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18 May 2020
A review on the ongoing quest for a pain signature in the human brain
Meng Liang2(
)
)
Cite this article:
Su Q, Song Y, Zhao R, et al.
A review on the ongoing quest for a pain signature in the human brain.
Brain Science Advances,
2019, 5(4): 274-287.
https://doi.org/10.26599/BSA.2019.9050024
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Developing an objective biomarker for pain assessment is crucial for understanding neural coding mechanisms of pain in the human brain as well as for effective treatment of pain disorders. Neuroimaging techniques have been proven to be powerful tools in the ongoing quest for a pain signature in the human brain. Although there is still a long way to go before achieving a truly successful pain signature based on neuroimaging techniques, important progresses have been made through great efforts in the last two decades by the Pain Society. Here, we focus on neural responses to transient painful stimuli in healthy people, and review the relevant studies on the identification of a neuroimaging signature for pain.
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A review on the ongoing quest for a pain signature in the human brain
Meng Liang2(
)
)
Abstract
Developing an objective biomarker for pain assessment is crucial for understanding neural coding mechanisms of pain in the human brain as well as for effective treatment of pain disorders. Neuroimaging techniques have been proven to be powerful tools in the ongoing quest for a pain signature in the human brain. Although there is still a long way to go before achieving a truly successful pain signature based on neuroimaging techniques, important progresses have been made through great efforts in the last two decades by the Pain Society. Here, we focus on neural responses to transient painful stimuli in healthy people, and review the relevant studies on the identification of a neuroimaging signature for pain.
Keywords:
pain signature, neuroimaging, machine learning, saliency, MVPA, specificity
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Publication history
Received: 02 November 2019
Revised: 14 December 2019
Accepted: 15 December 2019
Published:
18 May 2020
Issue date: December 2019
Copyright
© The authors 2019
Acknowledgements
This work was supported by National Natural Science Foundation of China (No. 81571659, No. 81971694). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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