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Review Article | Open Access

Activatable molecular fluorescence probes for the imaging and detection of ischemic stroke

Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China
National Engineering Research Centre for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China
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Abstract

The real-time, noninvasive, nonionizing, high spatiotemporal resolution, and flexibility characteristics of molecular fluorescence imaging provide a uniquely powerful approach to imaging and monitoring the physiology and pathophysiology of ischemic stroke. Currently, various fluorescence probes have been synthesized with the aim of improving quantitative and quantitative studies of the pathologic processes of ischemic stroke in living animals. In this review, we present an overview of current activatable fluorescence probes for the imaging and diagnosis of ischemic stroke in animal models. We categorize the probes based on their activatable signals from the biomarkers associated with ischemic stroke, and we present representative examples of their functional mechanisms. Finally, we briefly discuss future perspectives in this field.

Keywords

molecular imagingproteasemetal ionROSfluorescence probeischemic strokedetection

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Brain Science Advances
Volume 9 Issue 1,
March 2023
Pages 35-42
DOI: 10.26599/BSA.2023.9050003

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Review Status: {{reviewData.commendedNum}} Commended , {{reviewData.revisionRequiredNum}} Revision Required , {{reviewData.notCommendedNum}} Not Commended Under Peer Review

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Cite this article:
Wang M, Zhang Y. Activatable molecular fluorescence probes for the imaging and detection of ischemic stroke. Brain Science Advances, 2023, 9(1): 35-42. https://doi.org/10.26599/BSA.2023.9050003

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Received: 21 October 2022
Revised: 08 November 2022
Accepted: 08 November 2022
Published: 27 February 2023
© The authors 2023.

This article is published with open access at journals.sagepub.com/home/BSA

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).