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Journal of Neurorestoratology 2015, 3(1): 115-120 https://doi.org/10.2147/JN.S92869
Case Report | Open Access | Issue | Published: 15 October 2015

Treatment with adipose stem cells in a patient with moderate Alzheimer’s disease: case report

Show Author's Information Magda Tsolaki1,2,  Stelios Zygouris1,3,  Vassilis Tsoutsikas2,  Doxakis Anestakis2,4,5( ),  George Koliakos6,7
Third Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
Greek Association of Alzheimer’s Disease and Related Disorders, Thessaloniki, Greece
CND+,
Laboratory of Forensic Medicine and Toxicology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
Laboratory of General Biology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
Biohellenika Stem Cells Bank, Thessaloniki, Greece
Department of Biological Chemistry, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
Keywords:
dementia, Alzheimer’s disease, stem cells, case report
Cite this article:
Tsolaki M, Zygouris S, Tsoutsikas V, et al. Treatment with adipose stem cells in a patient with moderate Alzheimer’s disease: case report. Journal of Neurorestoratology, 2015, 3(1): 115-120. https://doi.org/10.2147/JN.S92869
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Abstract Full text About this article
Objective:

This article presents the case of a female patient with Alzheimer’s disease (AD). The patient was treated with cholinesterase inhibitors and also with intravenous administration of autologous adipose stem cells.

Methods:

The patient was assessed with a neuropsychological battery including measures of general cognition, functional problems, neuropsychiatric issues, memory (verbal, visual and episodic), verbal learning and visuospatial abilities. Magnetic resonance imaging (MRI) scans were conducted before and after the treatment with stem cells.

Results:

A transient and mild improvement of scores in measures of general cognition and neuropsychiatric issues was evident. A rapid deterioration followed the initial improvement. The first MRI scan showed ischemic areas in periventricular white matter of both hemispheres, as well as in both temporal and parietal lobes. The second MRI scan revealed the same picture with no significant changes.

Conclusion:

This case report indicates that the administration of stem cells is feasible in a clinical setting however its effectiveness in the treatment of AD is uncertain. The improvement of the patient’s condition highlights the potential therapeutic action of stem cells, however the rapid deterioration poses questions concerning limited effectiveness or possible side effects of stem cell administration. Further research is needed in order to clarify the method’s effectiveness.


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Abstract
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About this article

Treatment with adipose stem cells in a patient with moderate Alzheimer’s disease: case report

Show Author's information Magda Tsolaki1,2, Stelios Zygouris1,3, Vassilis Tsoutsikas2, Doxakis Anestakis2,4,5( ), George Koliakos6,7
Third Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
Greek Association of Alzheimer’s Disease and Related Disorders, Thessaloniki, Greece
CND+,
Laboratory of Forensic Medicine and Toxicology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
Laboratory of General Biology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
Biohellenika Stem Cells Bank, Thessaloniki, Greece
Department of Biological Chemistry, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

Abstract

Objective:

This article presents the case of a female patient with Alzheimer’s disease (AD). The patient was treated with cholinesterase inhibitors and also with intravenous administration of autologous adipose stem cells.

Methods:

The patient was assessed with a neuropsychological battery including measures of general cognition, functional problems, neuropsychiatric issues, memory (verbal, visual and episodic), verbal learning and visuospatial abilities. Magnetic resonance imaging (MRI) scans were conducted before and after the treatment with stem cells.

Results:

A transient and mild improvement of scores in measures of general cognition and neuropsychiatric issues was evident. A rapid deterioration followed the initial improvement. The first MRI scan showed ischemic areas in periventricular white matter of both hemispheres, as well as in both temporal and parietal lobes. The second MRI scan revealed the same picture with no significant changes.

Conclusion:

This case report indicates that the administration of stem cells is feasible in a clinical setting however its effectiveness in the treatment of AD is uncertain. The improvement of the patient’s condition highlights the potential therapeutic action of stem cells, however the rapid deterioration poses questions concerning limited effectiveness or possible side effects of stem cell administration. Further research is needed in order to clarify the method’s effectiveness.

Keywords: dementia, Alzheimer’s disease, stem cells, case report

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Published: 15 October 2015
Issue date: December 2015

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© 2015 The Author(s).

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© 2015 Tsolaki et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

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