 318.
Crossref Google Scholar
[159]
Ray Chaudhuri K, Rojo JM, Schapira AHV, et al. A proposal for a comprehensive grading of Parkinson’s disease severity combining motor and non-motor assessments: meeting an unmet need. PLoS One 2013, 8(2): e57221.
Crossref Google Scholar
[160]
Lord C, Brugha TS, Charman T, et al. Autism spectrum disorder. Nat Rev Dis Primers 2020, 6: 5.
Crossref Google Scholar
[161]
Chalah MA, Riachi N, Ahdab R, et al. Fatigue in multiple sclerosis: neural correlates and the role of non-invasive brain stimulation. Front Cell Neurosci 2015, 9: 460.
Crossref Google Scholar
[162]
Saniotis A, Henneberg M, Sawalma AR. Integration of nanobots into neural circuits As a future therapy for treating neurodegenerative disorders. Front Neurosci 2018, 12: 153.
Crossref Google Scholar
[163]
Kaub L, Schmitz C. More than ninety percent of the light energy emitted by near-infrared laser therapy devices used to treat musculoskeletal disorders is absorbed within the first ten millimeters of biological tissue. Biomedicines 2022, 10(12): 3204.
Crossref Google Scholar
[164]
Cunnane SC, Trushina E, Morland C, et al. Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing. Nat Rev Drug Discov 2020, 19(9): 609–633.
Crossref Google Scholar
Brain Science Advances
Volume 10 Issue 1,
March 2024
Pages 5-37
DOI: 10.26599/BSA.2023.9050026
Cite this article:
McGlynn C, Dermawan D, Canonizado GM. Neuron Foundry Mach 8: A Concept of Multi-modal Neuro-supportive Energy Therapy Device for Treating Neurodegenerative Disorders. Brain Science Advances, 2024, 10(1): 5-37. https://doi.org/10.26599/BSA.2023.9050026

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Received: 19 November 2023
Revised: 09 December 2023
Accepted: 14 December 2023
Published: 05 March 2024
© The authors 2023.

This article is published with open access at journals.sagepub.com/home/BSA

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