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Letter | Open Access

A foundation model-enhanced CT radiomics signature for the noninvasive assessment of tertiary lymphoid structures and prediction of therapy benefit in gastric cancer

Xianchun Gao1,*, Zhe Li2,*, Jun Yu1,*, Jiangpeng Wei3,*, Didi Wen4,*, Ning Han1, Linbin Lu1, Yongxi Song5, Qiong Xiao5, Guangtao Wu5, Kun Feng5, Shibo Wang1, Zhongyang Zhang1, Dai Zhang1, Ling Chen6, Zengshan Li6, Minwen Zheng4( ), Yong Xia2( ), Yongzhan Nie1 ( )
State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
School of Computer Science and Engineering, Northwestern Polytechnical University, Xi’an 710068, China
Department of Digestive Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors (China Medical University), Ministry of Education, Shenyang 110100, China
State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi’an 710032, China

*These authors contributed equally to this work.

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Cancer Biology & Medicine
Volume 23 Issue 9,
September 2026
Pages 1346-1351
DOI: 10.20892/j.issn.2095-3941.2026.0076

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Gao X, Li Z, Yu J, et al. A foundation model-enhanced CT radiomics signature for the noninvasive assessment of tertiary lymphoid structures and prediction of therapy benefit in gastric cancer. Cancer Biology & Medicine, 2026, 23(9): 1346-1351. https://doi.org/10.20892/j.issn.2095-3941.2026.0076

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Received: 26 January 2026
Accepted: 06 March 2026
Published: 16 April 2026
©2026 The Authors.

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