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27 May 2022
Open Access
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Published:
27 May 2022
Role of the paraventricular nucleus of the hypothalamus in sleep–wake regulation
Zhi-Li Huang(
),
Chang-Rui Chen(
)
),
Chang-Rui Chen(
)
Cite this article:
Jiang S, Chen L, Huang Z-L, et al.
Role of the paraventricular nucleus of the hypothalamus in sleep–wake regulation.
Brain Science Advances,
2022, 8(3): 197-209.
https://doi.org/10.26599/BSA.2022.9050017
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The paraventricular nucleus of the hypothalamus (PVH) acts as a cohesive functional unit that regulates neuroendocrine and autonomic function, complex behavior, and negative emotions after stress. However, how the PVH integrates arousal with these biological functions has only recently been explored. Clinical reports, combined with neurotoxic lesioning, immunochemistry, neuronal activity recordings, and the polysomnographic analyses of genetically modified animals, have revealed that the PVH is important for the control of wakefulness. Here, we review emerging anatomical and neural mechanisms for sleep–wake regulation in the PVH to support its essential role in the promotion and maintenance of wakefulness.
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Role of the paraventricular nucleus of the hypothalamus in sleep–wake regulation
Zhi-Li Huang(
), Chang-Rui Chen(
)
), Chang-Rui Chen(
)
Abstract
The paraventricular nucleus of the hypothalamus (PVH) acts as a cohesive functional unit that regulates neuroendocrine and autonomic function, complex behavior, and negative emotions after stress. However, how the PVH integrates arousal with these biological functions has only recently been explored. Clinical reports, combined with neurotoxic lesioning, immunochemistry, neuronal activity recordings, and the polysomnographic analyses of genetically modified animals, have revealed that the PVH is important for the control of wakefulness. Here, we review emerging anatomical and neural mechanisms for sleep–wake regulation in the PVH to support its essential role in the promotion and maintenance of wakefulness.
Keywords:
circadian rhythm, paraventricular nucleus of the hypothalamus, sleep–wake regulation
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Publication history
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Publication history
Received: 01 May 2022
Revised: 02 July 2022
Accepted: 07 July 2022
Published:
27 May 2022
Issue date: September 2022
Copyright
© The authors 2022.
Acknowledgements
This study was partly supported by the National Major Project of China Science and Technology Innovation 2030 for Brain Science and Brain-Inspired Technology (Grant No. 2021ZD0203400 to Z.-L.H.), the National Natural Science Foundation of China (Grant Nos. 82020108014 and 32070984 to Z.-L.H., the Shanghai Science and Technology Innovation Action Plan Laboratory Animal Research Project (Grant No. 201409001800 to Z.-L.H.), Program for Shanghai Outstanding Academic Leaders (to Z.-L.H.), the Shanghai Municipal Science and Technology Major Project, and ZJLab (Grant No. 2018SHZDZX01 to Z-.L.H.).
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