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Brain Science Advances 2021, 7(4): 207-219 https://doi.org/10.26599/BSA.2021.9050019
Review Article | Open Access | Issue | Published: 10 January 2022

Research advances on antioxidation, neuroprotection, and molecular mechanisms of Lycium barbarum polysaccharides

Show Author's Information Cheng Wang1,§,  Liangxing Zhou1,§,  Mei Mo2,§,  Xianglin Kong2,  Zhengbin Chai1,  Lei Deng1,  Junli Zhang1,  Kuan Cao1,  Chuanfei Wei3,  Li Xu3,  Juanli Chen3,  Fabin Han1,3( )
The Innovation Institute for Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China
Experimental Centre, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China
The Institute for Tissue Engineering and Regenerative Medicine, Stem Cell and Regenerative Medicine Laboratory, Liaocheng University/Liaocheng People’s Hospital, Liaocheng 252000, Shandong, China

§ These authors contributed equally to this work.

Keywords:
neurodegenerative disease, neuroprotection, neural stem cell, oxidative stress, Lycium barbarum polysaccharide, ischemic brain injury
Cite this article:
Wang C, Zhou L, Mo M, et al. Research advances on antioxidation, neuroprotection, and molecular mechanisms of Lycium barbarum polysaccharides. Brain Science Advances, 2021, 7(4): 207-219. https://doi.org/10.26599/BSA.2021.9050019
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Abstract Full text About this article

Lycium barbarum polysaccharides (LBPs) are the major polysaccharides extracted from L. barbarum, which is used in traditional Chinese medicine (TCM) for treating diseases. Studies have shown that LBPs have important biological activities, such as antioxidation, anti-aging, neuroprotection, immune regulation. LBPs inhibit oxidative stress, improve neurodegeneration and stroke-induced neural injury, increase proliferation and differentiation of neural stem cell, and promote neural regeneration. Here we have reviewed latest advances in the biomedical activities of LBPs and improved methods for the isolation, extraction, and purification of LBPs. Then, new discoveries to decrease oxidative stress and cellular apoptosis, inhibit aging progress, and improve neural repair in neurodegeneration and ischemic brain injury have been discussed in detail through in vitro cell culture and in vivo animal studies. Importantly, the molecular mechanisms of LBPs in playing neuroprotective roles are further explored. Lastly, we discuss the perspective of LBPs as biomedical compounds in TCM and modern medicine and provide the experimental and theoretical evidence to use LBPs for the treatment of aging-related neurological diseases and stroke-induced neural injuries.


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About this article

Research advances on antioxidation, neuroprotection, and molecular mechanisms of Lycium barbarum polysaccharides

Show Author's information Cheng Wang1,§, Liangxing Zhou1,§, Mei Mo2,§, Xianglin Kong2, Zhengbin Chai1, Lei Deng1, Junli Zhang1, Kuan Cao1, Chuanfei Wei3, Li Xu3, Juanli Chen3, Fabin Han1,3( )
The Innovation Institute for Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China
Experimental Centre, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China
The Institute for Tissue Engineering and Regenerative Medicine, Stem Cell and Regenerative Medicine Laboratory, Liaocheng University/Liaocheng People’s Hospital, Liaocheng 252000, Shandong, China

§ These authors contributed equally to this work.

Abstract

Lycium barbarum polysaccharides (LBPs) are the major polysaccharides extracted from L. barbarum, which is used in traditional Chinese medicine (TCM) for treating diseases. Studies have shown that LBPs have important biological activities, such as antioxidation, anti-aging, neuroprotection, immune regulation. LBPs inhibit oxidative stress, improve neurodegeneration and stroke-induced neural injury, increase proliferation and differentiation of neural stem cell, and promote neural regeneration. Here we have reviewed latest advances in the biomedical activities of LBPs and improved methods for the isolation, extraction, and purification of LBPs. Then, new discoveries to decrease oxidative stress and cellular apoptosis, inhibit aging progress, and improve neural repair in neurodegeneration and ischemic brain injury have been discussed in detail through in vitro cell culture and in vivo animal studies. Importantly, the molecular mechanisms of LBPs in playing neuroprotective roles are further explored. Lastly, we discuss the perspective of LBPs as biomedical compounds in TCM and modern medicine and provide the experimental and theoretical evidence to use LBPs for the treatment of aging-related neurological diseases and stroke-induced neural injuries.

