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Methodology | Open Access

Proliferation and differentiation of human fetal brain neural stem cells in vitro

Erica L McGrath1, Junling Gao1, Ping Wu1,2( )
Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX, USA
Beijing Institute for Brain Disorders, Capital Medical University, Beijing, People’s Republic of China
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Abstract

Primary human fetal brain neural stem cells (hNSCs) are a unique non-genetically modified model system to study molecular mechanisms underlying human neural development, to model human diseases, and to screen drugs or validate new treatments. They may also be used for cell transplantation to treat various neurological diseases. This protocol details our methods that can be used to expand hNSCs in culture as well as how to differentiate them into various neuronal lineages and astrocytes.

Keywords

neural stem cellproliferationdifferentiationneuronastrocyte

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Journal of Neurorestoratology
Volume 6 Issue 1,
December 2018
Pages 19-27
DOI: 10.2147/JN.S148794

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Cite this article:
McGrath EL, Gao J, Wu P. Proliferation and differentiation of human fetal brain neural stem cells in vitro. Journal of Neurorestoratology, 2018, 6(1): 19-27. https://doi.org/10.2147/JN.S148794

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Published: 26 June 2018
© The authors 2018.

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