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Journal of Neurorestoratology 2016, 4(1): 23-33 https://doi.org/10.2147/JN.S98835
Original Research | Open Access | Issue | Published: 04 April 2016

Transplantation of human umbilical cord blood-derived mononuclear cells induces recovery of motor dysfunction in a rat model of Parkinson’s disease

Show Author's Information Chao Chen1,*,  Jing Duan1,*,  Aifang Shen2,*,  Wei Wang1,  Hao Song1,  Yanming Liu1,  Xianjie Lu1,  Xiaobing Wang2,  Zhiqing You1,  Zhongchao Han3,4,  Fabin Han1( )
Center for Stem Cells and Regenerative Medicine, The Liaocheng People’s Hospital, Affiliated Liaocheng Hospital, Taishan Medical University, Shandong, People’s Republic of China
Department of Gynecology and Obstetrics, The Liaocheng People’s Hospital, Affiliated Liaocheng Hospital, Taishan Medical University, Shandong, People’s Republic of China
The State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences, Peking Union of Medical College, Tianjin, People’s Republic of China
National Engineering Research Center of Cell Products, AmCellGene Co. Ltd., TEDA, Tianjin, People’s Republic of China

* These authors contributed equally to this work

Keywords:
Parkinson’s disease, transplantation, differentiation, hUCB-MNCs, dopamine neurons
Cite this article:
Chen C, Duan J, Shen A, et al. Transplantation of human umbilical cord blood-derived mononuclear cells induces recovery of motor dysfunction in a rat model of Parkinson’s disease. Journal of Neurorestoratology, 2016, 4(1): 23-33. https://doi.org/10.2147/JN.S98835
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Abstract Full text About this article

Human umbilical cord blood-derived mononuclear cells (hUCB-MNCs) were reported to have neurorestorative capacity for neurological disorders such as stroke and traumatic brain injury. This study was performed to explore if hUCB-MNC transplantation plays any therapeutic effects for Parkinson’s disease (PD) in a 6-OHDA-lesioned rat model of PD. hUCB-MNCs were isolated from umbilical cord blood and administered to the striatum of the 6-OHDA-lesioned rats. The apomorphine-induced locomotive turning-overs were measured to evaluate the improvement of motor dysfunctions of the rats after administration of hUCB-MNCs. We observed that transplanted hUCB-MNCs significantly improve the motor deficits of the PD rats and that grafted hUCB-MNCs integrated to the host brains and differentiated to neurons and dopamine neurons in vivo after 16 weeks of transplantation. Our study provided evidence that transplanted hUCB-MNCs play therapeutic effects in a rat PD model by differentiating to neurons and dopamine neurons.


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About this article

Transplantation of human umbilical cord blood-derived mononuclear cells induces recovery of motor dysfunction in a rat model of Parkinson’s disease

Show Author's information Chao Chen1,*, Jing Duan1,*, Aifang Shen2,*, Wei Wang1, Hao Song1, Yanming Liu1, Xianjie Lu1, Xiaobing Wang2, Zhiqing You1, Zhongchao Han3,4, Fabin Han1( )
Center for Stem Cells and Regenerative Medicine, The Liaocheng People’s Hospital, Affiliated Liaocheng Hospital, Taishan Medical University, Shandong, People’s Republic of China
Department of Gynecology and Obstetrics, The Liaocheng People’s Hospital, Affiliated Liaocheng Hospital, Taishan Medical University, Shandong, People’s Republic of China
The State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences, Peking Union of Medical College, Tianjin, People’s Republic of China
National Engineering Research Center of Cell Products, AmCellGene Co. Ltd., TEDA, Tianjin, People’s Republic of China

* These authors contributed equally to this work

Abstract

Human umbilical cord blood-derived mononuclear cells (hUCB-MNCs) were reported to have neurorestorative capacity for neurological disorders such as stroke and traumatic brain injury. This study was performed to explore if hUCB-MNC transplantation plays any therapeutic effects for Parkinson’s disease (PD) in a 6-OHDA-lesioned rat model of PD. hUCB-MNCs were isolated from umbilical cord blood and administered to the striatum of the 6-OHDA-lesioned rats. The apomorphine-induced locomotive turning-overs were measured to evaluate the improvement of motor dysfunctions of the rats after administration of hUCB-MNCs. We observed that transplanted hUCB-MNCs significantly improve the motor deficits of the PD rats and that grafted hUCB-MNCs integrated to the host brains and differentiated to neurons and dopamine neurons in vivo after 16 weeks of transplantation. Our study provided evidence that transplanted hUCB-MNCs play therapeutic effects in a rat PD model by differentiating to neurons and dopamine neurons.

Keywords: Parkinson’s disease, transplantation, differentiation, hUCB-MNCs, dopamine neurons

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Published: 04 April 2016
Issue date: December 2016

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© 2016 The Author(s).

Acknowledgements

The authors thank all the participants in the study. Funding was provided through the Science and Technology Department of Shandong Province, Shandong, People’s Republic of China (2012GSF11808).

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