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Journal of Neurorestoratology 2017, 5(1): 31-38 https://doi.org/10.2147/JN.S115696
Review | Open Access | Issue | Published: 13 February 2017

Anti-inflammatory effect of stem cells against spinal cord injury via regulating macrophage polarization

Show Author's Information Zhijian Cheng,  Xijing He( )
Department of Orthopedics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China
Keywords:
polarization, spinal cord injury, stem cells, macrophages
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Cheng Z, He X. Anti-inflammatory effect of stem cells against spinal cord injury via regulating macrophage polarization. Journal of Neurorestoratology, 2017, 5(1): 31-38. https://doi.org/10.2147/JN.S115696
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Abstract Full text About this article

Spinal cord injury (SCI) is a traumatic event that involves not just an acute physical injury but also inflammation-driven secondary injury. Macrophages play a very important role in secondary injury. The effects of macrophages on tissue damage and repair after SCI are related to macrophage polarization. Stem cell transplantation has been studied as a promising treatment for SCI. Recently, increasing evidence shows that stem cells, including mesenchymal stem, neural stem/progenitor, and embryonic stem cells, have an anti-inflammatory capacity and promote functional recovery after SCI by inducing macrophages M1/M2 phenotype transformation. In this review, we will discuss the role of stem cells on macrophage polarization and its role in stem cell-based therapies for SCI.


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About this article

Anti-inflammatory effect of stem cells against spinal cord injury via regulating macrophage polarization

Show Author's information Zhijian Cheng, Xijing He( )
Department of Orthopedics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China

Abstract

Spinal cord injury (SCI) is a traumatic event that involves not just an acute physical injury but also inflammation-driven secondary injury. Macrophages play a very important role in secondary injury. The effects of macrophages on tissue damage and repair after SCI are related to macrophage polarization. Stem cell transplantation has been studied as a promising treatment for SCI. Recently, increasing evidence shows that stem cells, including mesenchymal stem, neural stem/progenitor, and embryonic stem cells, have an anti-inflammatory capacity and promote functional recovery after SCI by inducing macrophages M1/M2 phenotype transformation. In this review, we will discuss the role of stem cells on macrophage polarization and its role in stem cell-based therapies for SCI.

Keywords: polarization, spinal cord injury, stem cells, macrophages

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Published: 13 February 2017
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