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Brain Science Advances 2023, 9(4): 275-282 https://doi.org/10.26599/BSA.2023.9050006
Research Article | Open Access | Issue | Published: 05 December 2023

High amplitude high frequency oscillations during posttraumatic epileptogenesis

Show Author's Information Jagannathan Rangarajan,  Udaya Kumar( )
Department of Neurology, University of California Los Angeles, Los Angeles 90024, California, U.S.A.
Keywords:
epilepsy, biomarker, traumatic brain injury, high frequency oscillations
Cite this article:
Rangarajan J, Kumar U. High amplitude high frequency oscillations during posttraumatic epileptogenesis. Brain Science Advances, 2023, 9(4): 275-282. https://doi.org/10.26599/BSA.2023.9050006
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Abstract Full text About this article
Background:

The aim of the present study was to investigate if high amplitude high frequency oscillations (haHFOs) could be a biomarker of posttraumatic epileptogenesis.

Methods:

After an initial craniotomy of rats and inducement of traumatic brain injury (TBI) through a fluid percussion, recording microelectrodes were implanted bilaterally in different brain areas. Wideband brain electrical activity was recorded intermittently from Day 1 of TBI and continued till week 21. HaHFO analysis was performed during the first 4 weeks to investigate whether the occurrence of this brain activity predicted development of epilepsy or not.

Results:

Of the 21 rats which received the TBI, 9 became epileptic (E+) and 12 did not (E−). HaHFOs were observed in the prefrontal and perilesional cortices, hippocampus, and striatum in both E+ and E− group. In comparison to the rats in E−, the E+ group showed a significant increase in the rate of haHFO from weeks 1 to 4 after TBI.

Conclusion:

The results indicate that an increase in the rate of haHFOs after TBI could be an electroencephalographic biomarker of posttraumatic epileptogenesis.


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About this article

High amplitude high frequency oscillations during posttraumatic epileptogenesis

Show Author's information Jagannathan Rangarajan, Udaya Kumar( )
Department of Neurology, University of California Los Angeles, Los Angeles 90024, California, U.S.A.

Abstract

Background:

The aim of the present study was to investigate if high amplitude high frequency oscillations (haHFOs) could be a biomarker of posttraumatic epileptogenesis.

Methods:

After an initial craniotomy of rats and inducement of traumatic brain injury (TBI) through a fluid percussion, recording microelectrodes were implanted bilaterally in different brain areas. Wideband brain electrical activity was recorded intermittently from Day 1 of TBI and continued till week 21. HaHFO analysis was performed during the first 4 weeks to investigate whether the occurrence of this brain activity predicted development of epilepsy or not.

Results:

Of the 21 rats which received the TBI, 9 became epileptic (E+) and 12 did not (E−). HaHFOs were observed in the prefrontal and perilesional cortices, hippocampus, and striatum in both E+ and E− group. In comparison to the rats in E−, the E+ group showed a significant increase in the rate of haHFO from weeks 1 to 4 after TBI.

Conclusion:

The results indicate that an increase in the rate of haHFOs after TBI could be an electroencephalographic biomarker of posttraumatic epileptogenesis.

Keywords: epilepsy, biomarker, traumatic brain injury, high frequency oscillations

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Publication history

Received: 27 September 2022
Revised: 05 December 2022
Accepted: 03 January 2023
Published: 05 December 2023
Issue date: December 2023

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© The authors 2023.

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This article is published with open access at journals.sagepub.com/home/BSA

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