Keywords: neurodegenerative disease, neuroprotection, neural stem cell, oxidative stress, Lycium barbarum polysaccharide, ischemic brain injury

References(46)

[1]
Wu HT, He XJ, Hong YK, et al. Chemical characterization of Lycium barbarum polysaccharides and its inhibition against liver oxidative injury of high-fat mice. Int J Biol Macromol 2010, 46(5): 540-543.
DOI Google Scholar
[2]
Masci A, Carradori S, Casadei MA, et al. Lycium barbarum polysaccharides: Extraction, purification, structural characterisation and evidence about hypoglycaemic and hypolipidaemic effects. A review. Food Chem 2018, 254: 377-389.
DOI Google Scholar
[3]
Tian X, Liang T, Liu Y, et al. Extraction, structural characterization, and biological functions of polysaccharides: A review. Biomolecules 2019, 9(9): 389.
DOI Google Scholar
[4]
Ni JG, Au M, Kong H, et al. Lycium barbarum polysaccharides in ageing and its potential use for prevention and treatment of osteoarthritis: a systematic review. BMC Complement Med Ther 2021, 21(1): 212.
DOI Google Scholar
[5]
Zhou S, Rahman A, Li J, et al. Extraction methods affect the structure of Goji (Lycium barbarum) polysaccharides. Molecules 2020, 25(4): 936.
DOI Google Scholar
[6]
Zhang J, Jia SY, Liu Y, et al. Optimization of enzyme-assisted extraction of the Lycium barbarum polysaccharides using response surface methodology. Carbohydr Polym 2011, 86(2): 1089-1092.
DOI Google Scholar
[7]
Hao W, Wang SF, Zhao J, et al. Effects of extraction methods on immunology activity and chemical profiles of Lycium barbarum polysaccharides. J Pharm Biomed Anal 2020, 185: 113219.
DOI Google Scholar
[8]
Liu ZG, Dang J, Wang QL, et al. Optimization of polysaccharides from Lycium ruthenicum fruit using RSM and its anti-oxidant activity. Int J Biol Macromol 2013, 61: 127-134.
DOI Google Scholar
[9]
Muatasim R, Ma H, Yang X. Effect of multimode ultrasound assisted extraction on the yield of crude polysaccharides from Lycium barbarum (Goji). Food Sci Technol Campinas 2018, 38(suppl.1): 160-166.
DOI Google Scholar
[10]
Cheng XL, Wan JY, Li P, et al. Ultrasonic/microwave assisted extraction and diagnostic ion filtering strategy by liquid chromatography-quadrupole time-of-flight mass spectrometry for rapid characterization of flavonoids in Spatholobus suberectus. J Chromatogr A 2011, 1218(34): 5774-5786.
DOI Google Scholar
[11]
Zeng PJ, Li J, Chen YL, et al. The structures and biological functions of polysaccharides from traditional Chinese herbs. Prog Mol Biol Transl Sci 2019, 163: 423-444.
DOI Google Scholar
[12]
Zhao R, Qiu B, Li QW, et al. LBP-4a improves insulin resistance via translocation and activation of GLUT4 in OLETF rats. Food Funct 2014, 5(4): 811-820.
DOI Google Scholar
[13]
Yang K, Lu TT, Zhan LH, et al. Physicochemical characterization of polysaccharide from the leaf of Dendrobium officinale and effect on LPS induced damage in GES-1 cell. Int J Biol Macromol 2020, 149: 320-330.
DOI Google Scholar
[14]
Li XM, Ma YL, Liu XJ. Effect of the Lycium barbarum polysaccharides on age-related oxidative stress in aged mice. J Ethnopharmacol 2007, 111(3): 504-511.
DOI Google Scholar
[15]
Liu L, Sha XY, Wu YN, et al. Lycium barbarum polysaccharides protects retinal ganglion cells against oxidative stress injury. Neural Regen Res 2020, 15(8): 1526-1531.
DOI Google Scholar
[16]
