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Review | Open Access

Anti-inflammatory effect of stem cells against spinal cord injury via regulating macrophage polarization

Zhijian Cheng, Xijing He( )
Department of Orthopedics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China
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Abstract

Spinal cord injury (SCI) is a traumatic event that involves not just an acute physical injury but also inflammation-driven secondary injury. Macrophages play a very important role in secondary injury. The effects of macrophages on tissue damage and repair after SCI are related to macrophage polarization. Stem cell transplantation has been studied as a promising treatment for SCI. Recently, increasing evidence shows that stem cells, including mesenchymal stem, neural stem/progenitor, and embryonic stem cells, have an anti-inflammatory capacity and promote functional recovery after SCI by inducing macrophages M1/M2 phenotype transformation. In this review, we will discuss the role of stem cells on macrophage polarization and its role in stem cell-based therapies for SCI.

Keywords

stem cellsmacrophagesspinal cord injurypolarization

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Journal of Neurorestoratology
Volume 5 Issue 1,
December 2017
Pages 31-38
DOI: 10.2147/JN.S115696

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Cheng Z, He X. Anti-inflammatory effect of stem cells against spinal cord injury via regulating macrophage polarization. Journal of Neurorestoratology, 2017, 5(1): 31-38. https://doi.org/10.2147/JN.S115696

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Published: 13 February 2017
© 2017 The Author(s).

© 2017 Cheng and He. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).