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Review | Open Access

An in-depth overview of the molecular mechanisms governing ovarian aging and the corresponding preventative and therapeutic strategies

Yanyan Fu1Yingshi Cao1Yifei Yan2Sini Huang1Shumin Li3Yanhao Huang3Zhixian Wang3Lijuan Gao3( )Chanchan Xiao3,4,5( )
Guangzhou Baiyun District Maternal and Child Health Hospital, Guangzhou 510632, China
School of Medicine, Guangdong Medical University, Zhanjiang 524023, China
Department of Microbiology and Immunology, Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou 510632, China
The Sixth Affiliated Hospital, Jinan University, Guangzhou 510632, China
Zhuhai Institute of Jinan University, Jinan University, Zhuhai 519070, China
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Abstract

Ovarian aging is a progressive and dynamic process closely related to age, in which ovarian function gradually declines until exhaustion; this process is influenced by a combination of factors, including genetics, lifestyle, environment, psychosocial factors, and iatrogenic factors. It is closely related to the quantity and quality of follicles in the ovaries and is characterized by changes in female hormone levels and fertility. Therefore, understanding the factors influencing ovarian aging, its molecular mechanisms, and strategies for prevention and intervention is of significant importance for comprehending and addressing the challenges posed by ovarian aging.

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Aging Research
Article number: 9340023

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Cite this article:
Fu Y, Cao Y, Yan Y, et al. An in-depth overview of the molecular mechanisms governing ovarian aging and the corresponding preventative and therapeutic strategies. Aging Research, 2024, 2(1): 9340023. https://doi.org/10.26599/AGR.2024.9340023

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Received: 27 April 2024
Revised: 01 June 2024
Accepted: 03 June 2024
Published: 03 July 2024
© The Author(s) 2024. Aging Research published by Tsinghua University Press.

The articles published in this open access journal are distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.