Xue SJ, Hu XH, Zhu L, et al. Protective functions of Lycium barbarum polysaccharides in H2O2-injured vascular endothelial cells through anti-oxidation and anti-apoptosis effects. Biomed Rep 2019, 11(5): 207-214.
DOI Google Scholar
[17]
Gong GP, Dang TT, Deng YN, et al. Physicochemical properties and biological activities of polysaccharides from Lycium barbarum prepared by fractional precipitation. Int J Biol Macromol 2018, 109: 611-618.
DOI Google Scholar
[18]
Chen L, Li W, Qi D, et al. Lycium barbarum polysaccharide protects against LPS-induced ARDS by inhibiting apoptosis, oxidative stress, and inflammation in pulmonary endothelial cells. Free Radic Res 2018, 52(4): 480-490.
DOI Google Scholar
[19]
Xue M-Q, Quan H-F, Wang R, et al. Mitigation of chronic unpredictable stress-induced cognitive deficits in mice by Lycium barbarum L (Solanaceae) polysaccharides. Trop J Pharm Res 2017, 16: 1893-1901.
DOI Google Scholar
[20]
Liang R, Zhao Q, Zhu Q, et al. Lycium barbarum polysaccharide-based protection to combat H2O2-induced oxidative stress via the Nrf2/HO-1 pathway in ARPE-19 cells. Mol Med Rep 2021, 24(5): 769.
DOI Google Scholar
[21]
Enwere EK, Lacasse EC, Adam NJ, et al. Role of the TWEAK-Fn14-cIAP1-NF-κB signaling axis in the regulation of myogenesis and muscle homeostasis. Front Immunol 2014, 5: 34.
DOI Google Scholar
[22]
Chen SW, Dong YS, Xu C, et al. Involvement of a chromatin modifier in response to mono-(2-ethylhexyl) phthalate (MEHP)-induced Sertoli cell injury: probably an indirect action via the regulation of NFκB/FasL circuitry. Biochem Biophys Res Commun 2013, 440(4): 749-755.
DOI Google Scholar
[23]
Wu Q, Liu LT, Wang XY, et al. Lycium barbarum polysaccharides attenuate kidney injury in septic rats by regulating Keap1-Nrf2/ARE pathway. Life Sci 2020, 242: 117240.
DOI Google Scholar
[24]
Yi R, Liu XM, Dong Q. A study of Lycium barbarum polysaccharides (LBP) extraction technology and its anti-aging effect. Afr J Tradit Complement Altern Med 2013, 10(4): 171-174.
DOI Google Scholar
[25]
Wang XH, Pang L, Zhang YQ, et al. Lycium barbarum polysaccharide promotes nigrostriatal dopamine function by modulating PTEN/AKT/mTOR pathway in a methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) murine model of Parkinson’s disease. Neurochem Res 2018, 43(4): 938-947.
DOI Google Scholar
[26]
Long HZ, Cheng Y, Zhou ZW, et al. PI3K/AKT signal pathway: a target of natural products in the prevention and treatment of Alzheimer's disease and Parkinson’s disease. Front Pharmacol 2021, 12: 648636.
DOI Google Scholar
[27]
Hu J, Yang J, Zhang KY, et al. Protective effect of LBP on injured optic nerve in rats (in Chinese). J Ningxia Med Univ 2017, 39(1): 30-33, 117.
Google Scholar
[28]
Lakshmanan Y, Wong FSY, Yu WY, et al. Lycium barbarum polysaccharides rescue neurodegeneration in an acute ocular hypertension rat model under pre- and posttreatment conditions. Invest Ophthalmol Vis Sci 2019, 60(6): 2023-2033.
DOI Google Scholar
[29]
Li HY, Huang M, Luo QY, et al. Lycium barbarum (wolfberry) increases retinal ganglion cell survival and affects both microglia/macrophage polarization and autophagy after rat partial optic nerve transection. Cell Transplant 2019, 28(5): 607-618.
DOI Google Scholar
[30]
Schüler T, Mesic I, Madry C, et al. Formation of NR1/NR2 and NR1/NR3 heterodimers constitutes the initial step in N-methyl-D-aspartate receptor assembly. J Biol Chem 2008, 283(1): 37-46.
DOI Google Scholar
