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Affective disorders are often accompanied by circadian rhythm disruption and the major symptoms of mental illness occur in a rhythmic manner. Chronotype, also known as circadian preference for rest or activity, is believed to exert a substantial influence on mental health. Here, we review the connection between chronotypes and affective disorders, and discuss the potential underlying mechanisms between these two phenomena.

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Chronotypes and affective disorders: A clock for mood?

Show Author's information Qian Gao1Juan Sheng2Song Qin2Luoying Zhang1( )
Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology and the Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China
Jingzhou Mental Health Center, Jingzhou 434000, Hubei, China


Affective disorders are often accompanied by circadian rhythm disruption and the major symptoms of mental illness occur in a rhythmic manner. Chronotype, also known as circadian preference for rest or activity, is believed to exert a substantial influence on mental health. Here, we review the connection between chronotypes and affective disorders, and discuss the potential underlying mechanisms between these two phenomena.

Keywords: chronotype, affective disorder, circadian clock, clock gene


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Received: 22 July 2019
Revised: 31 August 2019
Accepted: 01 September 2019
Published: 17 April 2020
Issue date: September 2019


© The authors 2019


This work was supported by grants from the Natural Science Foundation of China (No. 31930021, No. 31671360) to Luoying Zhang, and China Postdoctoral Science Foundation (No. 2018M632826) to Qiang Gao.

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