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Review | Open Access

Human T cell development and aging: Remodeling throughout the lifespan

Lipeng Mao1,2, Qiuyue Feng1,2, Oscar Junhong Luo2, Guobing Chen3, Xiao Sean Leng4( )
Department of Microbiology and Immunology; Institute of Geriatric Immunology; School of Medicine, Jinan University, Guangzhou 510632, China
Department of Systems Biomedical Sciences, School of Medicine, Jinan University, Guangzhou 510632, China
Guangdong-Hong Kong-Macau Great Bay Area Geroscience Joint Laboratory, School of Medicine, Jinan University, Guangzhou 510632, China
Johns Hopkins Center on Aging and Immune Remodeling, Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, MD 21205 , USA
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Abstract

T cell development and remodeling during aging are crucial for immune health in late life and human healthspan. In this review, we delve into the mechanisms underlying these processes, with a focus on thymus development and involution, and their implications in immune function for older adults. We examine T cell subset development, including conventional naïve and regulatory T cells, effector and memory subsets, and unique subsets like γδ T cells, mucosal-associated invariant T (MAIT) cells, and natural killer T (NKT) cells. Our insights highlight the importance of enhancing immune function in older individuals and suggest potential strategies for overcoming the obstacles in studying T cell development and aging.

Keywords

agingT cell developmentremodelinghumanlifespan

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Aging Research
Volume 2 Issue 1,
March 2024
Article number: 9340021
DOI: 10.26599/AGR.2024.9340021

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Cite this article:
Mao L, Feng Q, Luo OJ, et al. Human T cell development and aging: Remodeling throughout the lifespan. Aging Research, 2024, 2(1): 9340021. https://doi.org/10.26599/AGR.2024.9340021

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Received: 22 January 2024
Revised: 27 February 2024
Accepted: 27 February 2024
Published: 29 March 2024
© The Author(s) 2024. Aging Research published by Tsinghua University Press.

The articles published in this open access journal are distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.