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Review | Open Access

The interaction between microglial dysfunction and mitochondrial impairment in Alzheimer’s disease

Qiudan Luo1, Ji Heon Noh2, Jian Sima1( )
Laboratory of Aging Neuroscience and Neuropharmacology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China
Department of Biochemistry, Chungnam National University, Daejeon 34134, Korea
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Abstract

Alzheimer's disease (AD), a prevalent form of dementia in the elderly, is characterized by marked neurodegeneration and cognitive decline. Central to its pathology are Amyloid-beta plaques, neurofibrillary tangles, and neuroinflammation. This review delves into the pivotal role of microglia, the primary immune cells in the central nervous system, in AD's progression. We highlight recent discoveries revealing how abnormal microglial activity, influenced by mitochondrial dysfunction, contributes to AD development. Special attention is given to the bidirectional relationship between microglia and mitochondria, including the impact of metabolic disturbances and energy dysregulation on microglial function. Further, we explore the mechanisms underlying microglial activation and its consequences on neuronal health, including the interplay between inflammatory pathways and mitochondrial dynamics. Our comprehensive analysis underscores the significance of mitochondrial homeostasis in microglial functionality and its implications for AD progression, offering insights into potential therapeutic avenues targeting microglial mitochondria in AD.

Keywords

microgliamitochondriaAlzheimer's disease (AD)neuroinflammation

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Aging Research
Volume 1 Issue 2,
December 2023
Article number: 9340020
DOI: 10.26599/AGR.2023.9340020
Cite this article:
Luo Q, Noh JH, Sima J. The interaction between microglial dysfunction and mitochondrial impairment in Alzheimer’s disease. Aging Research, 2023, 1(2): 9340020. https://doi.org/10.26599/AGR.2023.9340020

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Received: 21 November 2023
Revised: 13 December 2023
Accepted: 22 December 2023
Published: 16 January 2024
© The Author(s) 2024. Aging Research published by Tsinghua University Press.

The articles published in this open access journal are distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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