AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Brain Science Advances Article
PDF (3.2 MB)
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript AI Chat Paper
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Research Article | Open Access

Cerebrospinal fluid heart fatty acid-binding protein as a predictive biomarker of neurodegeneration in Alzheimer’s disease

Lu Pan1, Ya-Nan Ou2, Lin Tan2, Lan Tan1,2( ), Jin-Tai Yu3( )
Department of Neurology, Qingdao Municipal Hospital, Dalian Medical University, Dalian 116044, Liaoning, China.
Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, Shandong, China.
Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China
Show Author Information

Abstract

Objective:

This study aims to investigate whether the heart fatty acid-binding protein (HFABP) in the cerebrospinal fluid (CSF) was a potential predictive biomarker for Alzheimer’s disease (AD).

Methods:

We evaluated the associations of CSF HFABP levels with core biomarkers, cognition, and brain structure in a sample population (n = 302) from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. Multiple linear regression and mixed-effects models were employed in the analyses. AD progression was assessed using the Kaplan–Meier survival analysis.

Results:

CSF HFABP was higher in patients with mild cognitive impairment and AD than the normal controls (p < 0.001) and was particularly higher in those with amyloid-β (Aβ) pathologic features. CSF HFABP was associated with higher baseline CSF t-tau (p < 0.001), CSF p-tau (p < 0.001), and CSF t-tau/Aβ42 and CSF p-tau/Aβ42 (p < 0.01). Moreover, CSF HFABP was found to play predictive roles in hippocampal atrophy (p < 0.01), cognitive decline (p < 0.05), and the risk of AD (p < 0.001).

Conclusion:

Our findings suggest that CSF HFABP can be a predictive biomarker of AD.

Keywords

Alzheimer’s diseaseheart fatty acid-binding protein (HFABP)cerebrospinal fluidbiomarkerneurodegeneration

References

【1】
【1】
 
 
Crossref Google Scholar
Brain Science Advances
Volume 7 Issue 1,
March 2021
Pages 44-55
DOI: 10.26599/BSA.2021.9050003

{{item.num}}

Comments on this article

Go to comment

< Back to all reports

Review Status: {{reviewData.commendedNum}} Commended , {{reviewData.revisionRequiredNum}} Revision Required , {{reviewData.notCommendedNum}} Not Commended Under Peer Review

Review Comment

Cite this Report
Close
Close
Cite this article:
Pan L, Ou Y-N, Tan L, et al. Cerebrospinal fluid heart fatty acid-binding protein as a predictive biomarker of neurodegeneration in Alzheimer’s disease. Brain Science Advances, 2021, 7(1): 44-55. https://doi.org/10.26599/BSA.2021.9050003

1520

Views

234

Downloads

1

Crossref
Received: 02 November 2020
Revised: 22 February 2021
Accepted: 28 February 2021
Published: 05 March 2021
© The authors 2021

This article is published with open access at journals.sagepub.com/home/BSA

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/ en-us/nam/open-access-at-sage).