[31]
Lai TW, Zhang S, Wang YT. Excitotoxicity and stroke: identifying novel targets for neuroprotection. Prog Neurobiol 2014, 115: 157-188.
DOI Google Scholar
[32]
Gladding CM, Raymond LA. Mechanisms underlying NMDA receptor synaptic/extrasynaptic distribution and function. Mol Cell Neurosci 2011, 48(4): 308-320.
DOI Google Scholar
[33]
Shi Z, Zhu L, Li T, et al. Neuroprotective mechanisms of polysaccharides against ischemic insults by regulating NR2B and NR2A containing NMDA receptor signaling pathways. Front Cell Neurosci 2017, 11: 288.
DOI Google Scholar
[34]
Song YJ, Zhao XF, Wang D, et al. Inhibition of LPS-induced brain injury by NR2B antagonists through reducing assembly of NR2B-CaMKII-PSD95 signal module. Immunopharmacol Immunotoxicol 2019, 41(1): 86-94.
DOI Google Scholar
[35]
Vonk WIM, Rainbolt TK, Dolan PT, et al. Differentiation drives widespread rewiring of the neural stem cell chaperone network. Mol Cell 2020, 78(2): 329-345.e9.
DOI Google Scholar
[36]
Fritze J, Ginisty A, McDonald R, et al. Loss of Cxcr5 alters neuroblast proliferation and migration in the aged brain. Stem Cells 2020, 38(9): 1175-1187.
DOI Google Scholar
[37]
Tian J-Y, Chen W-W, Cui J, et al. Effect of polysaccharides on methylmercury-induced abnormal differentiation of hippocampal stem cells. Exp Ther Med 2016, 12(2): 683-689.
DOI Google Scholar
[38]
Mi XS, Feng Q, Lo ACY, et al. Lycium barbarum polysaccharides related RAGE and Aβ levels in the Retina of mice with acute ocular hypertension and promote maintenance of blood retinal barrier. Neural Regen Res 2020, 15(12): 2344-2352.
DOI Google Scholar
[39]
Neelam K, Dey S, Sim R, et al. Fructus lycii: a natural dietary supplement for amelioration of retinal diseases. Nutrients 2021, 13(1): 246.
DOI Google Scholar
[40]
Liu K, Yang YC, Zhou F, et al. Inhibition of PI3K/ AKT/mTOR signaling pathway promotes autophagy and relieves hyperalgesia in diabetic rats. Neuroreport 2020, 31(9): 644-649.
DOI Google Scholar
[41]
Wang JH, Yao Y, Liu XZ, et al. Protective effects of Lycium barbarum polysaccharides on blood-retinal barrier via ROCK1 pathway in diabetic rats. Am J Transl Res 2019, 11(10): 6304-6315.
Google Scholar
[42]
Chen WW, Cheng X, Chen JZ, et al. Lycium barbarum polysaccharides prevent memory and neurogenesis impairments in scopolamine-treated rats. PLoS One 2014, 9(2): e88076.
DOI Google Scholar
[43]
Zhao P, Zhou R, Zhu XY, et al. Neuroprotective effects of Lycium barbarum polysaccharide on focal cerebral ischemic injury in mice. Neurochem Res 2017, 42(10): 2798-2813.
DOI Google Scholar
[44]
Zhou Y, Duan YH, Huang SC, et al. Polysaccharides from Lycium barbarum ameliorate amyloid pathology and cognitive functions in APP/PS1 transgenic mice. Int J Biol Macromol 2020, 144: 1004-1012.
DOI Google Scholar
[45]
Cao SM, Du JL, Hei QH. Lycium barbarum polysaccharide protects against neurotoxicity via the Nrf2-HO-1 pathway. Exp Ther Med 2017, 14(5): 4919-4927.
DOI Google Scholar
[46]
Wang J, Tian LL, He LM, et al. Lycium barbarum polysaccharide encapsulated Poly lactic-co-glycolic acid Nanofibers: cost effective herbal medicine for potential application in peripheral nerve tissue engineering. Sci Rep 2018, 8(1): 8669.
DOI Google Scholar
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Published: 10 January 2022
Issue date: December 2021

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