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Review Article | Open Access

Advances in the study of nervous system infections in COVID-19

Chao He1,§, Ling He2,§, Lin Chen3,†( ), Wei Wang4,†( )
Department of Neurosurgery, Zhuji Affiliated Hospital of Shaoxing University, Shaoxing 300800, Zhejiang, China
Darwin Cell Biotechnology Co., Ltd., Beijing 100124, China
Department of Neurosurgery, Center for Brain Diseases, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
Department of Intensive Care Unit, Zhuji Affiliated Hospital of Wenzhou Medical University, Wenzhou 300800, Zhejiang, China

§ These authors contributed equally to this work.

† These authors contributed equally to this work.

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Abstract

Shortly after its outbreak, coronavirus disease 2019 (COVID-19) has very rapidly spread to become a global epidemic. Early clinical findings mainly included typical symptoms such as fever and cough with a very high transmission rate. Recent findings have demonstrated neurological manifestations of atypical symptoms, which is associated with poor prognosis. In this paper, we describe the neurological aspects of COVID-19 pneumonia in terms of relevant neurons, virus-associated receptors, and olfactory and neurological clinical manifestations and offer insights on treatment.

Keywords

SARS-CoV-2COVID-19olfactionnervous system

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Brain Science Advances
Volume 7 Issue 3,
September 2021
Pages 163-171
DOI: 10.26599/BSA.2021.9050014

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Cite this article:
He C, He L, Chen L, et al. Advances in the study of nervous system infections in COVID-19. Brain Science Advances, 2021, 7(3): 163-171. https://doi.org/10.26599/BSA.2021.9050014

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Received: 24 March 2021
Revised: 15 June 2021
Accepted: 21 June 2021
Published: 08 December 2021
© The authors 2021

This article is published with open access at journals.sagepub.com/home/BSA

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).