Journal Home > Volume 5 , Issue 3

Parkinson’s disease (PD) is a progressive neurodegenerative disorder commonly observed in middle-aged and elderly. Currently, its etiology and pathogenesis are still not completely understood. It is associated with many symptoms that severely affect patients’ health and quality of life. At present, the PD clinical treatment mainly aimed to alleviate symptoms, and both medicinal and surgical treatments have side effects and treatment blind spots. The use of acupuncture for the treatment of PD is relatively widespread, and its safety and efficacy have been gradually accepted by the public and medical professions. However, the efficacy of acupuncture in experimental studies remains controversial. Therefore, this paper reviews imaging studies on the use of acupuncture for the treatment of PD. From the study, it shows that acupuncture can improve the neuronal activity, activate the neuronal activity in damaged brain regions, affect relevant neural networks and brain circulation, improve cerebral metabolism, and cause structural changes in related brain regions. Intuitive and visible imaging studies provide objective bases on the use of acupuncture for the treatment of PD.


menu
Abstract
Full text
Outline
About this article

The development of visual neuroimaging research of acupuncture in the treatment of Parkinson’s disease

Show Author's information Yuan Yang1,2Suhua Miao2Rongsong Zhou2Yu Ma2( )Yuqi Zhang1,2( )
School of Medicine, Tsinghua University, Beijing 100084, China
Department of Neurosurgery, Yuquan Hospital, Tsinghua University, Beijing 100040, China

Abstract

Parkinson’s disease (PD) is a progressive neurodegenerative disorder commonly observed in middle-aged and elderly. Currently, its etiology and pathogenesis are still not completely understood. It is associated with many symptoms that severely affect patients’ health and quality of life. At present, the PD clinical treatment mainly aimed to alleviate symptoms, and both medicinal and surgical treatments have side effects and treatment blind spots. The use of acupuncture for the treatment of PD is relatively widespread, and its safety and efficacy have been gradually accepted by the public and medical professions. However, the efficacy of acupuncture in experimental studies remains controversial. Therefore, this paper reviews imaging studies on the use of acupuncture for the treatment of PD. From the study, it shows that acupuncture can improve the neuronal activity, activate the neuronal activity in damaged brain regions, affect relevant neural networks and brain circulation, improve cerebral metabolism, and cause structural changes in related brain regions. Intuitive and visible imaging studies provide objective bases on the use of acupuncture for the treatment of PD.

Keywords: neuroimaging, acupuncture, neuronal activity, Parkinson’s disease

References(35)

