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Review Article | Open Access

Sleep-based therapy: A new treatment for amyotrophic lateral sclerosis

Qing Cai1, Mengya Li1, Qifang Li1,2( )
Department of Curative Anesthesia, Ruijin Hospital Luwan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China
Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China
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Abstract

Amyotrophic lateral sclerosis (ALS) is a worldwide problem with no effective treatment. Patients usually die of respiratory failure. The basic pathological process of ALS is the degeneration and necrosis of motor neurons. Neuroglial cell dysfunction is considered closely related to the development of ALS. Sleep plays an important role in repairing the nervous system, and sleep disorders can worsen ALS. Herein, we review the pathogenesis of ALS and the neuroprotective mechanism of sleep-based therapy. Sleep-based therapy could be a potential strategy to treat ALS.

Keywords

amyotrophic lateral sclerosissleep therapyneuroglial cellsdexmedetomidineanticholinergic drugs

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Brain Science Advances
Volume 7 Issue 3,
September 2021
Pages 155-162
DOI: 10.26599/BSA.2021.9050010
Cite this article:
Cai Q, Li M, Li Q. Sleep-based therapy: A new treatment for amyotrophic lateral sclerosis. Brain Science Advances, 2021, 7(3): 155-162. https://doi.org/10.26599/BSA.2021.9050010

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Received: 06 January 2021
Revised: 03 June 2021
Accepted: 04 June 2021
Published: 08 December 2021
© The authors 2021

This article is published with open access at journals.sagepub.com/home/BSA

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
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