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Objective: The aim of the present study was to investigate if high amplitude high frequency oscillations (haHFOs) could be a biomarker of posttraumatic epileptogenesis.

Methods: After an initial craniotomy of rats and inducement of traumatic brain injury (TBI) through a fluid percussion, recording microelectrodes were implanted bilaterally in different brain areas. Wideband brain electrical activity was recorded intermittently from Day 1 of TBI and continued till week 21. HaHFO analysis was performed during the first 4 weeks to investigate whether the occurrence of this brain activity predicted development of epilepsy or not.

Results: Of the 21 rats which received the TBI, 9 became epileptic (E+) and 12 did not (E−). HaHFOs were observed in the prefrontal and perilesional cortices, hippocampus, and striatum in both E+ and E− group. In comparison to the rats in E−, the E+ group showed a significant increase in the rate of haHFO from weeks 1 to 4 after TBI.

Conclusion: The results indicate that an increase in the rate of haHFOs after TBI could be an electroencephalographic biomarker of posttraumatic epileptogenesis.

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Publication history

Received: 27 September 2022
Revised: 05 December 2022
Accepted: 03 January 2023
Available online: 15 March 2023

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© The authors 2023.

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This article is published with open access at journals.sagepub.com/home/BSA.

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