[1]
ZX Zhang, GC Roman, Z Hong, et al. Parkinson's disease in China: prevalence in Beijing, Xi’an, and Shanghai. Lancet. 2005, 365(9459): 595-597.
[2]
ER Dorsey, R Constantinescu, JP Thompson, et al. Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030. Neurology. 2007, 68(5): 384-386.
[3]
Y Wang, S Yin, WG Liu, et al. Investigation on economic burden of disease and its related influence factors in patients with Parkinson disease. J Clin Neurol. 2011, 24(6): 427-430.
[4]
SD Chen, W Chen. Recognition and treatment of non-motor symptoms of Parkinson’s disease: from neglect to attention (in Chinese). Chin J Neurol. 2012, 45(6): 361-363.
[5]
J Gan, MZ Zhou, W Chen, et al. Non-motor symptoms in Chinese Parkinson’s disease patients. J Clin Neurosci. 2014, 21(5): 751-754.
[6]
Chinese Society of Neurology Parkinson’s disease and Motor Disorder Group. Parkinson’s disease Treatment Guidelines in China (3rd edition) (in Chinese). Chin J Neurol. 2014, 47(6): 428-433.
[7]
MA Hely, JG Morris, WG Reid, et al. Sydney Multicenter Study of Parkinson’s disease: non-L- dopa-responsive problems dominate at 15 years. Mov Disord. 2005, 20(2): 190-199.
[8]
BY Zeng, S Salvage, P Jenner. Current development of acupuncture research in Parkinson’s disease. Int Rev Neurobiol. 2013, 111: 141-158.[PubMed]
[9]
A Cristian, M Katz, E Cutrone, et al. Evaluation of acupuncture in the treatment of Parkinson's disease: a double-blind pilot study. Mov Disord. 2005, 20(9): 1185-1188.
[10]
Y Chae, H Lee, H Kim, et al. Parsing brain activity associated with acupuncture treatment in Parkinson’s diseases. Mov Disord. 2009, 24(12): 1794-1802.
[11]
YL Chen, WJ Feng, XL Zhang. Parkinson's disease combined with overactive bladder syndrome treated with acupuncture and medication. Chin Acupunct Moxibustion. 2012, 32(3): 215-218.
[12]
SY Cho, SR Shim, HY Rhee, et al. Effectiveness of acupuncture and bee venom acupuncture in idiopathic Parkinson’s disease. Parkinsonism Relat Disord. 2012, 18(8): 948-952.
[13]
H Lei, N Toosizadeh, M Schwenk, et al. Objective assessment of electro-acupuncture benefit for improving balance and gait in patients with Parkinson’s disease. Neurology. 2014, 82(Suppl 10): P3.074.
[14]
Y Yuan, F Chen, JS Yang. Forty-nine cases of Parkinson’s disease treated by acupuncture adjunctive therapy. Chin Acupunct Moxibustion. 2014, 34(1): 53-54.
[15]
LM Shulman, X Wen, WJ Weiner, et al. Acupuncture therapy for the symptoms of Parkinson’s disease. Mov Disord. 2002, 17(4): 799-802.
[16]
X Liang, F Chen. The effects of the seven acupoints of the cranial base on health related quality of life for patients with Parkinson’s disease: A randomized controlled trial (in Chinese). Int J Trad Chin Med. 2014, 36(7): 613-616.
[17]
S Yeo, IH Choe, M van den Noort, et al. Acupuncture on GB34 activates the precentral gyrus and prefrontal cortex in Parkinson’s disease. BMC Complement Altern Med. 2014, 14: 336.
[18]
S Yeo, M van den Noort, P Bosch, et al. Ipsilateral putamen and insula activation by both left and right GB34 acupuncture stimulation: an fMRI study on healthy participants. Evid Based Complement Alternat Med. 2016, 2016: 4173185.
[19]
F Wang, A Li, XL Li, et al. Homogeneity differences in local brain functional region in resting state magnetic resonance imaging before and after acupuncture treatment of Parkinson’s disease (in Chinese). Chin J Gerontol. 2014. 34(21): 5947-5949.
[20]
Y Huang, XM Jiang, Y Zhuo, et al. Complementary acupuncture in Parkinson’s disease: a spect study. Int J Neurosci. 2010, 120(2): 150-154.
[21]
Y Huang, Y Zhuo, XM Jiang, et al. Effect of scalp acupuncture on regional cerebral blood flow in Parkinson’s disease patients. China J Tradit Chin Med Pharm. 2009, 24(3): 305-308.
[22]
XM Jiang, Y Huang, DJ Li, et al. Effect of electro- scalp acupuncture on cerebral dopamine transporter in the striatum area of the patient of Parkinson’s disease by means of single photon emission computer tomography. Chin Acupunct Moxibustion. 2006, 26(6): 427-430.
[23]
Y Huang, XM Jiang, Y Zhuo, et al. Complementary acupuncture treatment increases cerebral metabolism in patients with Parkinson’s disease. Int J Neurosci. 2009, 119(8): 1190-1197.
[24]
F Wang, L Liu, XL Li, et al. The Evaluation of SWI in Changes of SNc of Parkinsons Disease after Acupuncture Treatment. Clin Acupunct Moxibustion. 2012. 28(6): 24-26.
[25]
SH Lee, GH Jahng, IH Choe, et al. Neural pathway interference by retained acupuncture: a functional MRI study of a dog model of Parkinson’s disease. CNS Neurosci Ther. 2013, 19(8): 585-595.
[26]
R Zhang, AH Andersen, PA Hardy, et al. Objectively measuring effects of electro-acupuncture in parkinsonian rhesus monkeys. Brain Res. 2018, 1678: 12-19.
[27]
Z Lu, X Hua, HS Cui. Research progress on clinical efficacy and mechanism of scalp acupuncture for Parkinson’s disease (in Chinese). Shanghai J Trad Chin Med. 2015, 49(5): 114-117.
[28]
SN Kim, AR Doo, JY Park, et al. Acupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of Parkinson’s disease. PLoS One. 2011, 6(11): e27566.
[29]
HM Wang, XB Liang, X Wang, et al. Electro- acupuncture stimulation improves spontaneous locomotor hyperactivity in MPTP intoxicated mice. PLoS One. 2013, 8(5): e64403.
[30]
Y Yu, K Wang, JH Deng, et al. Electroacupuncture produces the sustained motor improvement in 6- hydroxydopamine-lesioned mice. PLoS One. 2016, 11(2): e0149111.
[31]
AR Doo, ST Kim, SN Kim, et al. Neuroprotective effects of bee venom pharmaceutical acupuncture in acute 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine- induced mouse model of Parkinson's disease. Neurol Res. 2010, 32(Suppl 1): 88-91.
[32]
ST Kim, W Moon, Y Chae, et al. The effect of electroaucpuncture for 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced proteomic changes in the mouse striatum. J Physiol Sci. 2010, 60(1): 27-34.
[33]
WK Khalil, N Assaf, SA ElShebiney, et al. Neuroprotective effects of bee venom acupuncture therapy against rotenone-induced oxidative stress and apoptosis. Neurochem Int. 2015, 80: 79-86.
[34]
JG Lin, CJ Chen, HB Yang, et al. Electroacupuncture promotes recovery of motor function and reduces dopaminergic neuron degeneration in rodent models of Parkinson’s disease. Int J Mol Sci. 2017, 18(9): E1846.
[35]
T Tian, YH Sun, HG Wu, et al. Acupuncture promotes mTOR-independent autophagic clearance of aggregation-prone proteins in mouse brain. Sci Rep. 2016, 6: 19714.
Publication history
Copyright
Rights and permissions

Publication history

Received: 18 June 2019
Revised: 18 July 2019
Accepted: 28 July 2019
Published: 17 April 2020
Issue date: September 2019

Copyright

© The authors 2019

Rights and permissions

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage)

Return