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Letter | Open Access

Unveiling molecular incomplete response (mIR) via ultra-deep NGS: a novel concept contrasting pathologic complete response (pCR) in occult lymph node micrometastases of non-small cell lung cancer

Meng Lu1,2Ran Zhang1Haidi Xu1Bingsheng Sun2Peng Chen3Xuan Gao4Meiming Zhong4Jian You1,2 ( )
Department of Thoracic Oncology, Tianjin Cancer Hospital Airport Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
Department of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
Department of Pulmonary Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
Beijing Gene+, Inc., Beijing 102200, China
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Cancer Biology & Medicine
Pages 1198-1203

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Cite this article:
Lu M, Zhang R, Xu H, et al. Unveiling molecular incomplete response (mIR) via ultra-deep NGS: a novel concept contrasting pathologic complete response (pCR) in occult lymph node micrometastases of non-small cell lung cancer. Cancer Biology & Medicine, 2026, 23(8): 1198-1203. https://doi.org/10.20892/j.issn.2095-3941.2026.0171

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Received: 26 February 2026
Accepted: 09 April 2026
Published: 12 June 2026
©2026 The Authors.

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