There are two major research issues with regard to detoxification; one is pathological testing of drug users and the other is rehabilitation methods and techniques. Over the years, domestic and foreign researchers have done a lot of work on pathological changes in the brain and rehabilitation techniques for drug users. This article discusses the research status of these two aspects. At present, the evaluation of brain function in drug addicts is still dominated by a single electroencephalography (EEG), near- infrared spectroscopy (NIRS), or magnetic resonance imaging scan. The multimodal physiological data acquisition method based on EEG–NIRS technique is relatively advantageous for actual physiological data acquisition. The traditional drug rehabilitation method is based on medication and psychological counseling. In recent years, psychological correction (e.g., emotional ventilation, intelligent physical and mental decompression, virtual reality technique and drug addiction suppression system, sports training, and rehabilitation) and physical therapy (transcranial magnetic stimulation) have gradually spread. These rehabilitations focus on comprehensive treatment from the psychological and physical aspects. In recent years, new intervention ideas such as brain–computer interface technique have been continuously proposed. In this review, we have introduced multimodal brain function detection and rehabilitation intervention, which have theoretical and practical significance in drug rehabilitation research.