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Research Article | Open Access

Plasma neurofilament light as a longitudinal biomarker of neurodegeneration in Alzheimer’s disease

Ya-Nan Ou1, Hao Hu1, Zuo-Teng Wang2, Wei Xu1, Lan Tan1( ), Jin-Tai Yu3( )
Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, Shandong, China
College of Medicine and Pharmaceutics, Ocean University of China, Qingdao 266100, Shandong, China
Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200433, China
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Abstract

Objective:

To examine whether plasma neurofilament light (NFL) might be a potential longitudinal biomarker for Alzheimer’s disease (AD).

Methods:

A total of 835 individuals from the Alzheimer’s Disease Neuroimaging Initiative were involved. Correlations of the rate of change in plasma NFL with cerebrospinal fluid biomarkers, cognition, and brain structure were investigated. Cox proportional hazards models were used to assess the associations between quartiles of plasma NFL and the risk of AD conversion.

Results:

Participants were further divided into β amyloid-positive (Aβ+) versus β amyloid-negative (Aβ−), resulting in five biomarker group combinations, which are CN Aβ−, CN Aβ+, MCI Aβ−, MCI Aβ+ and AD Aβ+. Plasma NFL concentration markedly increased in the five groups longitudinally (p < 0.001) with the greatest rate of change in AD Aβ+ group. The rate of change in plasma NFL was associated with cognitive deficits and neuroimaging hallmarks of AD over time (p < 0.005). Compared with the bottom quartile, the top quartile of change rate was associated with a 5.41-fold increased risk of AD (95% CI = 1.83−16.01) in the multivariate model.

Conclusion:

Our finding implies the potential of plasma NFL as a longitudinal noninvasive biomarker in AD.

Keywords

Alzheimer’s diseaseplasma neurofilament light (NFL)longitudinalneurodegeneration

References

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Brain Science Advances
Volume 5 Issue 2,
June 2019
Pages 94-105
DOI: 10.26599/BSA.2019.9050011

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Cite this article:
Ou Y-N, Hu H, Wang Z-T, et al. Plasma neurofilament light as a longitudinal biomarker of neurodegeneration in Alzheimer’s disease. Brain Science Advances, 2019, 5(2): 94-105. https://doi.org/10.26599/BSA.2019.9050011

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Received: 01 May 2019
Revised: 24 May 2019
Accepted: 14 June 2019
Published: 17 January 2020
© The authors 2019

This article is published with open access at journals.sagepub.com/home/BSA

Creative Commons Non Commercial CC BY- NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).